LOCUS       NM_001303143            5879 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens HAUS augmin like complex subunit 3 (HAUS3), transcript
            variant 1, mRNA.
ACCESSION   NM_001303143
VERSION     NM_001303143.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5879)
  AUTHORS   Yu,X., Zhao,P., Luo,Q., Wu,X., Wang,Y., Nan,Y., Liu,S., Gao,W.,
            Li,B., Liu,Z. and Cui,Z.
  TITLE     RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote
            ROS-mediated NF-kappaB activation and ovarian cancer progression
  JOURNAL   Oncogene 43 (6), 420-433 (2024)
   PUBMED   38092960
  REMARK    GeneRIF: RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to
            promote ROS-mediated NF-kappaB activation and ovarian cancer
            progression.
REFERENCE   2  (bases 1 to 5879)
  AUTHORS   Zhang,Y., Chen,H., Yuan,R., Wang,Y., Zhang,D., Zeng,Q., Jiang,W.,
            Zhang,R., Chen,T., Chai,C. and Guo,B.
  TITLE     PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression
            via activating NF-kappaB signaling pathway
  JOURNAL   Mol Carcinog 62 (7), 1009-1024 (2023)
   PUBMED   37042573
  REMARK    GeneRIF: PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer
            progression via activating NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 5879)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5879)
  AUTHORS   Luo,J., Yang,B., Xin,G., Sun,M., Zhang,B., Guo,X., Jiang,Q. and
            Zhang,C.
  TITLE     The microtubule-associated protein EML3 regulates mitotic spindle
            assembly by recruiting the Augmin complex to spindle microtubules
  JOURNAL   J Biol Chem 294 (14), 5643-5656 (2019)
   PUBMED   30723163
REFERENCE   6  (bases 1 to 5879)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   7  (bases 1 to 5879)
  AUTHORS   Shah,S.P., Morin,R.D., Khattra,J., Prentice,L., Pugh,T.,
            Burleigh,A., Delaney,A., Gelmon,K., Guliany,R., Senz,J., Steidl,C.,
            Holt,R.A., Jones,S., Sun,M., Leung,G., Moore,R., Severson,T.,
            Taylor,G.A., Teschendorff,A.E., Tse,K., Turashvili,G., Varhol,R.,
            Warren,R.L., Watson,P., Zhao,Y., Caldas,C., Huntsman,D., Hirst,M.,
            Marra,M.A. and Aparicio,S.
  TITLE     Mutational evolution in a lobular breast tumour profiled at single
            nucleotide resolution
  JOURNAL   Nature 461 (7265), 809-813 (2009)
   PUBMED   19812674
REFERENCE   8  (bases 1 to 5879)
  AUTHORS   Lawo,S., Bashkurov,M., Mullin,M., Ferreria,M.G., Kittler,R.,
            Habermann,B., Tagliaferro,A., Poser,I., Hutchins,J.R., Hegemann,B.,
            Pinchev,D., Buchholz,F., Peters,J.M., Hyman,A.A., Gingras,A.C. and
            Pelletier,L.
  TITLE     HAUS, the 8-subunit human Augmin complex, regulates centrosome and
            spindle integrity
  JOURNAL   Curr Biol 19 (10), 816-826 (2009)
   PUBMED   19427217
REFERENCE   9  (bases 1 to 5879)
  AUTHORS   Uehara,R., Nozawa,R.S., Tomioka,A., Petry,S., Vale,R.D., Obuse,C.
            and Goshima,G.
  TITLE     The augmin complex plays a critical role in spindle microtubule
            generation for mitotic progression and cytokinesis in human cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6998-7003 (2009)
   PUBMED   19369198
REFERENCE   10 (bases 1 to 5879)
  AUTHORS   Goshima,G., Mayer,M., Zhang,N., Stuurman,N. and Vale,R.D.
  TITLE     Augmin: a protein complex required for centrosome-independent
            microtubule generation within the spindle
  JOURNAL   J Cell Biol 181 (3), 421-429 (2008)
   PUBMED   18443220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003648.2, BF508642.1 and
            AL158068.18.
            
            On Jun 2, 2019 this sequence version replaced NM_001303143.1.
            
            Summary: This gene encodes a component of the HAUS augmin-like
            protein complex, which plays a key role in cytokinesis and mitosis.
