LOCUS       NM_004285               9147 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens hexose-6-phosphate dehydrogenase/glucose
            1-dehydrogenase (H6PD), transcript variant 2, mRNA.
ACCESSION   NM_004285
VERSION     NM_004285.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9147)
  AUTHORS   Ji,T., Gao,L. and Yu,Z.
  TITLE     Tumor-suppressive microRNA-551b-3p targets H6PD to inhibit
            gallbladder cancer progression
  JOURNAL   Cancer Gene Ther 28 (6), 693-705 (2021)
   PUBMED   33250514
  REMARK    GeneRIF: Tumor-suppressive microRNA-551b-3p targets H6PD to inhibit
            gallbladder cancer progression.
REFERENCE   2  (bases 1 to 9147)
  AUTHORS   Tsachaki,M., Mladenovic,N., Stambergova,H., Birk,J. and Odermatt,A.
  TITLE     Hexose-6-phosphate dehydrogenase controls cancer cell proliferation
            and migration through pleiotropic effects on the unfolded-protein
            response, calcium homeostasis, and redox balance
  JOURNAL   FASEB J 32 (5), 2690-2705 (2018)
   PUBMED   29295867
  REMARK    GeneRIF: Knockdown of H6PD resulted in an increase in ER lumen
            oxidation, and down-regulation of many components of the unfolded
            protein response, including the transcription factors activating
            transcription factor-4, activating transcription factor-6, split
            X-box binding protein-1, and CCAAT/enhancer binding protein
            homologous protein.
REFERENCE   3  (bases 1 to 9147)
  AUTHORS   Ranzani,A.T. and Cordeiro,A.T.
  TITLE     Mutations in the tetramer interface of human glucose-6-phosphate
            dehydrogenase reveals kinetic differences between oligomeric states
  JOURNAL   FEBS Lett 591 (9), 1278-1284 (2017)
   PUBMED   28370139
  REMARK    GeneRIF: Data indicate the tetramer as the most active form of
            glucose-6-phosphate dehydrogenase (G6PDH).
REFERENCE   4  (bases 1 to 9147)
  AUTHORS   Wang,Z., Mick,G.J., Xie,R., Wang,X., Xie,X., Li,G. and
            McCormick,K.L.
  TITLE     Cortisol promotes endoplasmic glucose production via pyridine
            nucleotide redox
  JOURNAL   J Endocrinol 229 (1), 25-36 (2016)
   PUBMED   26860459
  REMARK    GeneRIF: cortisol reduces glucose-6-phosphate (G6P) flux through
            H6PDH by increasing luminal NADPH, thereby allowing more G6P for
            hydrolysis via G6Pase
REFERENCE   5  (bases 1 to 9147)
  AUTHORS   Ju,R., Wu,W., Tang,Q., Wu,D., Xia,Y., Wu,J. and Wang,X.
  TITLE     Association Analysis between the Polymorphisms of HSD11B1 and H6PD
            and Risk of Polycystic Ovary Syndrome in Chinese Population
  JOURNAL   PLoS One 10 (10), e0140326 (2015)
   PUBMED   26452272
  REMARK    GeneRIF: The G allele of rs6688832 in H6PD might exert potential
            genetic protective role against the development of PCOS, especially
            in overweight women. PCOS patients with AG genotype of rs6688832
            might confer risk to the phenotype of hyperandrogenemia of PCOS.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9147)
  AUTHORS   Ikegwuonu,F.I. and Jefcoate,C.R.
  TITLE     Evidence for the involvement of the fatty acid and peroxisomal
            beta-oxidation pathways in the inhibition by dehydroepiandrosterone
            (DHEA) and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
            and benz(a)anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse
            embryo fibroblasts (C3H10T1/2 cells)
  JOURNAL   Mol Cell Biochem 198 (1-2), 89-100 (1999)
   PUBMED   10497882
REFERENCE   7  (bases 1 to 9147)
  AUTHORS   Mason,P.J., Stevens,D., Diez,A., Knight,S.W., Scopes,D.A. and
            Vulliamy,T.J.
  TITLE     Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
            encoded at 1p36: coding sequence and expression
  JOURNAL   Blood Cells Mol Dis 25 (1), 30-37 (1999)
   PUBMED   10349511
REFERENCE   8  (bases 1 to 9147)
  AUTHORS   Toncheva,D., Evrev,T. and Tzoneva,M.
