LOCUS       NM_001013699            1114 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens H3.5 histone (H3-5), mRNA.
ACCESSION   NM_001013699 XM_495919
VERSION     NM_001013699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1114)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1114)
  AUTHORS   Shiraishi,K., Shindo,A., Harada,A., Kurumizaka,H., Kimura,H.,
            Ohkawa,Y. and Matsuyama,H.
  TITLE     Roles of histone H3.5 in human spermatogenesis and spermatogenic
            disorders
  JOURNAL   Andrology 6 (1), 158-165 (2018)
   PUBMED   29179259
  REMARK    GeneRIF: H3.5 may play roles in DNA synthesis, but not apoptosis,
            and its expression is regulated by gonadotropins
REFERENCE   5  (bases 1 to 1114)
  AUTHORS   Urahama,T., Harada,A., Maehara,K., Horikoshi,N., Sato,K., Sato,Y.,
            Shiraishi,K., Sugino,N., Osakabe,A., Tachiwana,H., Kagawa,W.,
            Kimura,H., Ohkawa,Y. and Kurumizaka,H.
  TITLE     Histone H3.5 forms an unstable nucleosome and accumulates around
            transcription start sites in human testis
  JOURNAL   Epigenetics Chromatin 9, 2 (2016)
   PUBMED   26779285
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1114)
  AUTHORS   Sadakierska-Chudy,A., Kostrzewa,R.M. and Filip,M.
  TITLE     A comprehensive view of the epigenetic landscape part I: DNA
            methylation, passive and active DNA demethylation pathways and
            histone variants
  JOURNAL   Neurotox Res 27 (1), 84-97 (2015)
   PUBMED   25362550
  REMARK    Review article
REFERENCE   7  (bases 1 to 1114)
  AUTHORS   Schenk,R., Jenke,A., Zilbauer,M., Wirth,S. and Postberg,J.
  TITLE     H3.5 is a novel hominid-specific histone H3 variant that is
            specifically expressed in the seminiferous tubules of human testes
  JOURNAL   Chromosoma 120 (3), 275-285 (2011)
   PUBMED   21274551
  REMARK    GeneRIF: H3.5 preferentially colocalizes with euchromatin, and it
            is associated with actively transcribed genes and can replace an
            essential function of RNAi-depleted H3.3 in cell growth.
REFERENCE   8  (bases 1 to 1114)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023050.36.
            
            On Nov 23, 2018 this sequence version replaced NM_001013699.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene contains introns and its mRNA is
            polyadenylated, unlike most histone genes. The protein encoded by
            this gene is a replication-independent histone that is a member of
            the histone H3 family. [provided by RefSeq, Oct 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: HQ873957.1, BC066906.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000340398.5/
                                               ENSP00000339835.3
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 21274551
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1114              AC023050.36        17395-18508         c
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..1114
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /note="H3.5 histone"
                     /db_xref="GeneID:440093"
                     /db_xref="HGNC:HGNC:33164"
                     /db_xref="MIM:616134"
     exon            1..1114
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..540
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /note="histone variant H3.5; histone H3.5; H3 histone,
                     family 3C; H3 histone family member 3C"
                     /codon_start=1
                     /product="histone H3.3C"
                     /protein_id="NP_001013721.2"
                     /db_xref="CCDS:CCDS31769.1"
                     /db_xref="GeneID:440093"
                     /db_xref="HGNC:HGNC:33164"
                     /db_xref="MIM:616134"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPG
                     TVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVG
                     LLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     regulatory      864..869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
     regulatory      1093..1098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /note="hexamer: ATTAAA"
     polyA_site      1114
                     /gene="H3-5"
                     /gene_synonym="H3.3C; H3.5; H3F3C"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcagagc ggtttggtcg ttcgttggac cagtgtcggt tcttcgctcg cgactgcggc
       61 tcttcctcgg gcagcggaag cagcgcggag gtcggagaag tggcctaaaa cttcggcgtt
      121 gggtgaaaga aaatggcccg aaccaagcag actgctcgta aatccaccgg tgggaaagcc
      181 ccccgcaaac agctggccac gaaagctgcc aggaaaagca ccccctctac ctgcggggtg
      241 aagcctcatc gctacaggcc tgggaccgtg gcgcttcgag agattcgtcg ttatcagaag
      301 tcgaccgagc tgctcatccg gaagctgccc ttccagaggt tggtgaggga gatcgcgcag
      361 gatttcaaca ctgacctgag gtttcagagc gcagccgtcg gtgcgctgca ggaggctagc
      421 gaagcgtacc tggtgggtct gttggaagat actaacctgt gtgccatcca cgctaagaga
      481 gtcaccatca tgcccaaaga catccagttg gctcgccgga tacggggaga gagagcttaa
      541 gtgaaggcag tttttatggc attttgtagt aaattctgta aaatactttg gtttaattgg
      601 tgactttttt tgtaagaaat tgtttatatg ttgcatttgt acttaagtca ttccatcttt
      661 cactcaggat gaatgcgaaa agtgactgtt tacagacctc agtgatgtca gcactgttgc
      721 tcaggagtga caagttgtta atatgcaaaa cggatgcgtg atatttcttg cttctcatga
      781 tgcatgtttc tgtatgttaa tgacttgttg ggtagctatt aaggtactag aattgataaa
      841 tgtgtacaac agggtccttt tgcaataaaa ctggttatga cttgatccaa gtgtttaaca
      901 attggggctg ttaagtctga ccatacatca ctgtgataga atgtaggctt tttcaagggt
      961 gaagatacaa accttaacca cagtgtaact tatagtttcc tttaaaaaaa aaaaattaaa
     1021 cctggcagct atagaataca atatgtgcat ttataatagc tattttatat attgtagtgt
     1081 caacattttc aaattaaatg ttttacattc acaa
//
