LOCUS       NM_021817               1650 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens hyaluronan and proteoglycan link protein 2 (HAPLN2),
            mRNA.
ACCESSION   NM_021817
VERSION     NM_021817.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Kahler,A.K., Djurovic,S., Rimol,L.M., Brown,A.A., Athanasiu,L.,
            Jonsson,E.G., Hansen,T., Gustafsson,O., Hall,H., Giegling,I.,
            Muglia,P., Cichon,S., Rietschel,M., Pietilainen,O.P., Peltonen,L.,
            Bramon,E., Collier,D., St Clair,D., Sigurdsson,E., Petursson,H.,
            Rujescu,D., Melle,I., Werge,T., Steen,V.M., Dale,A.M.,
            Matthews,R.T., Agartz,I. and Andreassen,O.A.
  TITLE     Candidate gene analysis of the human natural killer-1 carbohydrate
            pathway and perineuronal nets in schizophrenia: B3GAT2 is
            associated with disease risk and cortical surface area
  JOURNAL   Biol Psychiatry 69 (1), 90-96 (2011)
   PUBMED   20950796
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Sim,H., Hu,B. and Viapiano,M.S.
  TITLE     Reduced expression of the hyaluronan and proteoglycan link proteins
            in malignant gliomas
  JOURNAL   J Biol Chem 284 (39), 26547-26556 (2009)
   PUBMED   19633295
  REMARK    GeneRIF: Results indicate that HAPLN4 and HAPLN2 are the
            predominant members of this family in the adult human brain but are
            strongly reduced in the tumor parenchyma.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Marangoni,S., Novello,J.C., Maccarrone,G., Turck,C.W. and
            Dias-Neto,E.
  TITLE     Alterations in oligodendrocyte proteins, calcium homeostasis and
            new potential markers in schizophrenia anterior temporal lobe are
            revealed by shotgun proteome analysis
  JOURNAL   J Neural Transm (Vienna) 116 (3), 275-289 (2009)
   PUBMED   19034380
  REMARK    GeneRIF: This protein has been found differentially expressed in
            the temporal lobe from patients with schizophrenia.
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Spicer,A.P., Joo,A. and Bowling,R.A. Jr.
  TITLE     A hyaluronan binding link protein gene family whose members are
            physically linked adjacent to chondroitin sulfate proteoglycan core
            protein genes: the missing links
  JOURNAL   J Biol Chem 278 (23), 21083-21091 (2003)
   PUBMED   12663660
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Nomoto,H., Oohashi,T., Hirakawa,S., Ueki,Y., Ohtsuki,H. and
            Ninomiya,Y.
  TITLE     Human BRAL1 and BCAN genes that belong to the link-module
            superfamily are tandemly arranged on chromosome 1q21-23
  JOURNAL   Acta Med Okayama 56 (1), 25-29 (2002)
   PUBMED   11873941
  REMARK    GeneRIF: gene locus at chromosome 1q21-23.
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Oohashi,T., Hirakawa,S., Bekku,Y., Rauch,U., Zimmermann,D.R.,
            Su,W.D., Ohtsuka,A., Murakami,T. and Ninomiya,Y.
  TITLE     Bral1, a brain-specific link protein, colocalizing with the
            versican V2 isoform at the nodes of Ranvier in developing and adult
            mouse central nervous systems
  JOURNAL   Mol Cell Neurosci 19 (1), 43-57 (2002)
   PUBMED   11817897
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Hirakawa,S., Oohashi,T., Su,W.D., Yoshioka,H., Murakami,T.,
            Arata,J. and Ninomiya,Y.