  TITLE     G6PD in immature and mature human brain. Electrophoretic and enzyme
            kinetic studies
  JOURNAL   Hum Hered 32 (3), 193-196 (1982)
   PUBMED   7106784
REFERENCE   9  (bases 1 to 9147)
  AUTHORS   Tan,S.G. and Ashton,G.C.
  TITLE     An autosomal glucose-6-phosphate dehydrogenase (hexose-6-phosphate
            dehydrogenase) polymorphism in human saliva
  JOURNAL   Hum Hered 26 (2), 113-123 (1976)
   PUBMED   950237
REFERENCE   10 (bases 1 to 9147)
  AUTHORS   Beutler,E. and Morrison,M.
  TITLE     Localization and characteristics of hexose 6-phosphate
            dehydrogenase (glucose dehydrogenase)
  JOURNAL   J Biol Chem 242 (22), 5289-5293 (1967)
   PUBMED   4169027
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98044.13, BC081559.1 and
            AJ012590.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004285.3.
            
            Summary: There are 2 forms of glucose-6-phosphate dehydrogenase. G
            form is X-linked and H form, encoded by this gene, is autosomally
            linked. This H form shows activity with other hexose-6-phosphates,
            especially galactose-6-phosphate, whereas the G form is specific
            for glucose-6-phosphate. Both forms are present in most tissues,
            but H form is not found in red cells. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) uses an alternate 5' most exon
            compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2459087.1,
                                           SRR1803613.46363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377403.7/ ENSP00000366620.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                Z98044.13          46822-46851         c
            31-70               BC081559.1         31-70
            71-1318             AJ012590.1         40-1287
            1319-1660           BC081559.1         1319-1660
            1661-9147           Z98044.13          10288-17774         c
FEATURES             Location/Qualifiers
     source          1..9147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..9147
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /note="hexose-6-phosphate dehydrogenase/glucose
                     1-dehydrogenase"
                     /db_xref="GeneID:9563"
                     /db_xref="HGNC:HGNC:4795"
                     /db_xref="MIM:138090"
     exon            1..293
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /inference="alignment:Splign:2.1.0"
     exon            294..930
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2679
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /EC_number="1.1.1.47"
                     /EC_number="3.1.1.31"
                     /EC_number="1.1.1.363"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; GDH/6PGL endoplasmic bifunctional protein;
                     glucose dehyrogenase; 6-phosphogluconolactonase;
                     glucose-6-phosphate dehydrogenase, salivary; G6PD, H form;
                     glucose dehydrogenase; glucose 1- dehydrogenase"
                     /codon_start=1
                     /product="GDH/6PGL endoplasmic bifunctional protein
                     isoform 2 precursor"
                     /protein_id="NP_004276.2"
                     /db_xref="CCDS:CCDS101.1"
