LOCUS       NM_016395               3228 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens 3-hydroxyacyl-CoA dehydratase 3 (HACD3), transcript
            variant 1, mRNA.
ACCESSION   NM_016395 XM_940538
VERSION     NM_016395.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3228)
  AUTHORS   Li,Q., Jiang,L., Wang,Y., Liu,X., Wang,B., Shan,Z., Wang,Y.H.,
            Wang,Y., Chen,H. and Li,C.
  TITLE     HACD3 Prevents PB1 from Autophagic Degradation to Facilitate the
            Replication of Influenza A Virus
  JOURNAL   Viruses 16 (5), 702 (2024)
   PUBMED   38793585
  REMARK    GeneRIF: HACD3 Prevents PB1 from Autophagic Degradation to
            Facilitate the Replication of Influenza A Virus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3228)
  AUTHORS   Huang,Z.J., Li,Y.J., Yang,J., Huang,L., Zhao,Q., Lu,Y.F., Hu,Y.,
            Zhang,W.X., Liang,J.Z., Pan,J., Pan,Y.L., He,Q.Y. and Wang,Y.
  TITLE     PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate
            Epithelial-Mesenchymal and Mitofusion-Fission Transitions in
            Colorectal Cancer
  JOURNAL   Int J Biol Sci 20 (6), 2202-2218 (2024)
   PUBMED   38617530
  REMARK    GeneRIF: PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate
            Epithelial-Mesenchymal and Mitofusion-Fission Transitions in
            Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3228)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3228)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3228)
  AUTHORS   Matos,A.M., Pinto,F.R., Barros,P., Amaral,M.D., Pepperkok,R. and
            Matos,P.
  TITLE     Inhibition of calpain 1 restores plasma membrane stability to
            pharmacologically rescued Phe508del-CFTR variant
  JOURNAL   J Biol Chem 294 (36), 13396-13410 (2019)
   PUBMED   31324722
REFERENCE   6  (bases 1 to 3228)
  AUTHORS   Taguwa,S., Okamoto,T., Abe,T., Mori,Y., Suzuki,T., Moriishi,K. and
            Matsuura,Y.
  TITLE     Human butyrate-induced transcript 1 interacts with hepatitis C
            virus NS5A and regulates viral replication
  JOURNAL   J Virol 82 (6), 2631-2641 (2008)
   PUBMED   18160438
  REMARK    GeneRIF: results suggest that hB-ind1 plays a crucial role in HCV
            RNA replication and the propagation of JFH1 virus through
            interaction with viral and host proteins
REFERENCE   7  (bases 1 to 3228)
  AUTHORS   Sabbah,M., Saucier,C. and Redeuilh,G.
  TITLE     Human B-ind1 gene promoter: cloning and regulation by histone
            deacetylase inhibitors
  JOURNAL   Gene 374, 128-133 (2006)
   PUBMED   16516406
  REMARK    GeneRIF: The structure of the B-IND1 gene promoter region was
            determined.
REFERENCE   8  (bases 1 to 3228)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 3228)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3228)
  AUTHORS   Courilleau,D., Chastre,E., Sabbah,M., Redeuilh,G., Atfi,A. and
            Mester,J.
  TITLE     B-ind1, a novel mediator of Rac1 signaling cloned from sodium
            butyrate-treated fibroblasts
  JOURNAL   J Biol Chem 275 (23), 17344-17348 (2000)
   PUBMED   10747961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011846.16 and AC027220.10.
