LOCUS       NM_003545                412 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H4 clustered histone 5 (H4C5), mRNA.
ACCESSION   NM_003545
VERSION     NM_003545.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Borja,N., Borjas-Mendoza,P., Bivona,S., Peart,L., Gonzalez,J.,
            Johnson,B.K., Guo,S., Yusupov,R., Bademci,G. and Tekin,M.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     H4C5 missense variant leads to a neurodevelopmental phenotype
            overlapping with Angelman syndrome
  JOURNAL   Am J Med Genet A 191 (7), 1911-1916 (2023)
   PUBMED   36987712
  REMARK    GeneRIF: H4C5 missense variant leads to a neurodevelopmental
            phenotype overlapping with Angelman syndrome.
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 412)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 412)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   5  (bases 1 to 412)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 412)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 412)
  AUTHORS   Aziz,F., van Wijnen,A.J., Vaughan,P.S., Wu,S., Shakoori,A.R.,
            Lian,J.B., Soprano,K.J., Stein,J.L. and Stein,G.S.
  TITLE     The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and
            H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled
            human histone H4 gene: mechanistic differences between distinct H4
            genes
  JOURNAL   Mol Biol Rep 25 (1), 1-12 (1998)
   PUBMED   9540062
REFERENCE   8  (bases 1 to 412)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 412)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 412)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003545.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA880386.1, DA283941.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000615164.3/
                                             ENSP00000484789.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AL031777.5         9992-10403
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..412
                     /gene="H4C5"
                     /gene_synonym="H4-16; H4/j; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C6; H4C8; H4C9;
                     H4FJ; HIST1H4E; TEBIVANED3; TEVANED3"
                     /note="H4 clustered histone 5"
                     /db_xref="GeneID:8367"
                     /db_xref="HGNC:HGNC:4790"
                     /db_xref="MIM:602830"
     exon            1..412
                     /gene="H4C5"
                     /gene_synonym="H4-16; H4/j; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C6; H4C8; H4C9;
                     H4FJ; HIST1H4E; TEBIVANED3; TEVANED3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..347
                     /gene="H4C5"
                     /gene_synonym="H4-16; H4/j; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C6; H4C8; H4C9;
                     H4FJ; HIST1H4E; TEBIVANED3; TEVANED3"
                     /note="H4 histone family, member J; histone 1, H4e;
                     histone cluster 1 H4 family member e; histone cluster 1,
                     H4e"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_003536.1"
                     /db_xref="CCDS:CCDS4593.1"
                     /db_xref="GeneID:8367"
                     /db_xref="HGNC:HGNC:4790"
                     /db_xref="MIM:602830"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
ORIGIN      
        1 agatttttgc ggctattttc gttggtgtgt tggtcatgtc tggtcgcggc aaaggcggaa
       61 agggactggg taaaggaggc gctaagcgtc accgtaaggt cctgcgagat aacatccagg
      121 gcattaccaa gcctgccatc cggcgccttg ctcgtcgcgg gggtgtcaag cgcatttctg
      181 gtctcatcta cgaggagact cgcggggttc tgaaggtgtt tctggaaaac gtgattcgtg
      241 atgctgtgac ttacacggag cacgccaaac gcaagacagt gacagcgatg gatgtggtct
      301 acgcgctgaa gagacaggga cgcactcttt acggcttcgg cggctaatgc taccgcttaa
      361 acgactcagc atctcgactt cccaaatcaa aggccctttt cagggccgcc ca
//
