LOCUS       NM_173811               1967 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens harbinger transposase derived 1 (HARBI1), mRNA.
ACCESSION   NM_173811
VERSION     NM_173811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Ferreira,R.C., Pan-Hammarstrom,Q., Graham,R.R., Gateva,V.,
            Fontan,G., Lee,A.T., Ortmann,W., Urcelay,E., Fernandez-Arquero,M.,
            Nunez,C., Jorgensen,G., Ludviksson,B.R., Koskinen,S., Haimila,K.,
            Clark,H.F., Klareskog,L., Gregersen,P.K., Behrens,T.W. and
            Hammarstrom,L.
  TITLE     Association of IFIH1 and other autoimmunity risk alleles with
            selective IgA deficiency
  JOURNAL   Nat Genet 42 (9), 777-780 (2010)
   PUBMED   20694011
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Sinzelle,L., Kapitonov,V.V., Grzela,D.P., Jursch,T., Jurka,J.,
            Izsvak,Z. and Ivics,Z.
  TITLE     Transposition of a reconstructed Harbinger element in human cells
            and functional homology with two transposon-derived cellular genes
  JOURNAL   Proc Natl Acad Sci U S A 105 (12), 4715-4720 (2008)
   PUBMED   18339812
  REMARK    GeneRIF: The functions of two transposon-derived human proteins:
            HARBI1, a domesticated transposase-derived protein, and NAIF1,
            which contains a trihelix motif similar to that described in the
            Myb-like protein, was investigated.
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Kapitonov,V.V. and Jurka,J.
  TITLE     Harbinger transposons and an ancient HARBI1 gene derived from a
            transposase
  JOURNAL   DNA Cell Biol 23 (5), 311-324 (2004)
   PUBMED   15169610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057237.1, BM768489.1 and AC127035.6.
            
            On May 17, 2019 this sequence version replaced NM_173811.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057237.1, SRR1803617.153363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326737.3/ ENSP00000317743.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1515              AK057237.1         1-1515
            1516-1522           BM768489.1         394-400
            1523-1967           AC127035.6         83111-83555         c
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1967
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /note="harbinger transposase derived 1"
                     /db_xref="GeneID:283254"
                     /db_xref="HGNC:HGNC:26522"
                     /db_xref="MIM:615086"
     exon            1..104
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /inference="alignment:Splign:2.1.0"
     exon            105..918
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1298
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /EC_number="3.1.-.-"
                     /note="harbinger transposase-derived nuclease"
                     /codon_start=1
                     /product="putative nuclease HARBI1"
                     /protein_id="NP_776172.1"
                     /db_xref="CCDS:CCDS7920.1"
                     /db_xref="GeneID:283254"
                     /db_xref="HGNC:HGNC:26522"
                     /db_xref="MIM:615086"
                     /translation="MAIPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQ
                     FIYYLVELLGANLSRPTQRSRAISPETQVLAALGFYTSGSFQTRMGDAIGISQASMSR
                     CVANVTEALVERASQFIRFPADEASIQALKDEFYGLAGMPGVMGVVDCIHVAIKAPNA
                     EDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHK
                     DSWLLGDSSFFLRTWLMTPLHIPETPAEYRYNMAHSATHSVIEKTFRTLCSRFRCLDG
                     SKGALQYSPEKSSHIILACCVLHNISLEHGMDVWSSPMTGPMEQPPEEEYEHMESLDL
                     EADRIRQELMLTHFS"
     exon            919..1967
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /note="hexamer: ATTAAA"
     polyA_site      1506
                     /gene="HARBI1"
                     /gene_synonym="C11orf77"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgcgcc gtggcggcct ctgtgcagtc gccggttccg gaggagggcc caacccggct
       61 gggtgggtgg gaagtgtggc tggtaacctg gcagccgcgg agagagagaa gattataaat
      121 ggcagagcca tttaactgtg gttagctgtt ggattctgat actttcttaa aaatacgttc
      181 ttgcaccaac atcttcattg ggaacagttc agaaaaagca aagaggagag ccaacattca
      241 catttaccat ggctatacca ataacagtgc ttgactgtga cctcttgcta tatggccgtg
      301 gtcaccggac attggaccgt tttaagctgg atgatgtgac tgatgaatac ttgatgtcca
      361 tgtatgggtt tccacggcag ttcatttatt acttggtgga gctcttgggg gcgaatcttt
      421 ctaggcctac tcagcgatcc agggctatta gcccagagac acaggtcctt gcagcattgg
      481 gtttttatac ctcaggttcc ttccagactc ggatgggaga tgccattgga atcagtcagg
      541 cgtctatgag tcgttgtgtt gccaatgtca ctgaagcact tgtggaaagg gcctcacagt
      601 tcattcgctt tccagctgat gaagcctcca ttcaggctct gaaggatgaa ttctatgggt
      661 tggcagggat gccaggggtg atgggggtgg ttgactgtat ccatgtggcc atcaaggcac
      721 caaatgctga agacctctcc tatgtgaacc gaaaaggcct gcattcttta aactgcctga
      781 tggtgtgtga cattagaggg acactaatga ccgtggagac aaactggccc ggcagcctac
      841 aggactgtgc tgtgctgcag cagtcttccc tcagtagtca gtttgaagcg ggtatgcaca
      901 aagatagctg gcttctgggt gacagttcct tctttcttcg aacctggctc atgaccccac
      961 ttcacattcc tgaaactcca gcagaatatc gctataacat ggcccattct gcaactcaca
     1021 gtgtgattga gaagactttc cgaaccctct gctcccgatt ccgctgcctg gatggatcca
     1081 agggggcact gcagtactca ccagagaaat ccagccatat catcttggcc tgttgtgtcc
     1141 tccacaacat ctccctggag catgggatgg atgtttggtc ctctccaatg acaggaccca
     1201 tggaacagcc cccggaagag gagtatgagc acatggagtc cctggactta gaggctgacc
     1261 gtattcgtca ggagctaatg ctcactcatt ttagctaatg tagaaggtgg agaggaggga
     1321 tacttcccag gagttgtgac agactttcct cctcatcacc ttttacacag ttccatcatc
     1381 tagcatgact gagtatacag atacttgtca taaactgaca tttaatatgt gtgttttggt
     1441 aaggttgggg ctatgccaga atatcttgat tcatttgcat atgcattaat taaactgaaa
     1501 ccaagacagc ggctccctac tatccagtga actctaggtt gagtaccact aatttgaaag
     1561 ctcagtggtt gcaaacattt atgactgtgc ctacaaagtc atagtaaagg tcaggagttc
     1621 aagacaagac cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt
     1681 agcggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc
     1741 ggatcacctg agttcaggag ttaagaccag cctgggcaac atggcaagac cctgtctcta
     1801 ctaaaaatac aaaaaaatta gctgggcgtg gtgacaggtg cctgtaatcc cagctactcg
     1861 gtaggctgag gcaggagaat cacttgaacc agggaggcgg aggttgtggt gagccgagat
     1921 cgtgccattg cactccagcc taggcaagaa gagcgaaact ccgtctc
//
