LOCUS       NM_003529                508 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens H3 clustered histone 1 (H3C1), mRNA.
ACCESSION   NM_003529
VERSION     NM_003529.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Zhang,Y., Jiang,H., Dong,M., Min,J., He,X., Tan,Y., Liu,F.,
            Chen,M., Chen,X., Yin,Q., Zheng,L., Shao,Y., Li,X. and Chen,H.
  TITLE     Macrophage MCT4 inhibition activates reparative genes and protects
            from atherosclerosis by histone H3 lysine 18 lactylation
  JOURNAL   Cell Rep 43 (5), 114180 (2024)
   PUBMED   38733581
  REMARK    GeneRIF: Macrophage MCT4 inhibition activates reparative genes and
            protects from atherosclerosis by histone H3 lysine 18 lactylation.
            Erratum:[Cell Rep. 2024 Oct 22;43(10):114884. doi:
            10.1016/j.celrep.2024.114884.. PMID: 39392757]
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 508)
  AUTHORS   Marsolier,J., Prompsy,P., Durand,A., Lyne,A.M., Landragin,C.,
            Trouchet,A., Bento,S.T., Eisele,A., Foulon,S., Baudre,L.,
            Grosselin,K., Bohec,M., Baulande,S., Dahmani,A., Sourd,L.,
            Letouze,E., Salomon,A.V., Marangoni,E., Perie,L. and Vallot,C.
  TITLE     H3K27me3 conditions chemotolerance in triple-negative breast cancer
  JOURNAL   Nat Genet 54 (4), 459-468 (2022)
   PUBMED   35410383
  REMARK    GeneRIF: H3K27me3 conditions chemotolerance in triple-negative
            breast cancer.
REFERENCE   4  (bases 1 to 508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 508)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 508)
  AUTHORS   Ahn,J. and Gruen,J.R.
  TITLE     The genomic organization of the histone clusters on human 6p21.3
  JOURNAL   Mamm Genome 10 (7), 768-770 (1999)
   PUBMED   10384058
REFERENCE   7  (bases 1 to 508)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   8  (bases 1 to 508)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 508)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 508)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003529.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC067490.1, CF272048.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000613854.2/
                                             ENSP00000480826.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               U91328.1           120101-120608       c
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..508
                     /gene="H3C1"
                     /gene_synonym="H3/A; H3C10; H3C11; H3C12; H3C2; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FA; HIST1H3A"
                     /note="H3 clustered histone 1"
                     /db_xref="GeneID:8350"
                     /db_xref="HGNC:HGNC:4766"
                     /db_xref="MIM:602810"
     exon            1..508
                     /gene="H3C1"
                     /gene_synonym="H3/A; H3C10; H3C11; H3C12; H3C2; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FA; HIST1H3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..450
                     /gene="H3C1"
                     /gene_synonym="H3/A; H3C10; H3C11; H3C12; H3C2; H3C3;
                     H3C4; H3C6; H3C7; H3C8; H3FA; HIST1H3A"
                     /note="H3 histone family, member A; histone 1, H3a;
                     histone cluster 1 H3 family member a; histone H3/a;
                     histone cluster 1, H3a"
                     /codon_start=1
                     /product="histone H3.1"
                     /protein_id="NP_003520.1"
                     /db_xref="CCDS:CCDS4570.1"
                     /db_xref="GeneID:8350"
                     /db_xref="HGNC:HGNC:4766"
                     /db_xref="MIM:602810"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 gcgctagtgt tgggtgttcc gctgtgctgt ttttccgtca tggctcgcac taagcaaact
       61 gctcggaagt ctactggtgg caaggcgcca cgcaaacagt tggccactaa ggcagcccgc
      121 aaaagcgctc cggccaccgg cggcgtgaaa aagccccacc gctaccggcc gggcaccgtg
      181 gctctgcgcg agatccgccg ttatcagaag tccactgaac tgcttattcg taaactacct
      241 ttccagcgcc tggtgcgcga gattgcgcag gactttaaaa cagacctgcg tttccagagc
      301 tccgctgtga tggctctgca ggaggcgtgc gaggcctact tggtagggct atttgaggac
      361 actaacctgt gcgccatcca cgccaagcgc gtcactatca tgcccaagga catccagctc
      421 gcccgccgca tccgcggaga gagggcgtga ttactgtggt ctctctgacg gtccaagcaa
      481 aggctctttt cagagccacc accttttc
//
