LOCUS       NM_021968                389 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H4 clustered histone 11 (H4C11), mRNA.
ACCESSION   NM_021968
VERSION     NM_021968.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 389)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   4  (bases 1 to 389)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 389)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 389)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 389)
  AUTHORS   Aziz,F., van Wijnen,A.J., Vaughan,P.S., Wu,S., Shakoori,A.R.,
            Lian,J.B., Soprano,K.J., Stein,J.L. and Stein,G.S.
  TITLE     The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and
            H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled
            human histone H4 gene: mechanistic differences between distinct H4
            genes
  JOURNAL   Mol Biol Rep 25 (1), 1-12 (1998)
   PUBMED   9540062
REFERENCE   8  (bases 1 to 389)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 389)
  AUTHORS   Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.
  TITLE     Protein-DNA interactions in vivo upstream of a cell cycle-regulated
            human H4 histone gene
  JOURNAL   Science 236 (4806), 1308-1311 (1987)
   PUBMED   3035717
REFERENCE   10 (bases 1 to 389)
  AUTHORS   Heintz,N., Zernik,M. and Roeder,R.G.
  TITLE     The structure of the human histone genes: clustered but not
            tandemly repeated
  JOURNAL   Cell 24 (3), 661-668 (1981)
   PUBMED   6265100
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049822.30.
            
            On Dec 3, 2019 this sequence version replaced NM_021968.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC017361.2, BU849117.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000355057.3/
                                             ENSP00000347168.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AL049822.30        12439-12827
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..389
                     /gene="H4C11"
                     /gene_synonym="dJ160A22.2; H4-16; H4/e; H4C1; H4C12;
                     H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6;
                     H4C8; H4C9; H4F2iv; H4FE; HIST1H4J; TEBIVANED2; TEVANED2"
                     /note="H4 clustered histone 11"
                     /db_xref="GeneID:8363"
                     /db_xref="HGNC:HGNC:4785"
                     /db_xref="MIM:602826"
     exon            1..389
                     /gene="H4C11"
                     /gene_synonym="dJ160A22.2; H4-16; H4/e; H4C1; H4C12;
                     H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6;
                     H4C8; H4C9; H4F2iv; H4FE; HIST1H4J; TEBIVANED2; TEVANED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..345
                     /gene="H4C11"
                     /gene_synonym="dJ160A22.2; H4-16; H4/e; H4C1; H4C12;
                     H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6;
                     H4C8; H4C9; H4F2iv; H4FE; HIST1H4J; TEBIVANED2; TEVANED2"
                     /note="H4 histone family, member E; histone 1, H4j;
                     histone cluster 1, H4j; histone cluster 1 H4 family member
                     j"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_068803.1"
                     /db_xref="CCDS:CCDS4630.1"
                     /db_xref="GeneID:8363"
                     /db_xref="HGNC:HGNC:4785"
                     /db_xref="MIM:602826"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     regulatory      361..366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H4C11"
                     /gene_synonym="dJ160A22.2; H4-16; H4/e; H4C1; H4C12;
                     H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6;
                     H4C8; H4C9; H4F2iv; H4FE; HIST1H4J; TEBIVANED2; TEVANED2"
                     /note="hexamer: AATAAA"
     polyA_site      389
                     /gene="H4C11"
                     /gene_synonym="dJ160A22.2; H4-16; H4/e; H4C1; H4C12;
                     H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6;
                     H4C8; H4C9; H4F2iv; H4FE; HIST1H4J; TEBIVANED2; TEVANED2"
                     /note="major polyA site"
ORIGIN      
        1 acaaagcgtt gggtgagact cctcttgctc gtcatgtctg gccgcggcaa aggcgggaag
       61 ggtcttggca aaggcggcgc taagcgccac cgtaaagtac tgcgcgacaa tatccagggc
      121 atcaccaagc cggccatccg gcgccttgct cgccgcggcg gcgtgaagcg catctccggc
      181 ctcatctacg aggagactcg cggggtgctg aaggtgttcc tggagaacgt gatccgggac
      241 gccgtgacct atacagagca cgccaagcgc aagacggtca ccgccatgga tgtggtctac
      301 gcgctcaagc gccagggccg caccctctac ggtttcggtg gttgagcgtc cctttctatc
      361 aataaaaggc ccttttcagg gccacccta
//