            Disruption of the encoded protein causes mitotic defects resulting
            from fragmentation of centrosomes and microtubule destabilization.
            This gene shares its 5' exons with some transcripts from
            overlapping GeneID: 353497, which encodes a DNA polymerase.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.118543.1,
                                           SRR1803616.200307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443786.3/ ENSP00000392903.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               BC003648.2         44-572
            530-2387            BC003648.2         574-2431
            2388-2392           BF508642.1         17-21               c
            2393-5879           AL158068.18        118173-121659
FEATURES             Location/Qualifiers
     source          1..5879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5879
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="HAUS augmin like complex subunit 3"
                     /db_xref="GeneID:79441"
                     /db_xref="HGNC:HGNC:28719"
                     /db_xref="MIM:613430"
     exon            1..71
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..342
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1398
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..2301
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /codon_start=1
                     /product="HAUS augmin-like complex subunit 3"
                     /protein_id="NP_001290072.1"
                     /db_xref="CCDS:CCDS33941.1"
                     /db_xref="GeneID:79441"
                     /db_xref="HGNC:HGNC:28719"
                     /db_xref="MIM:613430"
                     /translation="MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFC
                     GNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKL
                     EDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMIT
                     KISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYT
                     KKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQL
                     IHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDR
                     SLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYE
                     IELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHR
                     LYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVD
                     MLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLH
                     QMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED"
     exon            1399..1838
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2067
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..5879
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="major polyA site"
     regulatory      3011..3016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="major polyA site"
     regulatory      5468..5473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="hexamer: AACAAG"
     polyA_site      5490
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
     polyA_site      5538
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
     regulatory      5579..5584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
                     /note="hexamer: AGTAAA"
     polyA_site      5600
                     /gene="HAUS3"
                     /gene_synonym="C4orf15; dgt3; IT1"
ORIGIN      
        1 agtgcgaggc gcgcggggca cggagggcgg tggcggcggg ctcctgcgag aagcaagcgg
       61 aacttcctga gcgtgcttag gtgtcacagc tgggtgaccc tccgaaggaa ggttttgccg
