LOCUS       NM_031965               2797 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens histone H3 associated protein kinase (HASPIN), mRNA.
ACCESSION   NM_031965
VERSION     NM_031965.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2797)
  AUTHORS   Chen,H., Liu,S., Wu,S., Nong,X., Liu,N. and Li,L.
  TITLE     GSG2 promotes progression of human endometrial cancer by regulating
            PD-1/PD-L1 expression via PI3K-AKT pathway
  JOURNAL   Int Immunopharmacol 134, 112196 (2024)
   PUBMED   38759367
  REMARK    GeneRIF: GSG2 promotes progression of human endometrial cancer by
            regulating PD-1/PD-L1 expression via PI3K-AKT pathway.
REFERENCE   2  (bases 1 to 2797)
  AUTHORS   Zhu,K., Ma,X., Guan,X., Tong,Y., Xie,S., Wang,Y., Zheng,H., Guo,L.
            and Lu,R.
  TITLE     Germ cell-specific gene 2 accelerates cell cycle in epithelial
            ovarian cancer by inhibiting GSK3alpha-p27 cascade
  JOURNAL   J Mol Histol 55 (3), 241-251 (2024)
   PUBMED   38613588
  REMARK    GeneRIF: Germ cell-specific gene 2 accelerates cell cycle in
            epithelial ovarian cancer by inhibiting GSK3alpha-p27 cascade.
REFERENCE   3  (bases 1 to 2797)
  AUTHORS   Zhang,F. and Huang,C.
  TITLE     GSG2 promotes thyroid cancer via stabilizing AURKB and activating
            AKT pathway
  JOURNAL   Aging (Albany NY) 16 (6), 5091-5107 (2024)
   PUBMED   38441546
  REMARK    GeneRIF: GSG2 promotes thyroid cancer via stabilizing AURKB and
            activating AKT pathway.
REFERENCE   4  (bases 1 to 2797)
  AUTHORS   Tang,Y., Dai,G., Yang,Y. and Liu,H.
  TITLE     GSG2 facilitates the progression of human breast cancer through
            MDM2-mediated ubiquitination of E2F1
  JOURNAL   J Transl Med 21 (1), 523 (2023)
   PUBMED   37537694
  REMARK    GeneRIF: GSG2 facilitates the progression of human breast cancer
            through MDM2-mediated ubiquitination of E2F1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2797)
  AUTHORS   Zhang,F., Qiu,B., Ji,Y., Zhang,H., Song,P., Sun,N., Zhao,L., Lv,F.,
            Yin,L., Gao,Y., Xue,Q., Gao,S. and He,J.
  TITLE     Knockdown of GSG2 inhibits the development and progression of
            non-small cell lung cancer in vitro and in vivo
  JOURNAL   Cell Cycle 22 (2), 153-164 (2023)
   PUBMED   35972887
  REMARK    GeneRIF: Knockdown of GSG2 inhibits the development and progression
            of non-small cell lung cancer in vitro and in vivo.
REFERENCE   6  (bases 1 to 2797)
  AUTHORS   Dai,J., Sullivan,B.A. and Higgins,J.M.
  TITLE     Regulation of mitotic chromosome cohesion by Haspin and Aurora B
  JOURNAL   Dev Cell 11 (5), 741-750 (2006)
   PUBMED   17084365
  REMARK    GeneRIF: Haspin is required to maintain centromeric cohesion during
            mitosis.
REFERENCE   7  (bases 1 to 2797)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 2797)
  AUTHORS   Dai,J., Sultan,S., Taylor,S.S. and Higgins,J.M.
  TITLE     The kinase haspin is required for mitotic histone H3 Thr 3
            phosphorylation and normal metaphase chromosome alignment
  JOURNAL   Genes Dev 19 (4), 472-488 (2005)
   PUBMED   15681610
  REMARK    GeneRIF: This work reveals a new kinase involved in composing the
            histone code and adds haspin to the select group of kinases that
            integrate regulation of chromosome and spindle function during
            mitosis and meiosis
REFERENCE   9  (bases 1 to 2797)
  AUTHORS   Higgins,J.M.