                     /db_xref="GeneID:9563"
                     /db_xref="HGNC:HGNC:4795"
                     /db_xref="MIM:138090"
                     /translation="MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQ
                     GLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQF
                     LQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSC
                     RPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFR
                     DQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVA
                     MELPHNVSSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLT
                     PTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQ
                     CLPRQLVFHIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYS
                     PVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGGAENG
                     RLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISK
                     LANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCV
                     PLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVA
                     NSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAK
                     KVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG"
     exon            931..1048
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1318
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..9147
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9127..9132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /note="hexamer: AATAAA"
     polyA_site      9147
                     /gene="H6PD"
                     /gene_synonym="CORTRD1; G6PDH; GDH; H6PDH"
                     /note="major polyA site"
ORIGIN      
        1 agtcttgctg agcgcaaggc ggtggaggcc tgaggcctga ggcctggggc ggggtggcgg
       61 ccgggctggc cttggcctcg cgccttcccc tgcggccgcc gcgggctccg cgggcggtat
      121 cggagtgtcg tgcggcgcgt ggccgcgtga cacgcgcact tgtcggagtg acgggccctg
      181 cggaagagga ggtgcggccc agggcgcagg ggagccctcg ggagcgggcc cggccctcag
      241 cgccgccccg gccgtgtccc ggaggagcgg cctgcgccgc cgcgcgagag gaagcaccca
      301 ggcatgtgga atatgctcat agtggcgatg tgcttggccc ttctgggctg cctgcaagcc
      361 caggagctcc agggacatgt ctccataatc ctgctgggag caactgggga cctggctaag
      421 aagtacttat ggcagggact gttccagctg tacctggatg aagcggggag gggtcacagt
      481 tttagcttcc atggagctgc tctgacagcc cccaagcagg gtcaagagct catggccaag
      541 gccctggaat ccctctcctg ccccaaggac atggcaccca gtcactgtgc agagcacaag
      601 gatcagttcc tgcagctgag ccagtaccgc caactgaaga cggccgagga ctatcaggcc
      661 ctgaacaagg acatcgaggc acagctccag cacgcaggcc tccgggaggc tggcaggatc
      721 ttctacttct cagtgccacc cttcgcctat gaagacattg cccgcaacat caacagtagc
      781 tgccggccag gcccgggcgc ctggctgcgg gttgtccttg agaaaccctt tggccatgac
      841 cacttctcag cccagcagct ggccacagaa ctcgggacct ttttccagga ggaggagatg
      901 taccgggtgg accattactt aggcaagcag gctgtggcgc agatcctgcc tttccgagac
      961 cagaaccgca aggctttgga cggcctctgg aaccggcacc atgtggagcg ggtggagatc
     1021 atcatgaaag agaccgtgga tgctgaaggc cgcaccagct tctatgagga gtacggtgtc
     1081 attcgcgacg tcctccagaa ccatctgacg gaggtcctca ccctcgtggc catggagctg
     1141 ccccacaatg tcagcagtgc ggaggctgtg ctgcggcaca agcttcaggt cttccaggcg
     1201 ctgcggggcc tgcagagggg cagtgccgtc gtgggccagt accagtctta cagtgagcag
