LOCUS       NM_003547                386 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H4 clustered histone 7 (H4C7), mRNA.
ACCESSION   NM_003547
VERSION     NM_003547.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 386)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 386)
  AUTHORS   Long,M., Sun,X., Shi,W., Yanru,A., Leung,S.T.C., Ding,D.,
            Cheema,M.S., MacPherson,N., Nelson,C.J., Ausio,J., Yan,Y. and
            Ishibashi,T.
  TITLE     A novel histone H4 variant H4G regulates rDNA transcription in
            breast cancer
  JOURNAL   Nucleic Acids Res 47 (16), 8399-8409 (2019)
   PUBMED   31219579
  REMARK    GeneRIF: A novel histone H4 variant H4G regulates ribosomal DNA
            transcription in breast cancer.
REFERENCE   4  (bases 1 to 386)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 386)
  AUTHORS   Lusic,M., Marcello,A., Cereseto,A. and Giacca,M.
  TITLE     Regulation of HIV-1 gene expression by histone acetylation and
            factor recruitment at the LTR promoter
  JOURNAL   EMBO J 22 (24), 6550-6561 (2003)
   PUBMED   14657027
REFERENCE   6  (bases 1 to 386)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 386)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 386)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 386)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 386)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003547.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC126276.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000611444.2/
                                             ENSP00000477870.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               AL031777.5         51993-52378         c
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..386
                     /gene="H4C7"
                     /gene_synonym="H4/l; H4FL; HIST1H4G"
                     /note="H4 clustered histone 7"
                     /db_xref="GeneID:8369"
                     /db_xref="HGNC:HGNC:4792"
                     /db_xref="MIM:602832"
     exon            1..386
                     /gene="H4C7"
                     /gene_synonym="H4/l; H4FL; HIST1H4G"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..316
                     /gene="H4C7"
                     /gene_synonym="H4/l; H4FL; HIST1H4G"
                     /note="H4 histone family, member L; histone 1, H4g;
                     histone cluster 1, H4g; histone cluster 1 H4 family member
                     g"
                     /codon_start=1
                     /product="histone H4-like protein type G"
                     /protein_id="NP_003538.1"
                     /db_xref="CCDS:CCDS4599.1"
                     /db_xref="GeneID:8369"
                     /db_xref="HGNC:HGNC:4792"
                     /db_xref="MIM:602832"
                     /translation="MSVRGKAGKGLGKGGAKCHRKVLSDNIQGITKCTIRRLARHGGV
                     KRILGLIYEETRRVFKVFLENVIWYAVTNTEHAKRKTVTAMAVVYVLKRQGRTL"
ORIGIN      
        1 tagttctgac ttgtttatca tgtctgttcg gggcaaggcc ggaaaaggcc ttgggaaagg
       61 cggtgccaag tgccatcgca aggtactgag cgataatatt cagggcatta ccaagtgcac
      121 tatccggcgc ttggcccggc atggcggtgt caagcgcatc ttgggcctca tttatgagga
      181 gacccgccgg gtgttcaagg tgttcctgga aaatgtgatc tggtacgccg tgaccaacac
      241 ggagcacgcc aagcgcaaga cggtcaccgc catggccgtg gtctacgtgc tcaaacgcca
      301 gggaagaacc ctgtaaggct ttggcggtta agtgaggcca ggcctttcct tgcaatatcg
      361 ttaatggccc ttttcagggc cgcgta
//