            
            On Nov 22, 2018 this sequence version replaced NM_016395.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.177699.1, AK074898.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261875.10/ ENSP00000261875.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC011846.16        119582-119837
            257-299             AC011846.16        140795-140837
            300-373             AC011846.16        144006-144079
            374-538             AC011846.16        145858-146022
            539-590             AC027220.10        10156-10207
            591-701             AC027220.10        14250-14360
            702-829             AC027220.10        15691-15818
            830-942             AC027220.10        21567-21679
            943-1049            AC027220.10        23024-23130
            1050-1181           AC027220.10        23711-23842
            1182-3228           AC027220.10        27779-29825
FEATURES             Location/Qualifiers
     source          1..3228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..3228
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /note="3-hydroxyacyl-CoA dehydratase 3"
                     /db_xref="GeneID:51495"
                     /db_xref="HGNC:HGNC:24175"
                     /db_xref="MIM:615940"
     exon            1..256
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1258
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /EC_number="4.2.1.134"
                     /note="isoform 1 is encoded by transcript variant 1;
                     butyrate-induced transcript 1; protein tyrosine
                     phosphatase-like protein PTPLAD1; butyrate-induced protein
                     1; protein-tyrosine phosphatase-like A domain-containing
                     protein 1; very-long-chain
                     (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3;
                     very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3;
                     protein tyrosine phosphatase-like A domain containing 1"
                     /codon_start=1
                     /product="very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 3 isoform 1"
                     /protein_id="NP_057479.2"
                     /db_xref="CCDS:CCDS45282.1"
                     /db_xref="GeneID:51495"
                     /db_xref="HGNC:HGNC:24175"
                     /db_xref="MIM:615940"
                     /translation="MENQVLTPHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKA
                     QGHGAKGDNVYEFHLEFLDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLF
                     LAPDFDRWLDESDAEMELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLG
                     FSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSL
                     IQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTW
                     LRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIM
                     IFLGLYINFRHLYKQRRRRYGQKKKKIH"
     exon            257..299
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..373
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..538
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..590
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..701
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..829
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..942
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1049
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1181
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..3228
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /note="hexamer: ATTAAA"
     polyA_site      3228
                     /gene="HACD3"
                     /gene_synonym="B-IND1; BIND1; HSPC121; PTPLAD1"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgcgc aggcgcggcc cgcgagcgtg gggtatctcg aggtgccggg ttgcaggcgc
       61 tcaggagcgc tagggtttga ggcctgcttt ctgctcgcgc cagcagagca ctacctgagg
