LOCUS       NM_004132               2985 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hyaluronan binding protein 2 (HABP2), transcript
            variant 1, mRNA.
ACCESSION   NM_004132
VERSION     NM_004132.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Etscheid,M., Hanschmann,K.M., Sandset,P.M. and Kanse,S.M.
  TITLE     Development of a Factor VII Activating Protease (FSAP) generation
            assay and its application in studying FSAP in venous thrombosis
  JOURNAL   Thromb Res 220, 24-34 (2022)
   PUBMED   36265411
  REMARK    GeneRIF: Development of a Factor VII Activating Protease (FSAP)
            generation assay and its application in studying FSAP in venous
            thrombosis.
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Cui,X.Y., Stavik,B., Thiede,B., Sandset,P.M. and Kanse,S.M.
  TITLE     FSAP Protects against Histone-Mediated Increase in Endothelial
            Permeability In Vitro
  JOURNAL   Int J Mol Sci 23 (22), 13706 (2022)
   PUBMED   36430180
  REMARK    GeneRIF: FSAP Protects against Histone-Mediated Increase in
            Endothelial Permeability In Vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2985)
  AUTHORS   Gramstad,O.R., Kandanur,S.P.S., Etscheid,M., Nielsen,E.W. and
            Kanse,S.M.
  TITLE     Factor VII activating protease (FSAP) is not essential in the
            pathophysiology of angioedema in patients with C1 inhibitor
            deficiency
  JOURNAL   Mol Immunol 142, 95-104 (2022)
   PUBMED   34973499
  REMARK    GeneRIF: Factor VII activating protease (FSAP) is not essential in
            the pathophysiology of angioedema in patients with C1 inhibitor
            deficiency.
REFERENCE   4  (bases 1 to 2985)
  AUTHORS   Tian,D.S., Qin,C., Zhou,L.Q., Yang,S., Chen,M., Xiao,J., Shang,K.,
            Bosco,D.B., Wu,L.J. and Wang,W.
  TITLE     FSAP aggravated endothelial dysfunction and neurological deficits
            in acute ischemic stroke due to large vessel occlusion
  JOURNAL   Signal Transduct Target Ther 7 (1), 6 (2022)
   PUBMED   34992208
  REMARK    GeneRIF: FSAP aggravated endothelial dysfunction and neurological
            deficits in acute ischemic stroke due to large vessel occlusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2985)
  AUTHORS   Martinez-Palacian,A., Kanse,S.M. and Weiskirchen,R.
  TITLE     Factor VII activating protease (FSAP): a novel protective factor in
            liver fibrosis
  JOURNAL   Proteomics Clin Appl 8 (5-6), 438-446 (2014)
   PUBMED   24497464
  REMARK    GeneRIF: FSAP functions in initiation and progression of hepatic
            fibrosis
            Review article
REFERENCE   6  (bases 1 to 2985)
  AUTHORS   Choi-Miura,N.H., Takahashi,K., Yoda,M., Saito,K., Mazda,T. and
            Tomita,M.
  TITLE     Proteolytic activation and inactivation of the serine protease
            activity of plasma hyaluronan binding protein
  JOURNAL   Biol Pharm Bull 24 (5), 448-452 (2001)
   PUBMED   11379758
REFERENCE   7  (bases 1 to 2985)
  AUTHORS   Choi-Miura,N.H., Yoda,M., Saito,K., Takahashi,K. and Tomita,M.
  TITLE     Identification of the substrates for plasma hyaluronan binding
            protein
  JOURNAL   Biol Pharm Bull 24 (2), 140-143 (2001)
   PUBMED   11217080
REFERENCE   8  (bases 1 to 2985)
  AUTHORS   Sumiya,J., Asakawa,S., Tobe,T., Hashimoto,K., Saguchi,K.,
            Choi-Miura,N.H., Shimizu,Y., Minoshima,S., Shimizu,N. and Tomita,M.
  TITLE     Isolation and characterization of the plasma hyaluronan-binding
            protein (PHBP) gene (HABP2)
  JOURNAL   J Biochem 122 (5), 983-990 (1997)
   PUBMED   9443814
REFERENCE   9  (bases 1 to 2985)
  AUTHORS   Choi-Miura,N.H., Tobe,T., Sumiya,J., Nakano,Y., Sano,Y., Mazda,T.
            and Tomita,M.
