LOCUS       NM_003642               1634 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens histone acetyltransferase 1 (HAT1), transcript variant
            1, mRNA.
ACCESSION   NM_003642
VERSION     NM_003642.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Kou,F., Wu,L., Zheng,Y., Yi,Y., Ji,Z., Huang,Z., Guo,S. and Yang,L.
  TITLE     HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis
            and metastasis in lung adenocarcinoma
  JOURNAL   Oncogene 42 (46), 3407-3421 (2023)
   PUBMED   37794134
  REMARK    GeneRIF: HMGB1/SET/HAT1 complex-mediated SASH1 repression drives
            glycolysis and metastasis in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Guo,B., Zhang,S., Wang,S., Zhang,H., Fang,J., Kang,N., Zhen,X.,
            Zhang,Y., Zhou,J., Yan,G., Sun,H., Ding,L. and Liu,C.
  TITLE     Decreased HAT1 expression in granulosa cells disturbs oocyte
            meiosis during mouse ovarian aging
  JOURNAL   Reprod Biol Endocrinol 21 (1), 103 (2023)
   PUBMED   37907924
  REMARK    GeneRIF: Decreased HAT1 expression in granulosa cells disturbs
            oocyte meiosis during mouse ovarian aging.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Ortega,M.A., De Leon-Oliva,D., Garcia-Montero,C.,
            Fraile-Martinez,O., Boaru,D.L., Del Val Toledo Lobo,M.,
            Garcia-Tunon,I., Royuela,M., Garcia-Honduvilla,N., Bujan,J.,
            Guijarro,L.G., Alvarez-Mon,M. and Alvarez-Mon,M.A.
  TITLE     Understanding HAT1: A Comprehensive Review of Noncanonical Roles
            and Connection with Disease
  JOURNAL   Genes (Basel) 14 (4), 915 (2023)
   PUBMED   37107673
  REMARK    GeneRIF: Understanding HAT1: A Comprehensive Review of Noncanonical
            Roles and Connection with Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Capone,V., Della Torre,L., Carannante,D., Babaei,M., Altucci,L.,
            Benedetti,R. and Carafa,V.
  TITLE     HAT1: Landscape of Biological Function and Role in Cancer
  JOURNAL   Cells 12 (7), 1075 (2023)
   PUBMED   37048148
  REMARK    GeneRIF: HAT1: Landscape of Biological Function and Role in Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Sarkar,T., Dhar,S., Chakraborty,D., Pati,S., Bose,S., Panda,A.K.,
            Basak,U., Chakraborty,S., Mukherjee,S., Guin,A., Jana,K.,
            Sarkar,D.K. and Sa,G.
  TITLE     FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor
            Microenvironment by Inducing CCR4 Expression in Breast Cancer
  JOURNAL   Front Immunol 13, 740588 (2022)
   PUBMED   35222362
  REMARK    GeneRIF: FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor
            Microenvironment by Inducing CCR4 Expression in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Makowski,A.M., Dutnall,R.N. and Annunziato,A.T.
  TITLE     Effects of acetylation of histone H4 at lysines 8 and 16 on
            activity of the Hat1 histone acetyltransferase
  JOURNAL   J Biol Chem 276 (47), 43499-43502 (2001)
   PUBMED   11585814
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Marmorstein,R.
  TITLE     Structure of histone acetyltransferases
  JOURNAL   J Mol Biol 311 (3), 433-444 (2001)
   PUBMED   11492997
  REMARK    Review article
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Verreault,A., Kaufman,P.D., Kobayashi,R. and Stillman,B.
  TITLE     Nucleosomal DNA regulates the core-histone-binding subunit of the
            human Hat1 acetyltransferase
  JOURNAL   Curr Biol 8 (2), 96-108 (1998)
   PUBMED   9427644
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114745.6.
            
            On Nov 23, 2018 this sequence version replaced NM_003642.3.
            
            Summary: The protein encoded by this gene is a type B histone
            acetyltransferase (HAT) that is involved in the rapid acetylation
            of newly synthesized cytoplasmic histones, which are in turn
            imported into the nucleus for de novo deposition onto nascent DNA
            chains. Histone acetylation, particularly of histone H4, plays an
            important role in replication-dependent chromatin assembly.
