LOCUS       NM_003540                401 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H4 clustered histone 6 (H4C6), mRNA.
ACCESSION   NM_003540
VERSION     NM_003540.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Qian,T., Zhou,Z., Zhang,Q., Liou,Y.L. and Zhou,H.
  TITLE     SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A
            reflection of potential minimally invasive biomarkers for early
            screening of nasopharyngeal cancer
  JOURNAL   Medicine (Baltimore) 102 (50), e36583 (2023)
   PUBMED   38115290
  REMARK    GeneRIF: SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal
            swabs: A reflection of potential minimally invasive biomarkers for
            early screening of nasopharyngeal cancer.
REFERENCE   2  (bases 1 to 401)
  AUTHORS   Varol,N., Keles,I., Yildiz,H., Karaosmanoglu,C., Karalar,M.,
            Zengin,K., Sarici,H. and Tokyol,C.
  TITLE     Methylation analysis of histone 4-related gene HIST1H4F and its
            effect on gene expression in bladder cancer
  JOURNAL   Gene 866, 147352 (2023)
   PUBMED   36898511
  REMARK    GeneRIF: Methylation analysis of histone 4-related gene HIST1H4F
            and its effect on gene expression in bladder cancer.
REFERENCE   3  (bases 1 to 401)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 401)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 401)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 401)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 401)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   8  (bases 1 to 401)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   9  (bases 1 to 401)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
REFERENCE   10 (bases 1 to 401)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003540.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC093763.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000244537.6/
                                             ENSP00000244537.6
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AL031777.5         45775-46175
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..401
                     /gene="H4C6"
                     /gene_synonym="H4; H4-16; H4/c; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C8; H4C9;
                     H4FC; HIST1H4F"
                     /note="H4 clustered histone 6"
                     /db_xref="GeneID:8361"
                     /db_xref="HGNC:HGNC:4783"
                     /db_xref="MIM:602824"
     exon            1..401
                     /gene="H4C6"
                     /gene_synonym="H4; H4-16; H4/c; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C8; H4C9;
                     H4FC; HIST1H4F"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..345
                     /gene="H4C6"
                     /gene_synonym="H4; H4-16; H4/c; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C8; H4C9;
                     H4FC; HIST1H4F"
                     /note="H4 histone family, member C; histone 1, H4f;
                     histone cluster 1, H4f; histone cluster 1 H4 family member
                     f"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_003531.1"
                     /db_xref="CCDS:CCDS4598.1"
                     /db_xref="GeneID:8361"
                     /db_xref="HGNC:HGNC:4783"
                     /db_xref="MIM:602824"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
ORIGIN      
        1 gcaaaagtta agagttgttg tttgtcttcg atcatgtctg gtagaggcaa aggtggtaaa
       61 ggtttaggaa agggaggcgc caagcgccat cgcaaagtgc tgcgtgacaa catacagggc
      121 atcacgaagc ccgccatccg tcgcttggcc cgacgcggcg gcgtgaaacg catttcgggc
      181 ctcatttatg aggagacccg cggtgttctt aaggtgttcc tggagaatgt gatacgggac
      241 gccgtaacct acacggagca cgccaagcgt aagacagtca ctgcaatgga tgttgtctac
      301 gcgctcaagc gccagggacg cactctgtac ggctttggtg gctgagcctc accccggctt
      361 tttatttaac agctcaccca taaaaggccc ttttcagggc c
//