      121 ctggcgcgtc tggtgtatcg cggccttggg gccgcggatc cctggggctt gccgctgcct
      181 ctggggttcg cgcggccctg gcgtcggggc tgcctcagcg ctggctgaag gccggcccga
      241 agcaccctta attgtggccg cgcgcttccc tgctgctcct gctgttctcc gcgtcgcggt
      301 ggtggactct ggaggtggag ccttgcccgg cgagacgttg aggaggaatc attatagatt
      361 ctaaaaatat attttccctt ctctgtggac ttggtataaa acgtagcttt ttttctgctt
      421 ggatttattt tctaaaaatc aacaccgtaa acccatatca gatacaacaa aattggggta
      481 gttaaaacca tgagttgtgg aaatgagttt gtggaaacat taaaaaaaat tggttatccc
      541 aaagctgata atcttaatgg agaagacttt gactggttgt ttgagggcgt tgaagatgaa
      601 tcgtttctga agtggttttg tgggaatgtg aatgaacaga acgtgttgtc tgaaagagaa
      661 ttggaagctt ttagcattct tcagaaatca ggcaagccta ttctagaagg ggcggcattg
      721 gatgaagctc ttaaaacgtg taaaacttct gatttgaaga cacctagact ggatgataaa
      781 gagctggaga aattagagga tgaggttcaa actctactga aattaaagaa cctaaaaatt
      841 cagcgacgta ataaatgtca attgatggct tcagtaacta gccacaaatc tctgaggtta
      901 aatgctaaag aagaagaagc cactaaaaag ctgaagcaga gtcaaggaat tctaaatgca
      961 atgatcacta agatcagtaa tgaacttcag gctcttactg atgaagttac acaattgatg
     1021 atgttcttca gacattctaa tttaggtcaa gggacaaatc cactggtatt tttatcgcaa
     1081 ttttccttgg aaaaatacct aagtcaggaa gagcaaagca cagcagcatt aactttgtat
     1141 accaaaaaac agttctttca gggtatacat gaagtagttg aaagttcaaa tgaagacaat
     1201 tttcaacttt tagatataca gacaccatct atttgtgata atcaagaaat ccttgaggag
     1261 agacgactag agatggctag actgcagctc gcatacattt gtgctcaaca tcagttaatt
     1321 cacttaaaag caagtaattc gagcatgaag tcaagtataa aatgggcaga ggagagtctt
     1381 cacagcctaa ccagcaaggc tgtggacaaa gaaaatttgg atgctaaaat ttctagcttg
     1441 accagtgaga ttatgaaact tgaaaaagag gtcactcaaa taaaagacag aagtttacct
     1501 gctgtggtaa gagagaatgc ccagttattg aatatgccag tggtaaaggg agattttgat
     1561 ctgcagattg ctaaacaaga ttattataca gcaagacaag agttagtttt aaatcaatta
     1621 ataaaacaaa aggcatcatt tgaacttcta cagttatcat atgaaattga attaagaaag
     1681 catcgggaca tatatcgtca acttgaaaat ttggttcaag aacttagtca aagtaacatg
     1741 atgctctaca agcaattaga aatgttaaca gatccatcag tttctcaaca gataaatcca
     1801 aggaatacca ttgatactaa ggattattct actcataggc tttaccaagt tttggaggga
     1861 gagaataaga aaaaagaatt gtttctaact catggaaacc ttgaggaagt ggctgagaaa
     1921 ttgaaacaga atatttcttt agtacaagat cagttggcag tatctgctca agaacattct
     1981 ttctttctgt ccaaacggaa taaggatgtg gacatgcttt gtgatacttt gtatcaagga
     2041 ggaaatcagc ttttgcttag tgatcaggag ttaacagagc agtttcataa agttgaatct
     2101 caactgaata agctaaatca tctcctcact gatattcttg ctgatgtgaa gacaaaaaga
     2161 aaaactttgg caaataataa attacatcaa atggaaagag aattctatgt atatttttta
     2221 aaagatgaag attatctgaa agatattgtg gagaatttag aaactcaatc aaagattaag
     2281 gctgttagtc ttgaagattg aaaattactg aaaactgaat ctttattacg tgtcctcttt
     2341 tatttattag aagactgtgt ataataaaca ctactaaatt tttaaaattt gaggtcaatg
     2401 gaacatttaa tttgatgaat tgaactatta tattaatttg tcttttttct catgtagtac
     2461 attcagaata ccagtgcttt ttatgacttg agcatgtgtt tagtggtact tagtcctggt
     2521 aattttttac ttacagggaa aaagcattat tacataatgc aaatattttt taatatagtt
     2581 atctctctcc tttttagaaa tagaaatttt ctgccgttaa attttttttt gagatagagt
     2641 ctcactctgt ctccaggctg gaatgcagtg gcacgatctt ggctcactgc aacctctgcc
     2701 tcccgggttc aagtgattct cctgcctcag cctcccaagt agctgggact acaggcgcac
     2761 accgccacac ccagctaatt tttttgtatt ttagtagaaa aggggtttca ccatgttggc
     2821 caggatggtc tcaatctctt gacctcttga tcccctctcc cggcctccca aagtgccgga
     2881 attacaggca tgagccacca cgctcagccg ctattaaata ttttaaaatg tgtagaactt
     2941 ctagtcagca tttttaaatc tgtagacctt aatatgtgaa atagccaagt cccctcatgt
