LOCUS       NM_001355258             982 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens H3.Y histone 1 (H3Y1), mRNA.
ACCESSION   NM_001355258
VERSION     NM_001355258.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 982)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 982)
  AUTHORS   Resnick,R., Wong,C.J., Hamm,D.C., Bennett,S.R., Skene,P.J.,
            Hake,S.B., Henikoff,S., van der Maarel,S.M. and Tapscott,S.J.
  TITLE     DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes
            for Expression
  JOURNAL   Cell Rep 29 (7), 1812-1820 (2019)
   PUBMED   31722199
  REMARK    GeneRIF: DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4
            Target Genes for Expression.
REFERENCE   3  (bases 1 to 982)
  AUTHORS   Zink,L.M., Delbarre,E., Eberl,H.C., Keilhauer,E.C., Bonisch,C.,
            Punzeler,S., Bartkuhn,M., Collas,P., Mann,M. and Hake,S.B.
  TITLE     H3.Y discriminates between HIRA and DAXX chaperone complexes and
            reveals unexpected insights into human DAXX-H3.3-H4 binding and
            deposition requirements
  JOURNAL   Nucleic Acids Res 45 (10), 5691-5706 (2017)
   PUBMED   28334823
  REMARK    GeneRIF: H3.Y discriminates between HIRA and DAXX chaperone
            complexes and reveals unexpected insights into human DAXX-H3.3-H4
            binding and deposition requirements.
REFERENCE   4  (bases 1 to 982)
  AUTHORS   Kujirai,T., Horikoshi,N., Sato,K., Maehara,K., Machida,S.,
            Osakabe,A., Kimura,H., Ohkawa,Y. and Kurumizaka,H.
  TITLE     Structure and function of human histone H3.Y nucleosome
  JOURNAL   Nucleic Acids Res 44 (13), 6127-6141 (2016)
   PUBMED   27016736
  REMARK    GeneRIF: ken together, H3.Y-containing nucleosomes around
            transcription start sites may form relaxed chromatin that allows
            transcription factor access, to regulate the transcription status
            of specific genes.
            Erratum:[Nucleic Acids Res. 2017 Apr 7;45(6):3612. doi:
            10.1093/nar/gkw1219.. PMID: 27913734]
REFERENCE   5  (bases 1 to 982)
  AUTHORS   Sadakierska-Chudy,A., Kostrzewa,R.M. and Filip,M.
  TITLE     A comprehensive view of the epigenetic landscape part I: DNA
            methylation, passive and active DNA demethylation pathways and
            histone variants
  JOURNAL   Neurotox Res 27 (1), 84-97 (2015)
   PUBMED   25362550
  REMARK    Review article
REFERENCE   6  (bases 1 to 982)
  AUTHORS   Szenker,E., Ray-Gallet,D. and Almouzni,G.
  TITLE     The double face of the histone variant H3.3
  JOURNAL   Cell Res 21 (3), 421-434 (2011)
   PUBMED   21263457
  REMARK    Review article
REFERENCE   7  (bases 1 to 982)
  AUTHORS   Wiedemann,S.M., Mildner,S.N., Bonisch,C., Israel,L., Maiser,A.,
            Matheisl,S., Straub,T., Merkl,R., Leonhardt,H., Kremmer,E.,
            Schermelleh,L. and Hake,S.B.
  TITLE     Identification and characterization of two novel primate-specific
            histone H3 variants, H3.X and H3.Y
  JOURNAL   J Cell Biol 190 (5), 777-791 (2010)
   PUBMED   20819935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC233724.2.
            
            On Jul 26, 2019 this sequence version replaced NM_001355258.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598383.3/ ENSP00000496014.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-982               AC233724.2         74320-75301         c
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..982
                     /gene="H3Y1"
                     /gene_synonym="H3.Y; H3.Y.1"
                     /note="H3.Y histone 1"
                     /db_xref="GeneID:391769"
                     /db_xref="HGNC:HGNC:43735"
     exon            1..982
                     /gene="H3Y1"
                     /gene_synonym="H3.Y; H3.Y.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..722
                     /gene="H3Y1"
                     /gene_synonym="H3.Y; H3.Y.1"
                     /note="H3 histone, family 3B (H3.3B) pseudogene; histone
                     cluster 2, H3c pseudogene; histone H3.Y1"
                     /codon_start=1
                     /product="histone H3.Y"
                     /protein_id="NP_001342187.1"
                     /db_xref="CCDS:CCDS87290.1"
                     /db_xref="GeneID:391769"
                     /db_xref="HGNC:HGNC:43735"
                     /translation="MARTKQTARKATAWQAPRKPLATKAAGKRAPPTGGIKKPHRYKP
                     GTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLV
                     QLFEDTNLCAIHARRVTIMPRDMQLARRLRREGP"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3Y1"
                     /gene_synonym="H3.Y; H3.Y.1"
                     /note="hexamer: AATAAA"
     polyA_site      982
                     /gene="H3Y1"
                     /gene_synonym="H3.Y; H3.Y.1"
                     /note="major polyA site"
ORIGIN      
        1 acagagatct ccagtcagaa agagactgcc tgcgagggag attcctggct gctgctttgt
       61 agaccaagga aacccaggac cctccggaaa gactaagcag cgcggcctcc gacccacaga
      121 cctgagggct ggtaagtgtg gggctgggtt ggcaggggct aagtgtgtgg gagagtcatg
      181 cgcatggatc tcaactcaca ggctctctga atcctgtcca cagcaccact gccctcgctc
      241 tctgacgcca gcaccgcctg cagccggcca ggctcagccc aaggacaggg gagaggctaa
      301 ggccccgcga catggcgcgc accaagcaga ccgcccgcaa agccaccgcc tggcaggccc
      361 ccaggaagcc cctggccacc aaagcagccg gaaaaagggc gccgcctaca ggagggatca
      421 agaagcctca ccgctacaag cctggcaccc tggcgctgcg ggaaatcaga aagtaccaga
      481 agtccacgca gctgctcctg cgcaagctgc ccttccagcg cctggtgcgc gagatcgccc
      541 aggccatcag cccggacctg cgcttccaga gtgcggccat tggcgccctg caggaggcca
      601 gcgaggccta cctggtgcag ctctttgaag acaccaacct gtgtgccatc catgccaggc
      661 gcgtcacaat tatgccccga gacatgcagc tggcccgccg cctccgcaga gagggtcctt
      721 aagagcccaa aggtagctaa gcataggatt gggagtggaa acaggcagaa atcaggtctt
      781 ggtggtgttt ctgtgtgctt ttgtttgtta atgtctaatc taccttgagg gtcataaggc
      841 actagtgtca ggtgggaatg tttcagtgag cgagtttcag cacttcagct ctacatcaat
      901 tttcaagaaa cctgttcatt ttcactggac tatgcctgtg tttagactac ttcaaaccaa
      961 ataaatctct tcctgatggc aa
//
