LOCUS       NM_001271560            1234 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens HUWE1 associated protein modifying stress responses 2
            (HAPSTR2), mRNA.
ACCESSION   NM_001271560
VERSION     NM_001271560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Amici,D.R., Cingoz,H., Alasady,M.J., Alhayek,S., Phoumyvong,C.M.,
            Sahni,N., Yi,S.S. and Mendillo,M.L.
  TITLE     The HAPSTR2 retrogene buffers stress signaling and resilience in
            mammals
  JOURNAL   Nat Commun 14 (1), 152 (2023)
   PUBMED   36631436
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589987.25.
            
            On Jan 5, 2021 this sequence version replaced NM_001271560.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR3218374.164847.1, ERR3218376.91164.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453380.3/ ENSP00000506518.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1234              AL589987.25        111995-113228
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.1"
     gene            1..1234
                     /gene="HAPSTR2"
                     /note="HUWE1 associated protein modifying stress responses
                     2"
                     /db_xref="GeneID:389895"
                     /db_xref="HGNC:HGNC:55138"
     exon            1..1234
                     /gene="HAPSTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..887
                     /gene="HAPSTR2"
                     /note="chromosome 16 open reading frame 72-like"
                     /codon_start=1
                     /product="HUWE1-associated protein modifying stress
                     responses 2"
                     /protein_id="NP_001258489.1"
                     /db_xref="CCDS:CCDS94678.1"
                     /db_xref="GeneID:389895"
                     /db_xref="HGNC:HGNC:55138"
                     /translation="MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAA
                     ELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESG
                     DAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRT
                     PPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVA
                     SSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAPSTR2"
                     /note="hexamer: AATAAA"
     polyA_site      1234
                     /gene="HAPSTR2"
                     /note="major polyA site"
ORIGIN      
        1 agtaggcagc agcggcggcg gcggaggagg aggcggtggt ggaggtgcgc ggcctgaaga
       61 ggaggatgga ggagcagcag aaggagggcg aggccgaggt cgcggagcac tggttttcca
      121 agtgggagcg ccagtgcctg gctgaggccg agcaggagga gcagctgccc cccgagctgc
      181 aggaggaggc ggctgcagag ttggcagggc tcaagagcga gaagcagaag ctgtggcacc
      241 tcttccagat ctcggccacc gccgttgctc agctttacaa ggattctggg tgccaacagc
      301 aaggactttc catgtgggac cccttccaga atgcggccat ggccgtgacc agcctctaca
      361 aagagagcgg ggatgcccac caacgaagtt ttgacttggg tgtccaggtt ggccaccagc
      421 gtcgcatcaa agatgtgctg gagtgggtga aaaagggccg gagcaccatt cgtcgcgaag
      481 acttgattag cttcctgtgt ggcaaagtgc cccccgctcc tcctccacct cgcactccta
      541 ggacaccccc gaagccaccc actggggtca ccagccaggc tgtggcaact gagtccagct
      601 catcggtgga cgtcgacctg cagcccttcc aggaggcgat cgccctgcat ggcctcagtg
      661 gtgctatggc cggcatcagc atgcgatcgg gcgactcgcc tcaagacagc ggtgtcgcca
      721 gcagtgggcg ccgaaaaact agcttcttgg aggacgactt gaatcccttc gactcagagg
      781 aactggccct ccacctggac agtgggggga tccgcaagcg cacctcggcc caatgcagtg
      841 atggcatcac agactcccca atccaaaagc gcaaccgaat ggtctaaact gcctcattgg
      901 ttgcctgccg ccatattgct tgagagtgaa ctcaaccgtc gacatgcttg tctaaaggtt
      961 actggagacc atttttcttc ccttctctaa gttaaacaaa gatttctaac aattttgcca
     1021 taaagaaact ttaaaagtat tccagaagag gcttcatatg actctgactt tccaaaaaat
     1081 ataatcctag cagagaacaa atatgtagta gttagcagga tcatttaaag caaacgtatc
     1141 tggtcaaggc aggagtctga tttatcttgt tcacagttat attcctcagc acctagcaca
     1201 gttccaggtg ctcaataaat gttcattgaa tgaa
//