     3001 ttgactgtca aataaaattc tgctgctcaa attgtattcc tccataattc cctgctatag
     3061 acctttaggc tgttttaatg tccctacttg taccacagag tattaggact tccttggcct
     3121 gcctgcattc attttagagt ctgaattctg gggactcaaa agtttctaca agacagctga
     3181 gcagtgcttt gactttaatg tgacttacac atcataaatg actttcaaat gaaatttgaa
     3241 tttcaaaatt ctgtaaaagt ggttgctcaa aagatgtatg atactatttt aatcagttta
     3301 agagcaaaaa tgtctaattg tatttaacaa tggtatttgg gcagccagaa aatattttaa
     3361 gcgttgctct aaaataattt gaagtagctc atctgttatt acatcagatg cttcttgagt
     3421 gcccaattta tacatggcct gtggtaaata ccatgtgagc tttgtaggaa tacctttaag
     3481 aatattcctc acctgttcgt aatatggaat gccaatctaa aaactacatg ttttgggtgg
     3541 tctttatgga attttttagc tataaccatc agaaaacagg catacctaga tgacagatga
     3601 accttcttga tttttgaaac ccattgaaca aaaatatttt gccaattatt gtgtttatgt
     3661 tatttaaaat tttatgtaaa ccttaatttt gtagcagtaa attttgttta agattttgct
     3721 atcagctccc tatcacctga gcaacttttt ttttgttgta tatgtttttt tctattctat
     3781 ttcggaatag agaatttact taaaattttt attttctcca aaaatgtgga aaatatgtca
     3841 cctggtttcc tggtttatgg tagcatattc tgtttaaatt agtgtcacat atttagatgt
     3901 gtggccagac gcttgattta ttagttaatt tttgagacag agtctaactg tgtcactcag
     3961 gctggagttc agtggaatga tctcggctca ctgcaacctc cgcctcccag gttcaagtga
     4021 ttctcctgct tcagcctcct gagtagatgg gattgtaggc gtgcaccact gcacctggct
     4081 aatttttgta ttttcagtag agacggggtt tcaccatgtt ggtcaggctg gtctcaaact
     4141 cctgacctca agtgatctac ccgccttggc cttccatagt gctggcatta caggtgtaag
     4201 ccaccatgcc cctgcccaga tgcttgattt atactgtccc cacccaaacc ttgacttgct
     4261 cagcccaggg ggccagcagg gcagatcaag gcacggatgg tagttgtgtg tctgccgtaa
     4321 ttacccaagt tacttataat cgttgtgtta ctaggtaggt ttatttgaag atttatttat
     4381 ttatttattt attttttatt ttttgagacg gagtttcact cttgttgccc aggctggagt
     4441 gcagtggcat gatctcagct cactgcaacc tctgccttct gggttcacgt gattctcctg
     4501 cctcaggcct cccgagtagc tgggattaca ggtgccacca tgcctggtta attttttgta
     4561 tttttagtag agacggggtt tcatcatgtt ggccaggttg gtctcgaact cctgacctca
     4621 ggtgatccac ccgcctcagt ctaccaaagt gcagggatca caggcatgag cttccgcgct
     4681 cagcctattt gaagatttaa taacattttt caaacctcag gatgtatttg agtagattgc
     4741 ttctaaattg gtcacctaga aaataagtta tctatttact atgatacctg gattaagcct
     4801 ctagctattt tgcttttttc tttctatcta tattattgga tgattgatgc ctattttctg
     4861 tggttatgaa tatagacatt ttaaatgaaa gttggtatat aaatttttga aaataattgt
     4921 atttcctgtt ttatagtctt aggattaata tatgggattt atcttatgtt aatcttacat
     4981 ttaggatttt gtgaaaatgg aaaattatga ggcattggta ggctttgatc tctgtaatac
     5041 accgctctcc agtgttgctc agaagattat gtctgctatg cattcaggtg atttagtgga
     5101 ttctaagact tggggaaaga gtacagagag taagtaattt ttatgaacct ttctttctct
     5161 tgatactttg aatgttaatt gttctaaaga ctaagaattg aaaatggaat gcatgtagac
     5221 agatgaagcc cagctcccgc cccttttaca ctcattcagt gcagactgag cttctgcttg
     5281 ctaactttcg tgttccctta accttcattg ctttaaaaat gtaacactct cttccttatt
     5341 ccaggtattt ctgtcaaaca ttcccttaga atctggatca ggtattttag tattttcaaa
     5401 agagatgctt taatcttggt tctcaggtca tcaaacctgt acatagtatt tgctattttg
     5461 tgtggtgaac aagagatatg tttttgacaa tatgtgtatt gtgctgctat agaaatgtaa
     5521 actcttaggt ggcaaggatt attggatcag tgtatatgga tttatgatgt ggtataatag
     5581 taaaagcagt ggggccgggt gcggtggctc acgcctgtaa tcccagcact ttgggaggcc
     5641 gaggtcggcg atcatgaggt caggagatcg agaccatcct ggctaacacg gtaaaacact
     5701 gtctctacta aaaatacaaa aaattagctg ggagtggtgg taggcgcctg tagtccagct
     5761 acttgggagg ctgaggcagg agaatggcat gaacccagga ggcggggctt gcagtgagct
     5821 gaggtctcca gcgtgggcga cagagtgaga ctctatctca aaaaaaaaaa aaaaaaaaa
//
