LOCUS       NM_138443               1072 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens HAUS augmin like complex subunit 1 (HAUS1), transcript
            variant 1, mRNA.
ACCESSION   NM_138443 XM_938131
VERSION     NM_138443.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Liu,S., Yu,Y., Xu,J., Wang,Y. and Li,D.
  TITLE     Single-cell and bulk RNA-sequencing reveals mitosis-involved gene
            HAUS1 is a promising indicator for predicting prognosis and immune
            responses in prostate adenocarcinoma (PRAD)
  JOURNAL   Cell Biol Int 48 (8), 1169-1184 (2024)
   PUBMED   38818762
  REMARK    GeneRIF: Single-cell and bulk RNA-sequencing reveals
            mitosis-involved gene HAUS1 is a promising indicator for predicting
            prognosis and immune responses in prostate adenocarcinoma (PRAD).
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   7  (bases 1 to 1072)
  AUTHORS   Lawo,S., Bashkurov,M., Mullin,M., Ferreria,M.G., Kittler,R.,
            Habermann,B., Tagliaferro,A., Poser,I., Hutchins,J.R., Hegemann,B.,
            Pinchev,D., Buchholz,F., Peters,J.M., Hyman,A.A., Gingras,A.C. and
            Pelletier,L.
  TITLE     HAUS, the 8-subunit human Augmin complex, regulates centrosome and
            spindle integrity
  JOURNAL   Curr Biol 19 (10), 816-826 (2009)
   PUBMED   19427217
REFERENCE   8  (bases 1 to 1072)
  AUTHORS   Uehara,R., Nozawa,R.S., Tomioka,A., Petry,S., Vale,R.D., Obuse,C.
            and Goshima,G.
  TITLE     The augmin complex plays a critical role in spindle microtubule
            generation for mitotic progression and cytokinesis in human cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6998-7003 (2009)
   PUBMED   19369198
REFERENCE   9  (bases 1 to 1072)
  AUTHORS   Goshima,G., Mayer,M., Zhang,N., Stuurman,N. and Vale,R.D.
  TITLE     Augmin: a protein complex required for centrosome-independent
            microtubule generation within the spindle
  JOURNAL   J Cell Biol 181 (3), 421-429 (2008)
   PUBMED   18443220
REFERENCE   10 (bases 1 to 1072)
  AUTHORS   Einarson,M.B., Cukierman,E., Compton,D.A. and Golemis,E.A.
  TITLE     Human enhancer of invasion-cluster, a coiled-coil protein required
            for passage through mitosis
  JOURNAL   Mol Cell Biol 24 (9), 3957-3971 (2004)
   PUBMED   15082789
  REMARK    GeneRIF: These results place human enhancer of invasion-cluster as
            a novel regulator of spindle function and integrity during the
            metaphase-anaphase transition.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC014003.2.
            
            On Nov 23, 2018 this sequence version replaced NM_138443.3.
            
            Summary: HAUS1 is 1 of 8 subunits of the 390-kD human augmin
            complex, or HAUS complex. The augmin complex was first identified
            in Drosophila, and its name comes from the Latin verb 'augmentare,'
            meaning 'to increase.' The augmin complex is a microtubule-binding
            complex involved in microtubule generation within the mitotic
            spindle and is vital to mitotic spindle assembly (Goshima et al.,
            2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed
            19369198]).[supplied by OMIM, Jun 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014003.2, SRR1163658.312301.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282058.11/ ENSP00000282058.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1072              BC014003.2         27-1098
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..1072
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /note="HAUS augmin like complex subunit 1"
                     /db_xref="GeneID:115106"
                     /db_xref="HGNC:HGNC:25174"
                     /db_xref="MIM:608775"
     exon            1..57
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..864
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /note="coiled-coil domain containing 5 (spindle
                     associated); enhancer of invasion-cluster; coiled-coil
                     domain-containing protein 5"
                     /codon_start=1
                     /product="HAUS augmin-like complex subunit 1"
                     /protein_id="NP_612452.1"
                     /db_xref="CCDS:CCDS11928.1"
                     /db_xref="GeneID:115106"
                     /db_xref="HGNC:HGNC:25174"
                     /db_xref="MIM:608775"
                     /translation="MEPQEERETQVAAWLKKIFGDHPIPQYEVNPRTTEILHHLSERN
                     RVRDRDVYLVIEDLKQKASEYESEAKYLQDLLMESVNFSPANLSSTGSRYLNALVDSA
                     VALETKDTSLASFIPAVNDLTSDLFRTKSKSEEIKIELEKLEKNLTATLVLEKCLQED
                     VKKAELHLSTERAKVDNRRQNMDFLKAKSEEFRFGIKAAEEQLSARGMDASLSHQSLV
                     ALSEKLARLKQQTIPLKKKLESYLDLMPNPSLAQVKIEEAKRELDSIEAELTRRVDMM
                     EL"
     exon            58..232
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            233..368
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            369..503
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            504..627
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            628..693
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            694..765
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            766..813
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1072
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /note="hexamer: ATTAAA"
     polyA_site      1072
                     /gene="HAUS1"
                     /gene_synonym="CCDC5; HEI-C; HEIC; HsT1461"
                     /note="major polyA site"
ORIGIN      
        1 cctagtaaag tggcgggagc cgcagctatg gagccgcagg aggagagaga aacgcaggtt
       61 gctgcgtggt taaaaaaaat atttggagat catcctattc cacagtatga ggtgaaccca
      121 cggaccacag agattttaca tcacctttca gaacgcaaca gggtccggga cagggatgtc
      181 tacctggtaa tagaggactt gaagcagaaa gcaagtgaat acgagtcaga agccaagtat
      241 cttcaagacc ttctcatgga gagtgtgaat ttttcccccg ccaatctctc tagcactggt
      301 tccaggtatc tgaatgcttt ggttgacagt gcggtggccc ttgaaacaaa ggatacctcg
      361 ctagctagtt ttatccctgc agtgaatgat ttgacctctg atctctttcg taccaaatcc
      421 aaaagtgaag aaatcaagat tgaactggaa aaacttgaaa aaaatttaac tgcaacttta
      481 gtattagaaa aatgtctaca agaggatgtc aagaaagcag agttgcatct gtctacagaa
      541 agggccaaag ttgataatcg tcgtcagaac atggactttc taaaagcaaa gtcagaggaa
      601 ttcagatttg gaatcaaggc tgcagaggag caactttcag ccagaggcat ggatgcttct
      661 ctgtctcatc agtccttagt agcactatca gagaaactgg caagattaaa gcaacagact
      721 atacctttga agaaaaaatt ggagtcctat ttagacttaa tgccgaatcc gtctcttgct
      781 caagtgaaaa ttgaagaagc aaagcgagaa ctagatagca ttgaagctga acttacaaga
      841 agagtagaca tgatggaact gtgacaaaag ccaaataaac atccttttcc ctaacaaagt
      901 aaattgaata ggactttaca gagttctttt tcctcttggc atttcctaat aacaaaactt
      961 tctgtgttct tagattacag aatatcataa ttgatagaat atggtttctt actgtgtgtt
     1021 gcatttttgt gcccaaatac atagttttca tattaaaaag ccttttctct ta
//
