LOCUS       NM_015302               4324 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens HAUS augmin like complex subunit 5 (HAUS5), mRNA.
ACCESSION   NM_015302 XM_049237 XM_932173 XM_932194 XM_942304 XM_945890
            XM_945898
VERSION     NM_015302.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4324)
  AUTHORS   Zhang,W., Yang,C., Hu,Y., Yi,K., Xiao,W., Xu,X. and Chen,Z.
  TITLE     Comprehensive analysis of the correlation of the pan-cancer gene
            HAUS5 with prognosis and immune infiltration in liver cancer
  JOURNAL   Sci Rep 13 (1), 2409 (2023)
   PUBMED   36765148
  REMARK    GeneRIF: Comprehensive analysis of the correlation of the
            pan-cancer gene HAUS5 with prognosis and immune infiltration in
            liver cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4324)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4324)
  AUTHORS   Luo,J., Yang,B., Xin,G., Sun,M., Zhang,B., Guo,X., Jiang,Q. and
            Zhang,C.
  TITLE     The microtubule-associated protein EML3 regulates mitotic spindle
            assembly by recruiting the Augmin complex to spindle microtubules
  JOURNAL   J Biol Chem 294 (14), 5643-5656 (2019)
   PUBMED   30723163
REFERENCE   4  (bases 1 to 4324)
  AUTHORS   Cunha-Ferreira,I., Chazeau,A., Buijs,R.R., Stucchi,R., Will,L.,
            Pan,X., Adolfs,Y., van der Meer,C., Wolthuis,J.C., Kahn,O.I.,
            Schatzle,P., Altelaar,M., Pasterkamp,R.J., Kapitein,L.C. and
            Hoogenraad,C.C.
  TITLE     The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule
            Organization during Neuronal Development
  JOURNAL   Cell Rep 24 (4), 791-800 (2018)
   PUBMED   30044976
REFERENCE   5  (bases 1 to 4324)
  AUTHORS   Ding,Y., Herman,J.A., Toledo,C.M., Lang,J.M., Corrin,P.,
            Girard,E.J., Basom,R., Delrow,J.J., Olson,J.M. and Paddison,P.J.
  TITLE     ZNF131 suppresses centrosome fragmentation in glioblastoma
            stem-like cells through regulation of HAUS5
  JOURNAL   Oncotarget 8 (30), 48545-48562 (2017)
   PUBMED   28596487
  REMARK    GeneRIF: Our results suggest that GSCs differentially rely on
            ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS
            complex activity to maintain the integrity of centrosome function
            and viability.
REFERENCE   6  (bases 1 to 4324)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 4324)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   8  (bases 1 to 4324)
  AUTHORS   Lawo,S., Bashkurov,M., Mullin,M., Ferreria,M.G., Kittler,R.,
            Habermann,B., Tagliaferro,A., Poser,I., Hutchins,J.R., Hegemann,B.,
            Pinchev,D., Buchholz,F., Peters,J.M., Hyman,A.A., Gingras,A.C. and
            Pelletier,L.
  TITLE     HAUS, the 8-subunit human Augmin complex, regulates centrosome and
            spindle integrity
  JOURNAL   Curr Biol 19 (10), 816-826 (2009)
   PUBMED   19427217
REFERENCE   9  (bases 1 to 4324)
  AUTHORS   Uehara,R., Nozawa,R.S., Tomioka,A., Petry,S., Vale,R.D., Obuse,C.
            and Goshima,G.
  TITLE     The augmin complex plays a critical role in spindle microtubule
            generation for mitotic progression and cytokinesis in human cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6998-7003 (2009)
   PUBMED   19369198
REFERENCE   10 (bases 1 to 4324)
  AUTHORS   Goshima,G., Mayer,M., Zhang,N., Stuurman,N. and Vale,R.D.