  TITLE     The Haspin gene: location in an intron of the integrin alphaE gene,
            associated transcription of an integrin alphaE-derived RNA and
            expression in diploid as well as haploid cells
  JOURNAL   Gene 267 (1), 55-69 (2001)
   PUBMED   11311556
REFERENCE   10 (bases 1 to 2797)
  AUTHORS   Tanaka,H., Iguchi,N., Nakamura,Y., Kohroki,J., de Carvalho,C.E. and
            Nishimune,Y.
  TITLE     Cloning and characterization of human haspin gene encoding haploid
            germ cell-specific nuclear protein kinase
  JOURNAL   Mol Hum Reprod 7 (3), 211-218 (2001)
   PUBMED   11228240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036181.1, BC016626.1, BC047457.1 and AF289865.1.
            
            On Dec 23, 2004 this sequence version replaced NM_031965.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC036181.1, AB039834.3 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325418.5/ ENSP00000325290.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1039              BC036181.1         1-1039
            1040-1165           BC016626.1         1026-1151
            1166-2245           BC036181.1         1165-2244
            2246-2501           BC047457.1         2227-2482
            2502-2793           BC036181.1         2501-2792
            2794-2797           AF289865.1         2790-2793
FEATURES             Location/Qualifiers
     source          1..2797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2797
                     /gene="HASPIN"
                     /gene_synonym="GSG2"
                     /note="histone H3 associated protein kinase"
                     /db_xref="GeneID:83903"
                     /db_xref="HGNC:HGNC:19682"
                     /db_xref="MIM:609240"
     exon            1..2797
                     /gene="HASPIN"
                     /gene_synonym="GSG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2430
                     /gene="HASPIN"
                     /gene_synonym="GSG2"
                     /EC_number="2.7.11.1"
                     /note="haploid germ cell-specific nuclear protein kinase;
                     H-haspin; germ cell-specific gene 2 protein; germ cell
                     associated 2, haspin"
                     /codon_start=1
                     /product="serine/threonine-protein kinase haspin"
                     /protein_id="NP_114171.2"
                     /db_xref="CCDS:CCDS11036.1"
                     /db_xref="GeneID:83903"
                     /db_xref="HGNC:HGNC:19682"
                     /db_xref="MIM:609240"
                     /translation="MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFF
                     NSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWK
                     LRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGD
                     ELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLP
                     CSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLV
                     VGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERT
                     RSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHK
                     KKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTL
                     SISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPV
                     AIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQ
                     GSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLAT
                     AKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQ
                     VSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYS
                     NVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
                     "
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HASPIN"