  TITLE     Purification and characterization of a novel hyaluronan-binding
            protein (PHBP) from human plasma: it has three EGF, a kringle and a
            serine protease domain, similar to hepatocyte growth factor
            activator
  JOURNAL   J Biochem 119 (6), 1157-1165 (1996)
   PUBMED   8827452
REFERENCE   10 (bases 1 to 2985)
  AUTHORS   Gupta,S., Batchu,R.B. and Datta,K.
  TITLE     Purification, partial characterization of rat kidney hyaluronic
            acid binding protein and its localization on the cell surface
  JOURNAL   Eur J Cell Biol 56 (1), 58-67 (1991)
   PUBMED   1724753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC413026.1, D49742.1,
            AL390197.19, AA484932.1 and AI373912.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004132.4.
            
            Summary: This gene encodes a member of the peptidase S1 family of
            serine proteases. The encoded preproprotein is secreted by
            hepatocytes and proteolytically processed to generate heavy and
            light chains that form the mature heterodimer. Further
            autoproteolysis leads to smaller, inactive peptides. This
            extracellular protease binds hyaluronic acid and may play a role in
            the coagulation and fibrinolysis systems. Mutations in this gene
            are associated with nonmedullary thyroid cancer and susceptibility
            to venous thromboembolism. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49742.1, S83182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351270.4/ ENSP00000277903.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               DC413026.1         35-578
            545-2350            D49742.1           572-2377
            2351-2351           AL390197.19        103245-103245
            2352-2847           D49742.1           2378-2873
            2848-2873           AA484932.1         265-290
            2874-2985           AI373912.1         10-121              c
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..2985
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /note="hyaluronan binding protein 2"
                     /db_xref="GeneID:3026"
                     /db_xref="HGNC:HGNC:4798"
                     /db_xref="MIM:603924"
     exon            1..138
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1752
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /EC_number="3.4.21.92"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; factor VII activating protein; hyaluronic acid
                     binding protein 2; hepatocyte growth factor activator-like
                     protein; plasma hyaluronan binding protein; factor
                     VII-activating protease; factor seven-activating protease"
                     /codon_start=1
                     /product="hyaluronan-binding protein 2 isoform 1
                     preproprotein"
                     /protein_id="NP_004123.1"
                     /db_xref="CCDS:CCDS7577.1"
                     /db_xref="GeneID:3026"
                     /db_xref="HGNC:HGNC:4798"
                     /db_xref="MIM:603924"
                     /translation="MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDY
                     SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAP
                     FSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQ
                     NGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYW
                     NSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSAC
                     SAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSS
                     LPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRV
                     EKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHIS
                     GWGVTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGD
                     SGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF"
     exon            139..175
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            176..292
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            293..400
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            401..517
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            518..637
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            638..809