  TITLE     Augmin: a protein complex required for centrosome-independent
            microtubule generation within the spindle
  JOURNAL   J Cell Biol 181 (3), 421-429 (2008)
   PUBMED   18443220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002115.1, BC064390.1 and AB020648.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015302.1.
            
            Summary: HAUS5 is 1 of 8 subunits of the 390-kD human augmin
            complex, or HAUS complex. The augmin complex was first identified
            in Drosophila, and its name comes from the Latin verb 'augmentare,'
            meaning 'to increase.' The augmin complex is a microtubule-binding
            complex involved in microtubule generation within the mitotic
            spindle and is vital to mitotic spindle assembly (Goshima et al.,
            2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed
            19369198]).[supplied by OMIM, Jun 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.78718.1, AB020648.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000203166.10/ ENSP00000439056.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC002115.1         34784-34792
            10-36               BC064390.1         1-27
            37-3732             AB020648.1         1-3696
            3733-4318           AB020648.1         3698-4283
            4319-4324           AC002115.1         47399-47404
FEATURES             Location/Qualifiers
     source          1..4324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4324
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /note="HAUS augmin like complex subunit 5"
                     /db_xref="GeneID:23354"
                     /db_xref="HGNC:HGNC:29130"
                     /db_xref="MIM:613432"
     exon            1..158
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1962
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /codon_start=1
                     /product="HAUS augmin-like complex subunit 5"
                     /protein_id="NP_056117.1"
                     /db_xref="CCDS:CCDS42550.1"
                     /db_xref="GeneID:23354"
                     /db_xref="HGNC:HGNC:29130"
                     /db_xref="MIM:613432"
                     /translation="MELAQEARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWA
                     YILQHVHSQRTVKKIRGNLLWYGHQDSPQVRRKLELEAAVTRLRAEIQELDQSLELME
                     RDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQDM
                     ERKAKVDVTFGSLTSAALGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPHDD
                     HFGTSYQQWLSSVETLLTNHPPGHVLAALEHLAAEREAEIRSLCSGDGLGDTEISRPQ
                     APDQSDSSQTLPSMVHLIQEGWRTVGVLVSQRSTLLKERQVLTQRLQGLVEEVERRVL
                     GSSERQVLILGLRRCCLWTELKALHDQSQELQDAAGHRQLLLRELQAKQQRILHWRQL
                     VEETQEQVRLLIKGNSASKTRLCRSPGEVLALVQRKVVPTFEAVAPQSRELLRCLEEE
                     VRHLPHILLGTLLRHRPGELKPLPTVLPSIHQLHPASPRGSSFIALSHKLGLPPGKAS
                     ELLLPAAASLRQDLLLLQDQRSLWCWDLLHMKTSLPPGLPTQELLQIQASQEKQQKEN
                     LGQALKRLEKLLKQALERIPELQGIVGDWWEQPGQAALSEELCQGLSLPQWRLRWVQA
                     QGALQKLCS"
     exon            159..221
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            222..254
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            255..279
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            280..385
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            386..545
