LOCUS       NM_175054                412 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens H4 histone 16 (H4C16), mRNA.
ACCESSION   NM_175054
VERSION     NM_175054.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 412)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   4  (bases 1 to 412)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 412)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 412)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 412)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   8  (bases 1 to 412)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 412)
  AUTHORS   Aziz,F., van Wijnen,A.J., Vaughan,P.S., Wu,S., Shakoori,A.R.,
            Lian,J.B., Soprano,K.J., Stein,J.L. and Stein,G.S.
  TITLE     The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and
            H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled
            human histone H4 gene: mechanistic differences between distinct H4
            genes
  JOURNAL   Mol Biol Rep 25 (1), 1-12 (1998)
   PUBMED   9540062
REFERENCE   10 (bases 1 to 412)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010168.6.
            
            On Feb 19, 2003 this sequence version replaced NM_175054.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB291731.1, DA857331.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000539745.2/
                                             ENSP00000443017.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AC010168.6         20043-20454
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..412
                     /gene="H4C16"
                     /gene_synonym="H4-16; H4/p; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST4H4"
                     /note="H4 histone 16"
                     /db_xref="GeneID:121504"
                     /db_xref="HGNC:HGNC:20510"
                     /db_xref="MIM:615069"
     exon            1..412
                     /gene="H4C16"
                     /gene_synonym="H4-16; H4/p; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST4H4"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..359
                     /gene="H4C16"
                     /gene_synonym="H4-16; H4/p; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST4H4"
                     /note="histone 4, H4; histone cluster 4 H4"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_778224.1"
                     /db_xref="CCDS:CCDS8665.1"
                     /db_xref="GeneID:121504"
                     /db_xref="HGNC:HGNC:20510"
                     /db_xref="MIM:615069"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
ORIGIN      
        1 acagtgggca gcccgatttt ctgctgagta ggcgctgtga tttcagaatg tctgggcgag
       61 gtaaaggtgg caaggggctg ggtaagggag gcgccaagcg ccaccggaag gtgctgcggg
      121 acaatatcca aggcattaca aagccggcga ttcgccgtct cgcccgacgt gggggcgtca
      181 agcgcatttc tggtctcatc tacgaggaga cccggggagt cctcaaagtc ttcctggaga
      241 acgtgatccg tgacgcggtg acttacacgg agcacgccaa gcgcaagacc gtcacggcca
      301 tggatgtggt gtacgcgctg aaacgccagg gtcgcaccct ttatggtttc ggcggttgag
      361 ctgtccccac agcttctcta cagactccaa aaggcccttt tcagggcccc ca
//