     1261 gtgcgcagag agctgcagaa gccagacagc ttccacagcc tgacgccgac cttcgcagcc
     1321 gtcctagtgc acattgacaa ccttcgctgg gagggcgtgc ctttcatcct gatgtctggc
     1381 aaagccttgg acgagagagt gggctacgct cggatcttgt tcaagaacca ggcctgctgt
     1441 gtgcagagcg aaaagcactg ggccgcggcg cagagccagt gcctgccccg gcagctcgtc
     1501 ttccacatcg gccatggcga cctgggcagc cctgccgtgc tggtcagcag gaacctgttc
     1561 aggccctccc tgccctccag ctggaaggaa atggagggac cacctgggct ccgccttttc
     1621 ggcagccctc tgtccgatta ctacgcctac agccctgtgc gggagcggga cgcccactcc
     1681 gtcctcttat cccatatctt ccatggccgg aagaatttct tcatcaccac agagaacttg
     1741 ctggcctcct ggaacttctg gacccctctg ctggagagcc tggcccataa ggccccacgc
     1801 ctctaccctg gaggagctga gaatggccgt ctgttggact ttgagttcag tagcggccgg
     1861 ttgttctttt cccagcagca gccggagcag ctggtgccag ggccagggcc ggccccaatg
     1921 cccagtgact tccaggtcct cagggccaag taccgagaga gcccgctggt ctccgcctgg
     1981 tccgaggagc tgatctctaa gctggctaat gacatcgagg ccaccgctgt gcgagccgtg
     2041 cggcgctttg gccagttcca cctggcactg tcggggggct cgagccccgt ggccctgttc
     2101 cagcagctgg ccacggcgca ctatggcttc ccctgggccc acacgcacct gtggctggtt
     2161 gacgagcgct gcgtcccact ctcagacccg gagtccaact tccagggcct gcaggcccac
     2221 ctgctgcagc acgtccggat cccctactac aacatccacc ccatgcctgt gcacctgcag
     2281 cagcggctct gcgccgagga ggaccagggc gcccagatct atgccaggga gatctcagcc
     2341 ctggtggcca acagcagctt cgacctggtg ctgctgggca tgggtgccga cgggcacaca
     2401 gcctccctct tcccacagtc acccactggc ctggatggcg agcagctggt cgtgctgacc
     2461 acgagcccct cccagccaca ccgccgcatg agccttagcc tgcctctcat caaccgcgcc
     2521 aagaaggtgg cagtcctggt catgggcagg atgaagcgtg agatcaccac gctggtgagc
     2581 cgggtgggcc atgagcccaa gaagtggccc atctcgggtg tcctgccgca ctccggccag
     2641 ctggtgtggt acatggacta cgacgccttc ctgggatgag ggcgcctgtg ccccttgccc
     2701 gcttcgctcc tgtgctttcc ttcgcccgtg tcttccctcc cttctcggcc ccgccacctg
     2761 cccagcgtgc cctggctctc cagaaccttc tatcccacag tcaggcccca gagagggcag
     2821 gacaagcctt gtcccgatgc ctttgaccgg cagctctgtg tattggtgga tagatgcaga
     2881 aacaaggaag aaatggagtc tgctcctgag aagcttcaaa ttcaggccag gagagaagtc
     2941 ttaagaaaag acctccagca gttacacatt catatcaacc agcacaacac gggatggcgc
     3001 ccaaactccg gcgttcacaa gaggagacgt gacgtggtgg gctgaggtta atcagggaag
     3061 gtttcctggg ggaggtgatc cttgaactgg ctcccgggga acattcagag catgattggt
     3121 agacagaagg gtgcagaggc gcccagggga gtacattgcc ccgtgcaaag caggggcatt
     3181 ggggactgtc ttgagaccct gagggggtca agcccctcct tccccagctg cccctccttc
     3241 tagaacctct gcacatctag cctctggccc tcctcttcac tgcctccacc tgctcccgct
     3301 tgccatccct gtctcctcca tcctggctgt gcagtaggaa ttccaggctc ctccctgtgt
     3361 ctttgctgtt cttcagactc catttataga gaatgagggc tgataacagg aatacagtgg
     3421 caaagactag actgtggaaa gggttccaga aatctttttt cttttttaat taaaaaaaat
     3481 atttgcagag atgagctctt gctatgttgc ccaggctggt ctcaaactcc tgggctcaag
     3541 cgatcctccc atctcagcct cccagagtgc tgggattaca ggtgtgagct actgcgccca
     3601 gccccagaaa tctcagtgct gtttggagct ccatttctca tttgatgact tgctctgcgt
     3661 ggggaggtgg ggtctcattc ccccaacttc ctcagggagg acccctgccc tccgctgctc
     3721 ctctgtcctg ctagccttcc tccaggaagc acactgggtg cagataatca ggacattcca
     3781 gagatcccca atttaagagg gtcatttcca tctcagggga ctcccggatg ggtgtttccg
     3841 ctctcaatag cccctcttgt tttaccagga aagatccagt taaatcaccc actgaggtga
