LOCUS       NM_014282               2651 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens hyaluronan binding protein 4 (HABP4), mRNA.
ACCESSION   NM_014282
VERSION     NM_014282.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Saito,A., Souza,E.E., Costa,F.C., Meirelles,G.V., Goncalves,K.A.,
            Santos,M.T., Bressan,G.C., McComb,M.E., Costello,C.E., Whelan,S.A.
            and Kobarg,J.
  TITLE     Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and
            Affects PML Nuclear Body Formation
  JOURNAL   J Proteome Res 16 (9), 3147-3157 (2017)
   PUBMED   28695742
  REMARK    GeneRIF: Ki-1-57 is a target of sumoylation and affects pml nuclear
            body formation.
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Goncalves Kde,A., Bressan,G.C., Saito,A., Morello,L.G.,
            Zanchin,N.I. and Kobarg,J.
  TITLE     Evidence for the association of the human regulatory protein
            Ki-1/57 with the translational machinery
  JOURNAL   FEBS Lett 585 (16), 2556-2560 (2011)
   PUBMED   21771594
  REMARK    GeneRIF: Ki-1/57 may be involved in translational regulation
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Gray-McGuire,C., Guda,K., Adrianto,I., Lin,C.P., Natale,L.,
            Potter,J.D., Newcomb,P., Poole,E.M., Ulrich,C.M., Lindor,N.,
            Goode,E.L., Fridley,B.L., Jenkins,R., Le Marchand,L., Casey,G.,
            Haile,R., Hopper,J., Jenkins,M., Young,J., Buchanan,D.,
            Gallinger,S., Adams,M., Lewis,S., Willis,J., Elston,R.,
            Markowitz,S.D. and Wiesner,G.L.
  TITLE     Confirmation of linkage to and localization of familial colon
            cancer risk haplotype on chromosome 9q22
  JOURNAL   Cancer Res 70 (13), 5409-5418 (2010)
   PUBMED   20551049
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Bressan,G.C. and Kobarg,J.
  TITLE     From protein interaction profile to functional assignment: the
            human protein Ki-1/57 is associated with pre-mRNA splicing events
  JOURNAL   RNA Biol 7 (3), 268-271 (2010)
   PUBMED   20436279
  REMARK    GeneRIF: Ki-1/57 is localized to several subnuclear domains, all of
            which have been described to splicing and other RNA processing
            events.
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Bressan,G.C., Quaresma,A.J., Moraes,E.C., Manfiolli,A.O.,
            Passos,D.O., Gomes,M.D. and Kobarg,J.
  TITLE     Functional association of human Ki-1/57 with pre-mRNA splicing
            events
  JOURNAL   FEBS J 276 (14), 3770-3783 (2009)
   PUBMED   19523114
  REMARK    GeneRIF: Findings suggest that Ki-1/57 is probably involved in
            cellular events related to RNA functions, such as pre-mRNA
            splicing.
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Lemos,T.A., Passos,D.O., Nery,F.C. and Kobarg,J.
  TITLE     Characterization of a new family of proteins that interact with the
            C-terminal region of the chromatin-remodeling factor CHD-3
  JOURNAL   FEBS Lett 533 (1-3), 14-20 (2003)
   PUBMED   12505151
  REMARK    GeneRIF: interacts with the C-terminal region of the human
            chromatin-remodeling factor CHD-3
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Huang,L., Grammatikakis,N., Yoneda,M., Banerjee,S.D. and Toole,B.P.
  TITLE     Molecular characterization of a novel intracellular
            hyaluronan-binding protein
  JOURNAL   J Biol Chem 275 (38), 29829-29839 (2000)
   PUBMED   10887182
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Kobarg,J., Schnittger,S., Fonatsch,C., Lemke,H., Bowen,M.A.,
            Buck,F. and Hansen,H.P.