                     /gene_synonym="GSG2"
                     /note="hexamer: AATAAA"
     polyA_site      2797
                     /gene="HASPIN"
                     /gene_synonym="GSG2"
                     /note="major polyA site"
ORIGIN      
        1 gtttgcgttt gaacctcttg gcgggtgccg gccatggcgg cttcgctccc gggacctggg
       61 agccggcttt tccgcacata tggggctgcg gacggcagga gacagcggcg gccgggccgg
      121 gaagccgcgc agtggttccc gccgcaggac cggaggcgtt tcttcaacag cagcggcagc
      181 agcgacgcca gcatcggcga cccctcgcag tccgacgatc ctgacgatcc cgacgacccc
      241 gacttccccg gcagcccggt gaggcggcgg cggaggcgtc ccggcggccg agtgcccaag
      301 gaccggccca gcctgaccgt gaccccaaag cgctggaagc tgcgagctcg cccaagccta
      361 accgtgaccc caagacgcct ggggctgcga gctcggcccc cgcagaagtg cagcacaccc
      421 tgcggcccgc tccgacttcc gcccttcccc agccgcgact ccggccgcct cagcccggac
      481 ctcagcgtgt gcggccagcc cagggacggc gacgagctgg gcatcagtgc ctccctgttc
      541 agctctctgg cctcgccctg ccccgggtcc ccaacgccaa gggacagtgt catctcgatc
      601 ggcacctccg cctgtctggt tgcagcctca gccgtcccga gcggcctcca cctcccagaa
      661 gtctccctgg accgagcatc tctcccctgc tcccaggagg aagcgacagg aggagccaag
      721 gacaccagga tggtccacca aacccgcgcc agcctcaggt cagttctctt tggccttatg
      781 aactcaggaa cccctgagga ttctgagttt cgggcagatg ggaagaatat gagagagtcc
      841 tgctgtaaaa ggaaactggt ggtgggaaat ggaccagagg gtccaggtct gtcaagcaca
      901 ggcaagagga gggccacagg ccaggactct tgtcaagaga gagggcttca agaggccgtc
      961 cggagagagc atcaggaggc cagtgttccc aagggccgca ttgtgccaag gggaatagac
     1021 aggctggaga gaactagatc aagccggaag agcaaacatc aggaggcaac ggaaacctct
     1081 ctcctccatt cccaccgctt taaaaagggc caaaagctgg gaaaagattc gttccccacc
     1141 caggacctga ctcctttaca gaatgtctgc ttttggacca aaaccagggc ttccttcagt
     1201 ttccacaaga agaaaattgt gactgatgtg tcagaggtct gcagcatcta taccactgcc
     1261 acttctctct ctggatccct cctatcagaa tgttcaaacc ggcctgtcat gaacagaaca
     1321 agtggtgctc cgtcctcttg gcactcctcc tctatgtatt tgctaagccc cttaaacact
     1381 ctaagtattt caaacaaaaa ggcatctgat gctgaaaagg tttatgggga atgcagtcag
     1441 aagggtcctg tcccctttag ccattgcctt cccacagaaa aactgcaacg ctgtgagaag
     1501 attggggaag gggtgtttgg cgaagtgttt caaacaattg ctgatcacac acccgtagcc
     1561 ataaaaatca ttgctattga aggaccagat ttagtcaatg gatcccatca gaaaaccttt
     1621 gaggaaatcc tgccagagat catcatctcc aaagagttga gcctcttatc cggtgaagtg
     1681 tgcaaccgca cagaaggctt tatcgggctg aactcagtgc actgtgtcca gggatcttac
     1741 cctcccttgc tcctcaaagc ctgggatcac tataattcaa ccaaaggctc tgcaaatgac
     1801 cggcctgatt tttttaaaga cgaccagctc ttcattgtgc tggaatttga gtttggaggg
     1861 attgacttag agcaaatgcg aaccaagttg tcttccttgg ctactgcaaa gagcattcta
     1921 caccagctca cagcctccct cgcagtggca gaggcatcac tgcgctttga gcaccgagac
     1981 ttacactggg ggaacgtgct cttaaagaaa accagcctca aaaaactcca ctacaccctc
     2041 aatgggaaga gcagcactat ccccagctgt gggttgcaag tgagcatcat tgactacacc
     2101 ctgtcgcgct tggaacggga tgggattgtg gttttctgtg acgtttccat ggatgaggac
     2161 ctgtttaccg gtgacggtga ctaccagttt gacatctaca ggctcatgaa gaaggagaat
     2221 aacaaccgct ggggtgaata tcacccttat agtaatgtgc tctggttaca ttacctgaca
     2281 gacaagatgc tgaaacaaat gaccttcaag actaaatgta acactcctgc catgaagcaa
     2341 attaagagaa aaatccagga gttccacagg acaatgctga acttcagctc tgccactgac
     2401 ttgctctgcc agcacagtct gtttaagtaa gctaaatgta tcttactgcc ccgaaatgag
     2461 aggagactgg tcttgaagcc tctggtgctg tttcaacctc catccccaca ggagggtgga
     2521 actcccattc tcacaggttt ccagtcagct tttcaaacaa gaattttgtt tccaaatgga
     2581 aactgaaata tttgttgaaa tgtttaaatt tgctgataac aaatgttctg aaagaagtaa
     2641 actagccggg cacagtggcg tgcgcctgta gtcccagcta ctcgggaggc tgaggcagga
     2701 ggatcgcttg agcccaagag ttcatatcta gcctggtcaa catagcaaga cccctgtctc
     2761 tattttttta aataaataaa ctacatgtga aaacaaa
//
