LOCUS       NM_001005464             518 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H3 clustered histone 15 (H3C15), mRNA.
ACCESSION   NM_001005464
VERSION     NM_001005464.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Hammond,C.M., Bao,H., Hendriks,I.A., Carraro,M., Garcia-Nieto,A.,
            Liu,Y., Reveron-Gomez,N., Spanos,C., Chen,L., Rappsilber,J.,
            Nielsen,M.L., Patel,D.J., Huang,H. and Groth,A.
  TITLE     DNAJC9 integrates heat shock molecular chaperones into the histone
            chaperone network
  JOURNAL   Mol Cell 81 (12), 2533-2548 (2021)
   PUBMED   33857403
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Braastad,C.D., Hovhannisyan,H., van Wijnen,A.J., Stein,J.L. and
            Stein,G.S.
  TITLE     Functional characterization of a human histone gene cluster
            duplication
  JOURNAL   Gene 342 (1), 35-40 (2004)
   PUBMED   15527963
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Goto,H., Tomono,Y., Ajiro,K., Kosako,H., Fujita,M., Sakurai,M.,
            Okawa,K., Iwamatsu,A., Okigaki,T., Takahashi,T. and Inagaki,M.
  TITLE     Identification of a novel phosphorylation site on histone H3
            coupled with mitotic chromosome condensation
  JOURNAL   J Biol Chem 274 (36), 25543-25549 (1999)
   PUBMED   10464286
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Marashi,F., Helms,S., Shiels,A., Silverstein,S., Greenspan,D.S.,
            Stein,G. and Stein,J.
  TITLE     Enhancer-facilitated expression of prokaryotic and eukaryotic genes
            using human histone gene 5' regulatory sequences
  JOURNAL   Biochem Cell Biol 64 (4), 277-289 (1986)
   PUBMED   3013246
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Green,L., Van Antwerpen,R., Stein,J., Stein,G., Tripputi,P.,
            Emanuel,B., Selden,J. and Croce,C.
  TITLE     A major human histone gene cluster on the long arm of chromosome 1
  JOURNAL   Science 226 (4676), 838-840 (1984)
   PUBMED   6494913
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Ohe,Y. and Iwai,K.
  TITLE     Human spleen histone H3. Isolation and amino acid sequence
  JOURNAL   J Biochem 90 (4), 1205-1211 (1981)
   PUBMED   7309716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            
            On Dec 3, 2019 this sequence version replaced NM_001005464.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in a
            histone cluster on chromosome 1. This gene is one of four histone
            genes in the cluster that are duplicated; this record represents
            the centromeric copy. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: HY085386.1, BE889837.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000403683.2/
                                             ENSP00000385479.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AC239868.2         137178-137695
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..518
                     /gene="H3C15"
                     /gene_synonym="H3/n; H3/o; H3C13; H3C14; HIST2H3A"
                     /note="H3 clustered histone 15"
                     /db_xref="GeneID:333932"
                     /db_xref="HGNC:HGNC:20505"
     exon            1..518
                     /gene="H3C15"
                     /gene_synonym="H3/n; H3/o; H3C13; H3C14; HIST2H3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..458
                     /gene="H3C15"
                     /gene_synonym="H3/n; H3/o; H3C13; H3C14; HIST2H3A"
                     /note="histone 2, H3a; histone H3/o; histone cluster 2,
                     H3a; histone cluster 2 H3 family member a; H3-clustered
                     histone 13; H3-clustered histone 14"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_001005464.1"
                     /db_xref="CCDS:CCDS30850.1"
                     /db_xref="GeneID:333932"
                     /db_xref="HGNC:HGNC:20505"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 gtttttctcc ccgccgctgc gctggtaagc ctgtgttttg gttcgctatg gcccgtacta
       61 agcagactgc tcgcaagtcg accggcggca aggccccgag gaagcagctg gccaccaagg
      121 cggcccgcaa gagcgcgccg gccacgggcg gggtgaagaa gccgcaccgc taccggcccg
      181 gcaccgtagc cctgcgggag atccggcgct accagaagtc cacggagctg ctgatccgca
      241 agctgccctt ccagcggctg gtacgcgaga tcgcgcagga ctttaagacg gacctgcgct
      301 tccagagctc ggccgtgatg gcgctgcagg aggccagcga ggcctacctg gtggggctgt
      361 tcgaagacac gaacctgtgc gccatccacg ccaagcgcgt gaccattatg cccaaggaca
      421 tccagctggc ccgccgcatc cgtggagagc gggcttaaga agtggcggtt cggccggagg
      481 ttccatcgta tccaaaaggc tcttttcaga gccaccca
//