     3901 cagctcatta gcggggagag agatggagca tcgagtgaca ctgggccatc caggcggctc
     3961 tgctcccacc agacaggagc taggcctcac tggcaggggg gctgcccaca gccttttcag
     4021 gggctcgctt ggcgggtgac ggggccgcag ccaggccttc tctccctgcc ccttggtgac
     4081 cccgtggctt cctgtctgct ggcctctcct gctacttatc acttcaccac gaactctctg
     4141 cctgagactg gggaagtaag cgggtatctt ctcagtgagc ataggttggg gactgtgatc
     4201 ttgagaagcc atgggccagc aatacctgct tttctgaagc ccccaaggag ggctctgaca
     4261 ttctttttaa aaacaccaca aagcaaaatt cccaggacat gtgtagtttt gtttgttcag
     4321 tatcccacaa cttaaggctg ggagatggaa ctcttggtta aggtcgattt ttctgtctgg
     4381 cttctccgca ccttccactt gctctctgga tcaggcagat ataaactttc tagcgcattt
     4441 tgagagaggg ctttcttggg tgagggagca tggcaaagtc ggtttctctc tggactgttt
     4501 acacttcaag gcggtggatt tagaggaatc ctggctttca ttttcaatgc cagtctgaga
     4561 catgttccca agccggggct cttgttcaca ccacttactc tggccaccaa caacaaccca
     4621 ggccagacag agcatctctt tttttttttt ttgagacaga gtctctgtcg cccaggctgg
     4681 agcccagtgg cgagatcttg gctcactaca acctccacct cccgggttca ggcaattctc
     4741 gtgcctaagc ctcccgagta gctgcgacta caggcgccgg ccagcatgcc tgtctaattt
     4801 ttgtatttta gtagagacag ggtttcacca tgttgcccag gctggtctcg aactcctgag
     4861 ctcaggcagt ctacccacct cagcctccca aagtgctggg attacaggcg tgagccaccg
     4921 cgcccagcca gaacatctgt ttttacaccc agagagcgcc cctcgttagg acagaaccac
     4981 ggtgcccaga gccaggaagc cgccctcctg gcgcccagca tctgagcttc tacacgtgat
     5041 gggcgggctc aggagaggac agggagtcgt ggtggaagtt ccacagctgg ccgcgtgggg
     5101 gggcccttgc accgcactgc cgcctcctga ctgcccctat ccccgcagcc cctgtgccgg
     5161 atttcatttc cctcctctct cccagggtac ctggccccag cactctccca tctgttcttc
     5221 aggaaccgac tcctctccag ttgcaacacc agggagaaag gggcctccac atgcccaagt
     5281 acccctgcag gatgaagggc aggccggccc ttgatgtgcc atttctgaat aatagtcact
     5341 gccgccgagt ctaggatgtc ctgttctaac tcagccctgc ctcggatgca ccaccgatct
     5401 gtgcagagtg ggtgtgggag tgtgggtgag ggtcgaaatg ccaaaggtct actttccaga
     5461 atcaagtgcc ttctgcaaat catgttggaa aagtccaaac ctggagatgt ccctgtgcct
     5521 ccgcccctac ccaccccttt tccttcagct gtgttaggaa ggagaagttt tcagaaccct
     5581 ctaggctggt ggctttcaaa cttcagacca tgatctgcag caagaaacgt gccttccatc
     5641 ataaatcagt ccatttgttt acaactgtgt tccaagcagg tttcataaag aaattcttaa
     5701 ccttagaacc tcggatatcc tctatgtttt agttttcatt tttttaaaat gcttcttaaa
     5761 attcactaaa ttgggctagg tgtggctcat gcctgtaatc ccagcactat gggaggctga
     5821 ggtgagagga tcacttgagc ccagaaggtt gaaaccagcc tgggcaacat agtgagaccc
     5881 catctctaca aaaagtttta aaaccaggta tggtggtgcc ctcctgtggt cccagctact
     5941 cgggagtctg aggtgggagg atcacctgag cccaggagac tgaggctgca gtaaggtgtg
     6001 attgcactat tgctctctag cctggaaaac agagtgagac cctatctcaa aaaaaaaaaa
     6061 aaaaaaaaag gaaagagtga tgacaacagc ccagggagca gccccgctca gaacccaagt
     6121 cccaagttcc agcactgtgt tcccaggcag gctgtttgcc tcttcctggt ctggaagccc
     6181 ttgggtccta tggtggcggc agctcccaca gtccaggttc cctggtgggg accaatgatt
     6241 ccatccgcat ggaagcccac gtgtgcactt aggggcccat aaatggcaga agggcccctc
     6301 ctttgggaga ccttgtcagt cagcatctct agggcaaccg tgattgccat ttgtagaggg
     6361 gaaggaatca agggacttta agctagatca aaatctgggg acaaattctc ctgctaactg
     6421 caagttaaaa taggcccttc ttactgaatt tccctgtttg tttctctgca gacaatgctt
     6481 tagccctact cttgggcccc caagttagca gagtaatcaa agcttcctac cgtttggcct