  TITLE     Characterization, mapping and partial cDNA sequence of the 57-kD
            intracellular Ki-1 antigen
  JOURNAL   Exp Clin Immunogenet 14 (4), 273-280 (1997)
   PUBMED   9523163
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Rohde,D., Hansen,H., Hafner,M., Lange,H., Mielke,V., Hansmann,M.L.
            and Lemke,H.
  TITLE     Cellular localizations and processing of the two molecular forms of
            the Hodgkin-associated Ki-1 (CD30) antigen. The protein kinase
            Ki-1/57 occurs in the nucleus
  JOURNAL   Am J Pathol 140 (2), 473-482 (1992)
   PUBMED   1310832
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR006985.1, AF241831.1, BC018788.1, CN287447.1 and AK025144.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014282.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.137661.1,
                                           SRR1660807.226614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375249.5/ ENSP00000364398.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               DR006985.1         16-438
            424-1272            AF241831.1         388-1236
            1273-1820           BC018788.1         926-1473
            1821-2547           CN287447.1         6-732               c
            2548-2651           AK025144.1         1909-2012
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..2651
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /note="hyaluronan binding protein 4"
                     /db_xref="GeneID:22927"
                     /db_xref="HGNC:HGNC:17062"
                     /db_xref="MIM:617369"
     exon            1..460
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1353
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /note="chromodomain helicase DNA binding protein 3
                     interacting protein; intracellular antigen detected by
                     monoclonal antibody Ki-1; ki-1/57 intracellular antigen"
                     /codon_start=1
                     /product="intracellular hyaluronan-binding protein 4"
                     /protein_id="NP_055097.2"
                     /db_xref="CCDS:CCDS6719.1"
                     /db_xref="GeneID:22927"
                     /db_xref="HGNC:HGNC:17062"
                     /db_xref="MIM:617369"
                     /translation="MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILRE
                     AERRRQQQLQRKRRDEAAAAAGAGPRGGRSPAGASGHRAGAGGRRESQKERKSLPAPV
                     AQRPDSPGGGLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQA
                     DFTAEKFPDEKPGDRFDRDRPLRGRGGPRGGMRGRGRGGPGNRVFDAFDQRGKREFER
                     YGGNDKIAVRTEDNMGGCGVRTWGSGKDTSDVEPTAPMEEPTVVEESQGTPEEESPAK
                     VPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPSKAVVIHKSKYRDDM
                     VKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRA
                     EVVMQDVAPNPDDPEDFPALS"
     exon            461..623
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            624..785
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            786..854
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            855..938
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1110
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1296
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2651
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /note="hexamer: ATTAAA"
     polyA_site      1820
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /note="major polyA site"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