  TITLE     The brain link protein-1 (BRAL1): cDNA cloning, genomic structure,
            and characterization as a novel link protein expressed in adult
            brain
  JOURNAL   Biochem Biophys Res Commun 276 (3), 982-989 (2000)
   PUBMED   11027579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB049054.1 and BC029864.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021817.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049054.1, SRR3476690.963142.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255039.6/ ENSP00000255039.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1442              AB049054.1         122-1563
            1443-1647           BC029864.1         1361-1565
            1648-1650           AB049054.1         1769-1771
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..1650
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /note="hyaluronan and proteoglycan link protein 2"
                     /db_xref="GeneID:60484"
                     /db_xref="HGNC:HGNC:17410"
                     /db_xref="MIM:619726"
     exon            1..121
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..262
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..371
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1309
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /note="brain link protein-1"
                     /codon_start=1
                     /product="hyaluronan and proteoglycan link protein 2
                     precursor"
                     /protein_id="NP_068589.1"
                     /db_xref="CCDS:CCDS1148.1"
                     /db_xref="GeneID:60484"
                     /db_xref="HGNC:HGNC:17410"
                     /db_xref="MIM:619726"
                     /translation="MPGWLTLPTLCRFLLWAFTIFHKAQGDPASHPGPHYLLPPIHEV
                     IHSHRGATATLPCVLGTTPPSYKVRWSKVEPGELRETLILITNGLHARGYGPLGGRAR
                     MRRGHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQ
                     FNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGR
                     GRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVG
                     HLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGT
                     YCYAEN"
     exon            372..725
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..842
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1025
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1650
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="HAPLN2"
                     /gene_synonym="BRAL1"
                     /note="major polyA site"
ORIGIN      
        1 agacagacag ggggttgtac agaagaggtc cggtttcttg aagcagctgg aagtcctgga
       61 tagttcccac ctgaaagtct gtttgcaaag gcaatgcgca ctcaggcacc agagggcaga
      121 ggggctcaag ttccagggtt ttaaggtgct tggaactccc aggagcctgg caaaccttca
      181 tccagaacct cttcctcaag caagacaaaa agctgctaag cactgctccc tccgtctctg
      241 tgaagagacc agcttctaac agacggtgcc gggctgaccc cccatcatgc caggctggct
      301 caccctcccc acactctgcc gcttccttct ttgggccttc accatcttcc acaaagccca
      361 aggagaccca gcatcccacc cgggccccca ctacctcctg ccccccatcc acgaggtcat
      421 tcactctcat cgtggggcca cggccacgct gccctgcgtc ctgggcacca cgcctcccag
      481 ctacaaggtg cgctggagca aggtggagcc tggggagctc cgggaaacgc tgatcctcat
      541 caccaacgga ctgcacgccc gggggtatgg gcccctggga gggcgcgcca ggatgcggag
      601 ggggcatcga ctagacgcct ccctggtcat cgcgggcgtg cgcctggagg acgagggccg
      661 gtaccgctgc gagctcatca acggcatcga ggacgagagc gtggcgctga ccttgagctt
      721 ggagggtgtg gtgtttccgt accaacccag ccggggccgg taccagttca attactacga
      781 ggcgaagcag gcgtgcgagg agcaggacgg acgcctggcc acctactccc agctctacca
      841 ggcttggacc gagggtctgg actggtgtaa cgcgggctgg ctgctcgagg gctccgtgcg
      901 ctaccctgtg ctcaccgcac gcgccccgtg cggcggccga ggccggcccg ggatccgcag
      961 ctacggaccc cgcgaccgga tgcgcgaccg ctacgacgcc ttctgcttca cctccgcgct
     1021 ggcgggccaa gtgttcttcg tgcccgggcg gctgacgctg tctgaagccc acgcggcgtg
     1081 ccggcgacgc ggcgccgtgg tggccaaggt tgggcacctc tacgccgcct ggaagttttc
     1141 ggggctagac cagtgcgacg gcggctggct ggctgacggc agtgtgcgct tcccaatcac
     1201 cacgccgagg ccgcgctgcg gggggctccc ggatcccgga gtgcgcagtt tcggcttccc
     1261 caggccccaa caggcagcct atgggaccta ctgctacgcc gagaattagg cgcccaccgt
     1321 gtcccctcca gcgcgcgcga agaagcttgg gagtcgtggc gggggtctct cgccacccct
     1381 ttccggagag cctcccctcc ctccagaccc ggagcggcct ctccagacct gccttcccag
     1441 ccgggggctg cgggcctcgg accccggctg gcccggcggc ggggagggga ggcgggggcg
     1501 cctccggcgg cgagatgcag aggtgaccct cggacccgct gccgttcgcg aaccctagca
     1561 gaggactcag ccaccgccgg ggggagggtg aggcggccgg gggcattaac tgacctctga
     1621 gtacagcaat aaaataacct ggggatcttt
//