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            546..615
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            616..698
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            699..756
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            757..881
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            882..945
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1076
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1239
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1320
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1466
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1578
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1711
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1844
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..4324
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2556..2561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /note="hexamer: ATTAAA"
     polyA_site      2579
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /note="major polyA site"
     regulatory      4241..4246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /note="hexamer: TATAAA"
     polyA_site      4261
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
                     /note="hexamer: AATAAA"
     polyA_site      4324
                     /gene="HAUS5"
                     /gene_synonym="dgt5; KIAA0841"
ORIGIN      
        1 agaggcgggc gccacacttg aagaggctga gggaggcggt gtcgccgccg cggcgctgtc
       61 atggagctag cgcaggaagc gcgggaactg ggttgctggg cggtcgaaga gatgggggtg
      121 cccgtggcgg cccgggcccc ggaatcgacg ctgcgcaggc tgtgtctggg ccagggggct
      181 gacatctggg cctacatctt gcagcatgtg cacagtcaga ggactgtcaa gaagatccgg
      241 ggaaacctac tctggtatgg ccaccaggac agtccacagg tccgtcggaa gttagagctg
      301 gaagctgctg tgacccgcct gcgggcagaa atccaggaac tcgaccagag cctggagctg
      361 atggagcgag acactgaggc tcaggacacg gccatggagc aggcacgtca gcacactcaa
      421 gacacccagc gtcgagctct cctcctccgg gcccaagctg gggccatgcg aagacagcag
      481 catacgctcc gagatcccat gcagcggctg cagaatcaac tgaggcgcct gcaggacatg
      541 gagaggaaag ccaaagtaga tgtgaccttt ggatccctca cgtcggcagc tctgggcctg
      601 gagcccgtgg tcctgcgtga tgtccgaaca gcctgcaccc tccgggccca gttcctgcag
      661 aacctcctgc ttccccaggc caagaggggc agcctcccaa cccctcatga tgaccacttt
      721 ggcacttcgt accagcagtg gctgagctca gtggagacgc tgctgacaaa ccacccccca
      781 ggccacgtcc tggctgcctt ggagcacctg gctgcagagc gggaggcaga gattcggtcc
      841 ctgtgcagtg gggatgggct tggcgacaca gagatatcca gaccccaggc cccggaccag
      901 tcagactcca gccagaccct gccgtccatg gttcatctca tccaggaggg ctggcggact
      961 gtgggtgtgc tggtctccca gcggagcacc ctcctgaagg agcggcaagt cttgacccag
     1021 cgcctccagg gcctggtgga ggaggtggag agacgcgtcc tgggatccag tgagaggcag
     1081 gtgctgatac tggggcttcg gcgctgttgc ctgtggacgg agctcaaggc cctgcacgat
     1141 cagagccagg agctgcagga tgcagctggg catcggcagc tcctgctgag ggagctacag
     1201 gccaaacagc agcggatcct gcactggcgc cagctggtgg aggagaccca ggaacaggtc
     1261 cgcctgctca tcaagggaaa ctcggccagc aagacccgcc tgtgccggag cccgggggag
     1321 gtgctagctc tggtccagcg aaaggtggtc cctacatttg aggcagtggc accacagagc
     1381 cgggagctgc tgcgctgtct ggaggaggaa gtccggcatt tgccccacat tctgttgggc
     1441 acgctgctgc ggcacaggcc gggagagttg aagcccctgc ccacggtcct cccatccatc
     1501 caccagctgc accccgcgtc cccaaggggc tccagcttca tagcgctgag ccacaagctg
