LOCUS       NM_001034077             396 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens H4 clustered histone 15 (H4C15), transcript variant 1,
            mRNA.
ACCESSION   NM_001034077
VERSION     NM_001034077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 396)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   4  (bases 1 to 396)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 396)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   6  (bases 1 to 396)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 396)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   8  (bases 1 to 396)
  AUTHORS   Aziz,F., van Wijnen,A.J., Vaughan,P.S., Wu,S., Shakoori,A.R.,
            Lian,J.B., Soprano,K.J., Stein,J.L. and Stein,G.S.
  TITLE     The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and
            H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled
            human histone H4 gene: mechanistic differences between distinct H4
            genes
  JOURNAL   Mol Biol Rep 25 (1), 1-12 (1998)
   PUBMED   9540062
REFERENCE   9  (bases 1 to 396)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
REFERENCE   10 (bases 1 to 396)
  AUTHORS   Green,L., Van Antwerpen,R., Stein,J., Stein,G., Tripputi,P.,
            Emanuel,B., Selden,J. and Croce,C.
  TITLE     A major human histone gene cluster on the long arm of chromosome 1
  JOURNAL   Science 226 (4676), 838-840 (1984)
   PUBMED   6494913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            On Jun 2, 2006 this sequence version replaced NM_001034077.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene encodes a
            replication-dependent histone that is a member of the histone H4
            family. Some transcripts from this gene lack polyA tails; instead,
            they contain a palindromic termination element. This gene is found
            in a histone cluster on chromosome 1. This gene is one of four
            histone genes in the cluster that are duplicated; this record
            represents the telomeric copy. [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA438762.1, DA376610.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000579512.3/
                                             ENSP00000462355.1
            RefSeq Select criteria        :: based on conservation, longest
                                             protein
            replication-dependent histone :: PMID: 15527963
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               AC239868.2         145334-145729       c
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..396
                     /gene="H4C15"
                     /gene_synonym="H4-16; H4/o; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST2H4B"
                     /note="H4 clustered histone 15"
                     /db_xref="GeneID:554313"
                     /db_xref="HGNC:HGNC:29607"
     exon            1..396
                     /gene="H4C15"
                     /gene_synonym="H4-16; H4/o; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST2H4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..340
                     /gene="H4C15"
                     /gene_synonym="H4-16; H4/o; H4C1; H4C11; H4C12; H4C13;
                     H4C14; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9;
                     HIST2H4B"
                     /note="histone 2, H4b; histone cluster 2, H4b; histone
                     cluster 2 H4 family member b"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_001029249.1"
                     /db_xref="CCDS:CCDS30851.1"
                     /db_xref="GeneID:554313"
                     /db_xref="HGNC:HGNC:29607"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
ORIGIN      
        1 agaagctgtc tatcgggctc cagcggtcat gtccggcaga ggaaagggcg gaaaaggctt
       61 aggcaaaggg ggcgctaagc gccaccgcaa ggtcttgaga gacaacattc agggcatcac
      121 caagcctgcc attcggcgtc tagctcggcg tggcggcgtt aagcggatct ctggcctcat
      181 ttacgaggag acccgcggtg tgctgaaggt gttcctggag aatgtgattc gggacgcagt
      241 cacctacacc gagcacgcca agcgcaagac cgtcacagcc atggatgtgg tgtacgcgct
      301 caagcgccag gggcgcaccc tgtacggctt cggaggctag gccgccgctc cagctttgca
      361 cgtttcgatc ccaaaggccc tttttagggc cgacca
//
