LOCUS       NM_003537                511 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H3 clustered histone 2 (H3C2), mRNA.
ACCESSION   NM_003537
VERSION     NM_003537.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Acosta,A.M., McKenney,J.K., Sholl,L.M., Dickson,B.C., Matoso,A.,
            Lu,H., Jo,V.Y., Collins,K., Ulbright,T.M. and Fletcher,C.D.M.
  TITLE     Molecular assessment of paratesticular rhabdomyomas demonstrates
            recurrent findings, including a novel H3C2 p.K37I mutation
  JOURNAL   Mod Pathol 35 (12), 1921-1928 (2022)
   PUBMED   35842480
  REMARK    GeneRIF: Molecular assessment of paratesticular rhabdomyomas
            demonstrates recurrent findings, including a novel H3C2 p.K37I
            mutation.
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 511)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   4  (bases 1 to 511)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 511)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 511)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 511)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
REFERENCE   8  (bases 1 to 511)
  AUTHORS   Marashi,F., Helms,S., Shiels,A., Silverstein,S., Greenspan,D.S.,
            Stein,G. and Stein,J.
  TITLE     Enhancer-facilitated expression of prokaryotic and eukaryotic genes
            using human histone gene 5' regulatory sequences
  JOURNAL   Biochem Cell Biol 64 (4), 277-289 (1986)
   PUBMED   3013246
REFERENCE   9  (bases 1 to 511)
  AUTHORS   Zhong,R., Roeder,R.G. and Heintz,N.
  TITLE     The primary structure and expression of four cloned human histone
            genes
  JOURNAL   Nucleic Acids Res 11 (21), 7409-7425 (1983)
   PUBMED   6647026
REFERENCE   10 (bases 1 to 511)
  AUTHORS   Ohe,Y. and Iwai,K.
  TITLE     Human spleen histone H3. Isolation and amino acid sequence
  JOURNAL   J Biochem 90 (4), 1205-1211 (1981)
   PUBMED   7309716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003537.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA003006.1, BP872375.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000621411.3/
                                             ENSP00000484841.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               U91328.1           108960-109470
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..511
                     /gene="H3C2"
                     /gene_synonym="H3/l; H3C1; H3C10; H3C11; H3C12; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FL; HIST1H3B"
                     /note="H3 clustered histone 2"
                     /db_xref="GeneID:8358"
                     /db_xref="HGNC:HGNC:4776"
                     /db_xref="MIM:602819"
     exon            1..511
                     /gene="H3C2"
                     /gene_synonym="H3/l; H3C1; H3C10; H3C11; H3C12; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FL; HIST1H3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..450
                     /gene="H3C2"
                     /gene_synonym="H3/l; H3C1; H3C10; H3C11; H3C12; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FL; HIST1H3B"
                     /note="H3 histone family, member L; histone 1, H3b;
                     histone H3/l; histone cluster 1, H3b; histone cluster 1 H3
                     family member b"
                     /codon_start=1
                     /product="histone H3.1"
                     /protein_id="NP_003528.1"
                     /db_xref="CCDS:CCDS4573.1"
                     /db_xref="GeneID:8358"
                     /db_xref="HGNC:HGNC:4776"
                     /db_xref="MIM:602819"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 acagacgtct ctgcaggcaa gcttttctgt ggttttgcca tggctcgtac taaacagaca
       61 gctcggaaat ccaccggcgg taaagcgcca cgcaagcagc tggctaccaa ggctgctcgc
      121 aagagcgcgc cggctaccgg cggcgtgaaa aagcctcacc gttaccgccc gggcactgtg
      181 gctctgcgcg agatccgccg ctaccaaaag tcgaccgagt tgctgattcg gaagctgccg
      241 ttccagcgcc tggtgcgaga aatcgcccaa gacttcaaga ccgatcttcg cttccagagc
      301 tctgcggtga tggcgctgca ggaggcttgt gaggcctact tggtagggct ctttgaggac
      361 acaaaccttt gcgccatcca tgctaagcga gtgactatta tgcccaaaga catccagctc
      421 gctcgccgca ttcgcggaga aagagcgtaa atgtaaagtc actttttcat cagtcttaaa
      481 acccaaaggc tcttttcaga gccacccact t
//