     1561 gggctgcctc cagggaaggc ctcggagctg ctcctgccgg cggctgcctc tcttcgccag
     1621 gaccttctgc tcctgcagga ccagcggagc ctctggtgct gggatctact ccacatgaag
     1681 accagcctgc cgccaggcct tcccacccag gagctgctgc agatccaggc atcccaggaa
     1741 aaacagcaga aagagaacct ggggcaggct ctgaagaggc tggagaagct actgaaacag
     1801 gcactggagc gaatccctga gctgcagggg atcgtggggg actggtggga gcagccaggc
     1861 caggccgccc tctctgagga gctctgccag ggcctgtccc tgccccagtg gcggctgcgc
     1921 tgggttcagg cccagggggc cctgcagaag ctgtgcagct gaagagaggg ttcaaacgga
     1981 agccgagaac ttgacactgt tcaccccaac acctcacctc ccccaggaca tttggaagaa
     2041 agcagcgcca ggattcctcg gcagtcgtcc ccacccgcac ctgcagtccc ctcatgtgct
     2101 gttctgctgc cccactcagc tcctggaccc tgtcctttca tcccgctaaa gcacccccta
     2161 aaaccccttc atcactttca ttctcagcaa aaagtaattg agcacctcct ctaggcgctg
     2221 gggagtccac actgaacaaa agaaacagaa aaccctgtct tccagcagtt gagttctagg
     2281 gcagggagac agagtttaca agataaggaa aatatatatg tagtatgctg caagttaact
     2341 gctgtgtggg aaatccagca gggggtggga tgtgtgattt gaattgaggg ccacactgcc
     2401 caggtcgtgc tccgtcaagg ggtgagcagg agcaacaggg gtggctgagt aagggcttgc
     2461 agctggaggc aacagcacat gcaaaggccc tgagccagga tgtgctgcaa taagggccac
     2521 tgagggggac agtgtaggtt gggggtgagg aatgtattaa aagatgagat tgccttctag
     2581 tttgtatagt ttcttttttt acatgtaaat cagccatttg gaatttatcc tagcacatgg
     2641 atccaatttt gtcttatttt acatatatcc tagtagcact tactgaaatt cccagtcaga
     2701 gtggcagttg cctctgaggg aaggtgggtg gcagggatca actgaggagg agacacagaa
     2761 atgtcctagc tgatgggaat gtgctgtgtc aagagcagcg gcggtgacgc aggtgtagag
     2821 atttgtcaga gctcatgtag ttgtagtctt aaggcctgtg catttcactg cgtgggttac
     2881 tcaatttata aagcaaagcc cttacacttt tgagatgcca cctttttatg cactaaattt
     2941 ccatgtttaa ttgggttata tctggcttct ctccagacct gctttgtatt taactctcca
     3001 tgtgtcattc ctacagtagc ttaatagaaa ggcttgtgac acattgtcat atctgttctt
     3061 gttttctttt gttttttttt tttttttttt tgagatgcag tctcattctg ttgcccaagt
     3121 tggagtgcag tggcatgatc tcagctcact gcaacctccg cctcccaggt tcaagccatt
     3181 ctcatgcctc agcttcccca gtagctagga ttacaggtac gcaccaccac gcccagctca
     3241 tttttgtact tttagtaggg acggggtttc atcatgttgg ccagactggt ctcgaactcc
     3301 tgacctcaag tgatctgcct gcctcggcct cccaaagtgc tgggattaca ggcatgagcc
     3361 accgcgcctg accacattgc catatctgaa atggctggat tctcttaggt gcttttcttt
     3421 ttctttcttt ctttcttttt ttgagacaga atctggctgt ttcccaggct gaagtgcagt
     3481 ggcatgaact cagctcactg caacctctgc ctcctggatt caaacaattc tcatgtctca
     3541 gcctcctgaa tagctgggat tacaggcacc caccaccata tctggctaat atttgtattt
     3601 tttgtagagt cggagcttta ccatgttggt caggctgctc tccaactcct ggcctcaagt
     3661 gattctatcg cctctgcctc ccaaatcttc acctgctggg attagtttcc cctgtctcag
     3721 taaatttttt ttcccaaact aagtgaacat tagatttaat ttggctggcc ccagaagaaa
     3781 aacatgcaca gatggtagtt ttactggtgt tgcagtaagt tttcaaattt ggaagtttgg
     3841 cagctttatg atcttgaacc ttgctgtcca tctctcacac aactcctctc ttggcctcca
     3901 gagtcccttt actctcccag ctttcctcct gcccctggct gctgtttccc agcctttcca
     3961 cattggcttt cccatgtagt ccttagtgtg tctgctcctc ctctctctcc tcatcacagt
     4021 tcccagcccc caccttcaac tgaactcaac aaaatcttca acttcataca gtagtcacat
     4081 tgttagtaat aacactggca tttttatttt gataaaatag accgtttaaa tttttgagat
     4141 tctaccttat attttttgaa ttatatacta aagcaaataa gtagtgatgt aatgtcattg
     4201 gggaccaaga tttttagtgt aaatgaaaaa agataacaaa tataaactca agtaaacacc
     4261 ctgtagtctt tcacatgaat tggaaatatc agaataaagt catgattttt ctctttctaa
     4321 aaaa
//
