LOCUS       NM_003534                496 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H3 clustered histone 8 (H3C8), mRNA.
ACCESSION   NM_003534
VERSION     NM_003534.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 496)
  AUTHORS   Rea,S., Eisenhaber,F., O'Carroll,D., Strahl,B.D., Sun,Z.W.,
            Schmid,M., Opravil,S., Mechtler,K., Ponting,C.P., Allis,C.D. and
            Jenuwein,T.
  TITLE     Regulation of chromatin structure by site-specific histone H3
            methyltransferases
  JOURNAL   Nature 406 (6796), 593-599 (2000)
   PUBMED   10949293
REFERENCE   7  (bases 1 to 496)
  AUTHORS   Hsu,J.Y., Sun,Z.W., Li,X., Reuben,M., Tatchell,K., Bishop,D.K.,
            Grushcow,J.M., Brame,C.J., Caldwell,J.A., Hunt,D.F., Lin,R.,
            Smith,M.M. and Allis,C.D.
  TITLE     Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora
            kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
  JOURNAL   Cell 102 (3), 279-291 (2000)
   PUBMED   10975519
REFERENCE   8  (bases 1 to 496)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 496)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 496)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003534.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BG327264.1, CV028635.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000614378.2/
                                             ENSP00000484638.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AL031777.5         76300-76795         c
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..496
                     /gene="H3C8"
                     /gene_synonym="H3/h; H3C1; H3C10; H3C11; H3C12; H3C2;
                     H3C3; H3C4; H3C6; H3C7; H3FH; HIST1H3G"
                     /note="H3 clustered histone 8"
                     /db_xref="GeneID:8355"
                     /db_xref="HGNC:HGNC:4772"
                     /db_xref="MIM:602815"
     exon            1..496
                     /gene="H3C8"
                     /gene_synonym="H3/h; H3C1; H3C10; H3C11; H3C12; H3C2;
                     H3C3; H3C4; H3C6; H3C7; H3FH; HIST1H3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..440
                     /gene="H3C8"
                     /gene_synonym="H3/h; H3C1; H3C10; H3C11; H3C12; H3C2;
                     H3C3; H3C4; H3C6; H3C7; H3FH; HIST1H3G"
                     /note="H3 histone family, member H; histone 1, H3g;
                     histone H3/h; histone cluster 1 H3 family member g;
                     histone cluster 1, H3g"
                     /codon_start=1
                     /product="histone H3.1"
                     /protein_id="NP_003525.1"
                     /db_xref="CCDS:CCDS4602.1"
                     /db_xref="GeneID:8355"
                     /db_xref="HGNC:HGNC:4772"
                     /db_xref="MIM:602815"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 ggctgagttt ttctttcagg tagtctgaga tggcccgcac caagcagact gcacgcaagt
       61 ccaccggtgg caaagcgccg cgcaagcagc tggccactaa ggcggctcgg aaaagcgcgc
      121 cggccaccgg cggcgtgaag aaacctcatc gctaccgtcc cggcaccgtg gctctgcgcg
      181 agattcgccg ctatcagaag tcgactgagc tgctgatccg caagttgcct ttccaacgcc
      241 tggtgcgaga aatcgctcag gacttcaaga cagatctgcg ctttcagagt tccgcggtga
      301 tggccctgca ggaggcctgc gaggcctact tggtggggct ctttgaggat accaacctgt
      361 gtgccatcca tgctaagcga gtgactatca tgcccaagga cattcagctc gctcgccgca
      421 ttcgtgggga gagagcgtag aggtttccgg gcagtaattc tatccaactt aaaaaggctc
      481 ttttaagagc cgccta
//