     6541 actattccag actagtccct cgaggggttc ccttccaaaa tatgcagggc tcaggctccc
     6601 aattccgggc ctgtctgctt tgcttgtgtt tctcctgtcc ctgttctccc ggagggccca
     6661 ggtggaactc acgacaggga gggagacgct tcccaaaaac ctgcagggct atttcccaga
     6721 atttggtttt caagtacaaa actttttgtc ctgtaagata tatgcagcct cacagaagca
     6781 gcctctgcct ccactttacc agctacgttt ttatcttaag cacatggggc tcccttagaa
     6841 cttactccac tgatttaaaa aaaaaaaact gcctggcagc atctcagtgt cagagtgagc
     6901 acggcacagg aaaggcccgt ggtgacgagg gtgaggtggc cacagtgacc ggacgacaaa
     6961 tgagactctg caaatgagac tccagagggt gaagatctgc ggtctccaga catcataggc
     7021 catgtgaccc actaggggcc gcttacccct ggccgtccgc tggctgaact gaacgcattc
     7081 cctctctccg caactctccc gtgaggctgc acccgtgtgg gtagcactgg aagcggcact
     7141 gtttgcattg tacataggaa ggaaggaagt tcttccagcc tcaccagcac ctggcagcga
     7201 gtcagagcct gtgagggcat ccgaagcagt gatgcagtgt caacctccca gctggtgcca
     7261 ctctgccctc gggggctcca agcattgtaa ctcagtcatg ggagctgcct ctttggaagt
     7321 gcagatttat tcctgtaata atcctgcctg cttttacctc tcgtccactg accagcaagt
     7381 gtgagtcccg gtgtcagtcg gcacagtcca gtgtccatct gcatttgctc atgcagaggg
     7441 ggtgagttgg gcactccctg ttgttggttt tccttttgca gcacactggg cagtctccct
     7501 ataaaacaaa aaccccacct tctgtgcctt ctgctttaga gcagagctcc ccctcccatt
     7561 tcctcagtct tccctgcaaa atctgtccac cggggaaggc agcaggaacc ctgggcagcg
     7621 ggtgttctgg gaaggctagt gacagcagat gtcatccagg aacagccaca cacggttctc
     7681 caggccgccg tcagcagctc aaggtggggt atgagtgaga agctgaggat ctcgcagctt
     7741 gttgctgagc aaggtgcaac cgggctcatg ctgtcatcag cacaagacgg gatggcaagg
     7801 gctttcagac gcatttccaa gagtccagca agccaggggg aagatgatcc ctttgccgaa
     7861 gtgtaccctc tagccaactt ttgggagcgc ttctgtttgc aaagcgctgg ggatgtgcct
     7921 gtctctgtgt gacccacgaa cgggaaggga gagcactgga gtaatgacac ttctgctgct
     7981 gctttgattc tcaaggctga tctttaaaac cctcgccttg ctgacaggtg ctttaaaggc
     8041 agtctgcatc ttttcttccc ttggtgtggg agaggtaaac actttgattt gctgaaagct
     8101 gtatggagta tatttgaaca gctagtagtt agctttgaaa gtggaagtgt gaacagacac
     8161 tacttgtgtc gctttgggtc cttcacttta cccccacaga agtctagagg cgtctgttat
     8221 aaagcgttac ggggcgcctg catgcaggag gaaggacctg tattagctgg aaatcatcag
     8281 gaacccagct tgcctccatc tctctgagat gtgctgggta cagcctgccc ctcctagttc
     8341 tgtccaccgg gaagagccgg ctggcggcag atccccaggg gcagagcccc tgctggatcc
     8401 tgggagctca tctttacctg tgccggagtg ggaactgtga ttccagccgg gcaggtcaga
     8461 gtggagcagt gctaagaggc tgttgcagga gaactagacg ggcggggcct gctgcatctg
     8521 gatcatgttt ctgtgctctg ccccgcgcta gggactcagg gtctgggctt ctgccaggtg
     8581 aggagcagag agactgttcc cttgggtgga gaggtgtggg catgagagcc acccattgcc
     8641 aagcagcaag aatgttcgtg cttttttcca gagaggggaa ccccactggt ttttgtggaa
     8701 acaatggaaa cttacagatg cctgcctggg atgatgaggc acattcagaa caaatgcttt
     8761 tttttttttg agacagagtc tcgctctgac gcccaggctg gagtgcagtg gcgcgatctc
     8821 ggctcactgc aaactttgcc tcccaggttc aagtgattct cctacctcag cctcccgagt
     8881 agctgggatt acaccaccat gcccagcaaa tttttgtgtt tttagtagag acggagtttc
     8941 accatgttgg ccaggctggt ctcgaactcc tgacctcagg tgatccatcc gccttggcct
     9001 cccaaagtgc tgggattaca ggcgggagcc accatgcctg gccagaacaa atgccttttt
     9061 aaacctttta agaacatttt taaaatgtct ttttctatgt caaatgtaac gtttattttt
     9121 ttaaacaata aaattgattt gccaaaa
//