                     /note="hexamer: AATAAA"
     polyA_site      2651
                     /gene="HABP4"
                     /gene_synonym="IHABP-4; IHABP4; Ki-1/57; SERBP1L"
ORIGIN      
        1 agggcccgga gggcggtggc ggcggagcgg gcggcatggg tcctggccgc cggcttcgct
       61 gagacgcgct cgcgtgggct gccctcccgg gcccgcagtg gtcgcggcgg catgaagggc
      121 gctctgggga gtcccgtggc tgccgctggc gccgcgatgc aggagagttt cggctgcgtg
      181 gtggccaacc gcttccatca gctgctggac gacgagtcgg acccgttcga catcctgcgc
      241 gaggccgagc gccggcgcca gcagcagctg cagcgcaaga ggcgcgacga ggcggcggcg
      301 gcggccgggg ccggtccccg cggcggcagg agcccagccg gggcctcggg ccacagagcc
      361 ggcgcgggcg gccggaggga gtcgcagaag gagcgcaaga gcctcccggc gcccgtcgct
      421 cagcggcccg atagccccgg gggcggcctg caggcgccgg gccagaagcg gactcctaga
      481 agaggggagc agcaaggatg gaatgacagc cgtgggccgg aggggatgct cgaaagagct
      541 gagcggagat cctacaggga ataccgaccc tatgagacag agaggcaggc agacttcaca
      601 gctgagaagt ttccagatga aaaaccaggt gataggtttg atcgagacag accgttgaga
      661 ggacgtggag gcccgagagg gggtatgcgc ggcagaggca gaggtggccc tgggaacaga
      721 gtttttgacg cttttgacca gagaggaaag cgagaatttg aaagatatgg tgggaatgac
      781 aaaatagcag tcagaactga agacaacatg ggtggatgtg gagttcgaac ctggggatcg
      841 ggtaaagata ccagtgatgt ggagccaact gcaccgatgg aggaacccac agtggtggag
      901 gagtcccagg gcaccccgga agaggagtct ccagccaaag ttcctgagtt ggaggtagaa
      961 gaagaaaccc aagttcaaga gatgacttta gatgagtgga aaaatcttca agaacagacc
     1021 agaccaaagc ctgagtttaa catccggaaa ccagaatcca ctgttccttc caaagccgtg
     1081 gtgattcaca agtcaaaata cagagatgat atggtaaaag atgactatga ggacgattcc
     1141 catgttttcc ggaaacccgc caatgacatc acatcccagc tggagattaa ttttggtaac
     1201 ctccctcgtc ctgggcgtgg agccagagga ggcacccggg gaggccgggg aaggatcagg
     1261 agggcagaga actatggacc cagagcagaa gtggtgatgc aagatgttgc ccccaaccca
     1321 gatgacccgg aagatttccc tgcgctgtct tgaaagagcc ctgtttccca gcaccgcgga
     1381 gctgcactgc acacctgtgg ggagactttt ccagctgggc caagggagtc agactctaag
     1441 aacaatagat gttgcttttc ccgtgtcatg taaatttgtt gcactttttt gggctgagct
     1501 gttagagggg cttctccaga ggctcgagag caggccattt cccaagaaga tgaagaatgg
     1561 tgactgtgtt tttattgaag gaatttcaaa tgaagaataa tgtttaaaat gtgtatatag
     1621 agatagtata gactcctccg cggaagcatg gagggaaagg aggttgtaaa atagactcca
     1681 tggagactct taggaagcag tagattcccg ggggctgtgc ctttagcgtt agaggaaaca
     1741 catagagctg gaactgttaa tggaaagcag tcacagctga gttttcggag accaagaaat
     1801 taaaatacaa ttgcacttac tgtttacttg taaatgttat cttctctcct ggaatatttt
     1861 gagttctggt tttcacttaa ccaatcattt aaaaatcgct attgtgtagc cactggccac
     1921 cactctgtga cacagaatca gagaaagcgt tgatttttaa tggtgattta aactacctcg
     1981 tggtttctgt gtgtgtgcac acacacatct agtgtttggg tggtttttag gaagaatatt
     2041 aagtatgtga cttcaaaaac catgttattt aacctgccaa tcaaatggaa agggatcatg
     2101 gcaaaagcaa ataccgcatc cttttcttcc gcagaactag agtcagagtt cggcagctgc
     2161 gtacaaaggc ctctgccctc ggcttgagca aaagttgtaa ataactagta tttattaagc
     2221 acttataagc agtttttctc acttagtcct ggctccagtt ctagagttcc tctttattgc
     2281 ttttggtgaa agtttggggt tgggggtaca cctcagaggt tcagtaattc acctggagtc
     2341 ccaccctgaa cagagctgga cccagagcca cacacgcccg ggaacacaca ctgtgctggg
     2401 gaggaagtgg gcctaggagg gcctgcaggt ccaggcagct gtagagctgc tagaagctgg
     2461 ggtgttgctc tccccgcttt ctcatagaca cagaggtact gtctgcctgt tgtcacacag
     2521 ttcatatgct cgcttgagat ggaatctgaa ccttggtccc aggatctgtg ctttttccca
     2581 ctttgccaca ctgtctaagg tggctttgaa ctggaaccca agtgcaaata aaggttggta
     2641 ttcgctcctg a
//