            Specifically, this HAT can acetylate soluble but not nucleosomal
            histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A
            at lysine 5. Alternatively spliced transcript variants have been
            identified for this gene. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.357536.1,
                                           SRR1803611.237430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264108.5/ ENSP00000264108.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC114745.6         20306-20352
            48-152              AC114745.6         23382-23486
            153-228             AC114745.6         44553-44628
            229-349             AC114745.6         50726-50846
            350-529             AC114745.6         63183-63362
            530-651             AC114745.6         63632-63753
            652-756             AC114745.6         64254-64358
            757-863             AC114745.6         64688-64794
            864-1015            AC114745.6         74002-74153
            1016-1132           AC114745.6         77092-77208
            1133-1634           AC114745.6         81030-81531
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1634
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /note="histone acetyltransferase 1"
                     /db_xref="GeneID:8520"
                     /db_xref="HGNC:HGNC:4821"
                     /db_xref="MIM:603053"
     exon            1..47
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1300
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /EC_number="2.3.1.48"
                     /codon_start=1
                     /product="histone acetyltransferase type B catalytic
                     subunit"
                     /protein_id="NP_003633.2"
                     /db_xref="CCDS:CCDS2245.1"
                     /db_xref="GeneID:8520"
                     /db_xref="HGNC:HGNC:4821"
                     /db_xref="MIM:603053"
                     /translation="MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDL
                     ENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCV
                     EADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQ
                     IYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFAT
                     VGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAE
                     DPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMVIEAQQKFKINKQHARRVYEI
                     LRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEIS
                     MQHEQLEESFQELVEDYRRVIERLAQE"
     exon            48..152
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..228
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..349
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..529
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..651
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..756
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..863
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1015
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1132
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1634
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /note="hexamer: AATAAA"
     polyA_site      1579
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /note="major polyA site"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAT1"
                     /gene_synonym="KAT1"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="HAT1"
                     /gene_synonym="KAT1"
ORIGIN      
        1 gattcgtcct tcctcagccg cgggtgatcg tagctcggaa atggcgggat ttggtgctat
       61 ggagaaattt ttggtagaat ataagagtgc agtggagaag aaactggcag agtacaaatg
      121 taacaccaac acagcaattg aactaaaatt agttcgtttt cctgaagatc ttgaaaatga
      181 cattagaact ttctttcctg agtataccca tcaactcttt ggggatgatg aaactgcttt
      241 tggttacaag ggtctaaaga tcctgttata ctatattgct ggtagcctgt caacaatgtt
      301 ccgtgttgaa tatgcatcta aagttgatga gaactttgac tgtgtagagg cagatgatgt
      361 tgagggcaaa attagacaaa tcattccacc tggattttgc acaaacacga atgatttcct
      421 ttctttactg gaaaaggaag ttgatttcaa gccattcgga accttacttc atacctactc
      481 agttctcagt ccaacaggag gagaaaactt tacctttcag atatataagg ctgacatgac
      541 atgtagaggc tttcgagaat atcatgaaag gcttcagacc tttttgatgt ggtttattga
      601 aactgctagc tttattgacg tggatgatga aagatggcac tactttctag tatttgagaa
      661 gtataataag gatggagcta cgctctttgc gaccgtaggc tacatgacag tctataatta
      721 ctatgtgtac ccagacaaaa cccggccacg tgtaagtcag atgctgattt tgactccatt
      781 tcaaggtcaa ggccatggtg ctcaacttct tgaaacagtt catagatact acactgaatt
      841 tcctacagtt cttgatatta cagcggaaga tccatccaaa agctatgtga aattacgaga
      901 ctttgtgctt gtgaagcttt gtcaagattt gccctgtttt tcccgggaaa aattaatgca
      961 aggattcaat gaagatatgg tgatagaggc acaacagaag ttcaaaataa ataagcaaca
     1021 cgctagaagg gtttatgaaa ttcttcgact actggtaact gacatgagtg atgccgaaca
     1081 atacagaagc tacagactgg atattaaaag aagactaatt agcccatata agaaaaagca
     1141 gagagatctt gctaagatga gaaaatgtct cagaccagaa gaactgacaa accagatgaa
     1201 ccaaatagaa ataagcatgc aacatgaaca gctggaagag agttttcagg aactagtgga
     1261 agattaccgg cgtgttattg aacgacttgc tcaagagtaa agattatact gctctgtaca
     1321 ggaagcttgc aaattttctg tacaatgtgc tgtgaaaaat ctgatgactt taattttaaa
     1381 atcttgtgac attttgctta tactaaaagt tatctatctt tagttgaata ttttcttttg
     1441 gagagattgt atattttaaa atactgttta gagtttatga gcatatattg catttaaaga
     1501 aagataaagc ttctgaaata ctactgcaat tgcttccctt cttaaacagt ataataaatg
     1561 cttagttgtg atatgttaat gtgtgatgat atgattctta aatacttaca ataaacctca
     1621 ttcttaaata ctta
//
