LOCUS       NM_003548                396 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens H4 clustered histone 14 (H4C14), mRNA.
ACCESSION   NM_003548 XM_001124639
VERSION     NM_003548.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Pan,R.Y., He,L., Zhang,J., Liu,X., Liao,Y., Gao,J., Liao,Y.,
            Yan,Y., Li,Q., Zhou,X., Cheng,J., Xing,Q., Guan,F., Zhang,J.,
            Sun,L. and Yuan,Z.
  TITLE     Positive feedback regulation of microglial glucose metabolism by
            histone H4 lysine 12 lactylation in Alzheimer's disease
  JOURNAL   Cell Metab 34 (4), 634-648 (2022)
   PUBMED   35303422
  REMARK    GeneRIF: Positive feedback regulation of microglial glucose
            metabolism by histone H4 lysine 12 lactylation in Alzheimer's
            disease.
REFERENCE   3  (bases 1 to 396)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 396)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 396)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   6  (bases 1 to 396)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 396)
  AUTHORS   Pelicci,G., Lanfrancone,L., Salcini,A.E., Romano,A., Mele,S.,
            Grazia Borrello,M., Segatto,O., Di Fiore,P.P. and Pelicci,P.G.
  TITLE     Constitutive phosphorylation of Shc proteins in human tumors
  JOURNAL   Oncogene 11 (5), 899-907 (1995)
   PUBMED   7675449
REFERENCE   8  (bases 1 to 396)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
REFERENCE   9  (bases 1 to 396)
  AUTHORS   Green,L., Van Antwerpen,R., Stein,J., Stein,G., Tripputi,P.,
            Emanuel,B., Selden,J. and Croce,C.
  TITLE     A major human histone gene cluster on the long arm of chromosome 1
  JOURNAL   Science 226 (4676), 838-840 (1984)
   PUBMED   6494913
REFERENCE   10 (bases 1 to 396)
  AUTHORS   Sierra,F., Stein,G. and Stein,J.
  TITLE     Structure and in vitro transcription of a human H4 histone gene
  JOURNAL   Nucleic Acids Res 11 (20), 7069-7086 (1983)
   PUBMED   6314274
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            On or before Sep 20, 2006 this sequence version replaced
            XM_001124639.1, NM_003548.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in a
            histone cluster on chromosome 1. This gene is one of four histone
            genes in the cluster that are duplicated; this record represents
            the centromeric copy. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB014249.1, DA456913.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000578186.3/
                                             ENSP00000462667.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               AC239868.2         117227-117622
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..396
                     /gene="H4C14"
                     /gene_synonym="FO108; H4; H4-16; H4/n; H4C1; H4C11; H4C12;
                     H4C13; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8;
                     H4C9; H4F2; H4FN; HIST2H4; HIST2H4A"
                     /note="H4 clustered histone 14"
                     /db_xref="GeneID:8370"
                     /db_xref="HGNC:HGNC:4794"
                     /db_xref="MIM:142750"
     exon            1..396
                     /gene="H4C14"
                     /gene_synonym="FO108; H4; H4-16; H4/n; H4C1; H4C11; H4C12;
                     H4C13; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8;
                     H4C9; H4F2; H4FN; HIST2H4; HIST2H4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..340
                     /gene="H4C14"
                     /gene_synonym="FO108; H4; H4-16; H4/n; H4C1; H4C11; H4C12;
                     H4C13; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8;
                     H4C9; H4F2; H4FN; HIST2H4; HIST2H4A"
                     /note="H4 histone family, member N; histone cluster 2 H4
                     family member a; H4 histone, family 2; histone 2, H4a;
                     histone IV, family 2; histone cluster 2, H4a"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_003539.1"
                     /db_xref="CCDS:CCDS30847.1"
                     /db_xref="GeneID:8370"
                     /db_xref="HGNC:HGNC:4794"
                     /db_xref="MIM:142750"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
ORIGIN      
        1 agaagctgtc tatcgggctc cagcggtcat gtccggcaga ggaaagggcg gaaaaggctt
       61 aggcaaaggg ggcgctaagc gccaccgcaa ggtcttgaga gacaacattc agggcatcac
      121 caagcctgcc attcggcgtc tagctcggcg tggcggcgtt aagcggatct ctggcctcat
      181 ttacgaggag acccgcggtg tgctgaaggt gttcctggag aatgtgattc gggacgcagt
      241 cacctacacc gagcacgcca agcgcaagac cgtcacagcc atggatgtgg tgtacgcgct
      301 caagcgccag gggcgcaccc tgtacggctt cggaggctag gccgccgctc cagctttgca
      361 cgtttcgatc ccaaaggccc tttttagggc cgacca
//