      121 cagcgaggcg cagcgagcct agcctccccg cgccctgggc agtgtggcca tggagaatca
      181 ggtgttgacg ccgcatgtct actgggctca gcgacaccgc gagctatatc tgcgcgtgga
      241 gctgagtgac gtacagaacc ctgccatcag catcactgaa aacgtgctgc atttcaaagc
      301 tcaaggacat ggtgccaaag gagacaatgt ctatgaattt cacctggagt tcttagacct
      361 tgtgaaacca gagcctgttt acaaactgac ccagaggcag gtaaacatta cagtacagaa
      421 gaaagtgagt cagtggtggg agagactcac aaagcaggaa aagcgaccac tgtttttggc
      481 tcctgacttt gatcgttggc tggatgaatc tgatgcggaa atggagctca gagctaagga
      541 agaagagcgc ctaaataaac tccgactgga aagcgaaggc tctcctgaaa ctcttacaaa
      601 cttaaggaaa ggatacctgt ttatgtataa tcttgtgcaa ttcttgggat tctcctggat
      661 ctttgtcaac ctgactgtgc gattctgtat cttgggaaaa gagtcctttt atgacacatt
      721 ccatactgtg gctgacatga tgtatttctg ccagatgctg gcagttgtgg aaactatcaa
      781 tgcagcaatt ggagtcacta cgtcaccggt gctgccttct ctgatccagc ttcttggaag
      841 aaattttatt ttgtttatca tctttggcac catggaagaa atgcagaaca aagctgtggt
      901 tttctttgtg ttttatttgt ggagtgcaat tgaaattttc aggtactctt tctacatgct
      961 gacgtgcatt gacatggatt ggaaggtgct cacatggctt cgttacactc tgtggattcc
     1021 cttatatcca ctgggatgtt tggcggaagc tgtctcagtg attcagtcca ttccaatatt
     1081 caatgagacc ggacgattca gtttcacatt gccatatcca gtgaaaatca aagttagatt
     1141 ttcctttttt cttcagattt atcttataat gatattttta ggtttataca taaattttcg
     1201 tcacctttat aaacagcgca gacggcgcta tggacaaaaa aagaaaaaga tccactaaaa
     1261 agaaagattt agatggcttc ttgccagttt gagcctaatc tgattcttac agttttacct
     1321 tcttgaacca atgtaaaagt ttttttaatg ttaaatgatt aaattctcag tgaggctatc
     1381 ttccttttcc ccagtaacat tcctgaattt actgttatct tattgtagta cttgcatgac
     1441 atggattcct gatatctgat gagaggttca ttcttgtgta ttcagttaat gacaccaaaa
     1501 ggctcagccc accccaaccc tatctcatgt tcagtctgtc taatacatgc cagagatttt
     1561 tttttcaaaa agtgctttat ccctacaatg tactgacagt tcttacagtt gagatttgtt
     1621 cttttcagct attgcttgtg aaaaaaagca agactatgtc actctataga aggctgttaa
     1681 agtgactcag gcaggaatta attattctgt acctaagggg ttacttgttt aatgggatgg
     1741 cattgacttt ttgaaaatca agtggactga gtcattgata aaacatttct aagagtgggg
     1801 ctagagaaca tactttacat ctgacatcct ttggcctaac aacatctatt attatagtgc
     1861 tcagcagtgt gggcattgaa gaggcgcaga atgctttgaa agaaactaat cagaatcttg
     1921 gaacatcatg atcatgccat tcttaagtaa atcaactatt ttcaacactg aagaaaaatg
     1981 aaacattatt tagaaaacaa tgagattaca agttccaaac tcagccagga atgtggctca
     2041 cacctgtaat cccagcactt tgggacacct aggtgggagc atcgcttgaa gccaggagtt
     2101 caagaccagc ttgggcaacg tagtgagacc cctatctcta caaaaaataa aaaaattagc
     2161 tgggtgtgat ggcacacacc tgttgtccca gctactcaag aagctgagat gggaggatcc
     2221 tgagctcagg aggtcaaggc tgcagtgagc cgagattgtg ccactgcact gcagctgggg
     2281 tgacagtgca agaccctgtc tcaaaccaaa ccaaaccaca cacacacaaa cacacataca
     2341 cacacacaca cacgaggtcc aaatggtagc agggatccaa agggaacaca gtatgtaggt
     2401 caaactggca gtaacagtgt acagcctttg acaaactaga aatattagag taggccaaac
     2461 acacctccaa actgtaaggc tgtgcacaaa cataaaaaat ggcagccttc catctcctgc
     2521 actggctgag tccatttact tgtgtacttg ttctagtgag tggtgggact gtacattttt
     2581 gaatagacct caaaaatact tcattctgct gctgttcagt tggcttttta aacctgtctg
     2641 cagtaggaca ctgaaaacag caagaacttc ggggtgaaca cccgctgatc ctttaacaag
     2701 gatttctggc aggaaactca caaaaaggag aactgaaaat ttagacatac agttggccat
     2761 tgtaaaaaac atcagtttcc tctcatacat tccaagtaaa ccaagtaaaa taagtgttgg
     2821 agtaacactt gcataaaaga atttaaggag tgatagctct ttctgttctg ccattcccaa
     2881 cattcctggg ggaaaggaga ctcaatgagt taatactatt tcactgagcc caagatggaa
     2941 acttggtttg acctaaaaca tctgattaat ataggctagc tgatttctta aaaattcgtt
     3001 gcattgaagg atattttgca tgtctgtaac acctgtcaat acttgtttgt attgatttct
     3061 gatattcttg cagctgacta cgtgtaattg ggcagatcag ctttgcagta gattatgctg
     3121 catcctcgtg gcaaaattct gtattcttag tgattgttac aaaccccttt attgctgtct
     3181 gagaaagtga aagattgtgt atttctatta aaacatttac aatcaaaa
//