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            810..907
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1163
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1306
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1441
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1587
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..2985
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /note="hexamer: AATAAA"
     polyA_site      2985
                     /gene="HABP2"
                     /gene_synonym="FSAP; HABP; HGFAL; NMTC5; PHBP"
                     /note="major polyA site"
ORIGIN      
        1 cccccctaaa ggcatagaca acaaaagaaa ttttattgag aggaaaacac aagtccttaa
       61 actgcaaaga tgtttgccag gatgtctgat ctccatgttc tgctgttaat ggctctggtg
      121 ggaaagacag cctgtgggtt ctccctgatg tctttattgg aaagcctgga cccagactgg
      181 acccctgacc agtatgatta cagctacgag gattataatc aggaagagaa caccagtagc
      241 acacttaccc acgctgagaa tcctgactgg tactacactg aggaccaagc tgatccatgc
      301 cagcccaacc cctgtgaaca cggtggggac tgcctcgtcc atgggagcac cttcacatgc
      361 agctgcctgg ctcctttctc tgggaataag tgtcagaaag tgcaaaatac gtgcaaggac
      421 aacccatgtg gccggggcca atgtctcatt acccagagtc ctccctacta ccgctgtgtc
      481 tgtaaacacc cttacacagg tcccagctgc tcccaagtgg ttcctgtatg caggccaaac
      541 ccctgccaga atggggctac ctgctcccgg cataagcgga gatccaagtt cacctgtgcc
      601 tgtcccgacc agttcaaggg gaaattctgt gaaataggtt ctgatgactg ctatgttggc
      661 gatggctact cttaccgagg gaaaatgaat aggacagtca accagcatgc gtgcctttac
      721 tggaactccc acctcctctt gcaggagaat tacaacatgt ttatggagga tgctgaaacc
      781 catgggattg gggaacacaa tttctgcaga aacccagatg cggacgaaaa gccctggtgc
      841 tttattaaag ttaccaatga caaggtgaaa tgggaatact gtgatgtctc agcctgctca
      901 gcccaggacg ttgcctaccc agaggaaagc cccactgagc catcaaccaa gcttccgggg
      961 tttgactcct gtggaaagac tgagatagca gagaggaaga tcaagagaat ctatggaggc
     1021 tttaagagca cggcgggcaa gcacccatgg caggcgtccc tccagtcctc gctgcctctg
     1081 accatctcca tgccccaggg ccacttctgt ggtggggcgc tgatccaccc ctgctgggtg
     1141 ctcactgctg cccactgcac cgacataaaa accagacatc taaaggtggt gctaggggac
     1201 caggacctga agaaagaaga atttcatgag cagagcttta gggtggagaa gatattcaag
     1261 tacagccact acaatgaaag agatgagatt ccccacaatg atattgcatt gctcaagtta
     1321 aagccagtgg atggtcactg tgctctagaa tccaaatacg tgaagactgt gtgcttgcct
     1381 gatgggtcct ttccctctgg gagtgagtgc cacatctctg gctggggtgt tacagaaaca
     1441 ggaaaagggt cccgccagct cctggatgcc aaagtcaagc tgattgccaa cactttgtgc
     1501 aactcccgcc aactctatga ccacatgatt gatgacagta tgatctgtgc aggaaatctt
     1561 cagaaacctg ggcaagacac ctgccagggt gactctggag gccccctgac ctgtgagaag
     1621 gacggcacct actacgtcta tgggatagtg agctggggcc tggagtgtgg gaagaggcca
     1681 ggggtctaca cccaagttac caaattcctg aattggatca aagccaccat caaaagtgaa
     1741 agtggcttct aaggtactgt cttctggacc tcagagccca ctctccttgg caccctgaca
     1801 ccgggaggcc tcatggccaa caatggacac ctccagagcc tccaggggac cacacagtag
     1861 actatcccta ctctaagcag agacaactgc cacccagcct gggccttccc agaccagcat
     1921 ttgcacaata tcaccaggct tcttctgcct cccttggtaa cccaaggaat gatggaatca
     1981 acacaacata gtatgtttgc tttccttacc caattgtacc ttctagaaaa tcagtgttca
     2041 cagagactgc ctccaccaca ggcatcctgc aaatgcagac tccagaatcc ccagcatcag
     2101 cgggaaccac catcacatct ttattcctca gcccagacac tcgaggcact caacagaatc
     2161 agccatccac gtctaggtat cagagaggac cacaaataca acattctcca tctgctttca
     2221 gagttattat tttaataaag gaagatctgg gatgggctgg tgggccattc cagcttgccg
     2281 aaatcaaagc catctgaagc ctgtctctgg tgaacaaact tcctctctgg cctctcagga
     2341 atcagggtgg acatggctca caacagcagg gccttcttct ttttgacgtg cagaatctca
     2401 gtggcatctg ggttcacctc cccactctga tgatctccag cctccactgc ttctgccccc
     2461 cgctgctgaa atcaaacata ccccaagtta aaatgaagct cccccacccc cactcccggc
     2521 cccggttccc acaggacacg ctaagaagca cagggagcat ttaacaggct caccctccct
     2581 ttccttttcc cctcttctac cctccccaag aaaaagggcc ttcaaggcag gaatgagaaa
     2641 gcaaagccaa tctctcattt agacctggct tctttcttct gaacaaagta gggttcaaaa
     2701 tgcagactgt catatccagc gagtccctga ccctttctgc gaatgtaacg agcaagcagt
     2761 cagcacagcc tgggctgccc tggcccggga ttgatgtagc cccggtaggt ttgcctctgc
     2821 agaactaatg gctgtgactt cagagaaagc cctgcaggaa gtttaacctg cgtgtcatct
     2881 gcctggtcat ctcagaccca tgaaattagg cgccttgttt gagctgcgtt tcacacttct
     2941 ttagagctag ctgacctttg gccaaaaata aactttgaaa agaaa
//
