LOCUS       NM_032304               1512 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens hydroxyacylglutathione hydrolase like (HAGHL),
            transcript variant 2, mRNA.
ACCESSION   NM_032304
VERSION     NM_032304.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Xu,Y., Zhou,X., Gao,L., Yan,S., Li,Z., Zhang,D., Pu,J., Zou,S. and
            Mao,Z.
  TITLE     Identification of HAGHL as a novel metabolic oncogene regulating
            human colorectal cancer progression
  JOURNAL   Clin Transl Oncol 25 (4), 1033-1042 (2023)
   PUBMED   36417085
  REMARK    GeneRIF: Identification of HAGHL as a novel metabolic oncogene
            regulating human colorectal cancer progression.
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z98258.1, AK293575.1, BC004353.1 and BX090134.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032304.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004353.1, SRR1163655.117206.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000389703.8/
                                                  ENSP00000374353.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               Z98258.1           8772-8911
            141-165             AK293575.1         1-25
            166-1485            BC004353.1         1-1320
            1486-1512           BX090134.1         15-41               c
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1512
                     /gene="HAGHL"
                     /note="hydroxyacylglutathione hydrolase like"
                     /db_xref="GeneID:84264"
                     /db_xref="HGNC:HGNC:14177"
     exon            1..509
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1253
                     /gene="HAGHL"
                     /EC_number="3.1.2.6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hydroxyacylglutathione hydrolase-like protein; GLO2-like/
                     RJD12"
                     /codon_start=1
                     /product="hydroxyacylglutathione hydrolase-like protein
                     isoform 2"
                     /protein_id="NP_115680.1"
                     /db_xref="CCDS:CCDS32354.1"
                     /db_xref="GeneID:84264"
                     /db_xref="HGNC:HGNC:14177"
                     /translation="MKVKVIPVLEDNYMYLVIEELTREAVAVDVAVPKRLLEIVGREG
                     VSLTAVLTTHHHWDHARGNPELARLRPGLAVLGADERIFSLTRRLAHGEELRFGAIHV
                     RCLLTPGHTAGHMSYFLWEDDCPDPPALFSGDALSVAGCGSCLEGSAQQMYQSLAELG
                     TLPPETKVFCGHEHTLSNLEFAQKVEPCNDHVRAKLSWAKKRDEDDVPTVPSTLGEER
                     LYNPFLRVAEEPVRKFTGKAVPADVLEALCKERARFEQAGEPRQPQARALLALQWGLL
                     SAAPHD"
     exon            510..574
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            575..692
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            693..801
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            802..902
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1004
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1084
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1512
                     /gene="HAGHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAGHL"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="HAGHL"
                     /note="major polyA site"
ORIGIN      
        1 agtctgtcct tcgggtcctc agcacagccg tgccggtgag gcgggcggcg ggggaacgcg
       61 gctgtcccgg gtcaggggtc ttgcggcggc agggcggggg gccgaggggc ggggcctggg
      121 aggaaggcgt ggcctttggg gactggggct cggactgggg gcggagccgg ggctggttgg
      181 ggaccggccg ggttccgctc ctgctggagc ccggtgcgtg gaattccacg cgagtgccgg
      241 ggagttcctg gggagccggg cttctctttt ggcccccagc gtgttgaccg agcccgcttc
      301 gcacagccct tcctagggtg tggagagcgg gccccgccct gaaggggcac cgtgggctgg
      361 ggggcctgtt ttggagcagg caccggtggc cgagctccgt gaccatgaag gtcaaggtca
      421 tccccgtgct cgaggacaac tacatgtacc tggtcatcga ggagctcacg cgcgaggcgg
      481 tggccgtgga cgtggctgtg cccaagaggc tgctggagat cgtgggccgg gagggggtgt
      541 ctctgaccgc tgtgctgacc acccaccatc actgggacca cgcgcgggga aacccggagc
      601 tggcgcggct tcgtcccggg ctggcggtgc tgggcgcgga cgagcgcatc ttctcgctga
      661 cgcgcaggct ggcgcacggc gaggagctgc ggttcggggc catccacgtg cgttgcctcc
      721 tgacgcccgg ccacaccgcc ggccacatga gctacttcct gtgggaggac gattgcccgg
      781 acccacccgc cctgttctcg ggcgacgcgc tgtcggtggc cggctgcggc tcgtgcctgg
      841 agggcagcgc ccagcagatg taccagagcc tggccgagct gggtaccctg ccccccgaga
      901 cgaaggtgtt ctgcggccac gagcacacgc ttagcaacct ggagtttgcc cagaaagtgg
      961 agccctgcaa cgaccacgtg agagccaagc tgtcctgggc taagaagagg gatgaggatg
     1021 acgtgcccac tgtgccgtcg actctgggcg aggagcgcct ctacaacccc ttcctgcggg
     1081 tggcagagga gccggtgcgc aagttcacgg gcaaggcggt ccccgccgac gtcctggagg
     1141 cgctatgcaa ggagcgggcg cgcttcgaac aggcgggcga gccgcggcag ccacaggcgc
     1201 gggccctcct tgcgctgcag tgggggctcc tgagtgcagc cccacacgac tgagccaccc
     1261 agaccctcac agggctgggg cctgcgtccc tcctcgtgac ctcggccagc tggacccaca
     1321 tgagggccac ctctggaacc ttcttcgagg ccctggccag ccatctgccc agcctcggag
     1381 ggtgggcaac ctggtgcttc ccgggtggac acacaggacc actcagtggg gcctgtgtgg
     1441 gcgccgagac ctgggtgtct gggaagtggg gcacacgggg cctccgaact atgaataaag
     1501 ctttgaaagg cc
//
