LOCUS       NM_003493                516 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H3.4 histone, cluster member (H3-4), mRNA.
ACCESSION   NM_003493
VERSION     NM_003493.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Shirvaliloo,M.
  TITLE     The unfavorable clinical outcome of COVID-19 in smokers is mediated
            by H3K4me3, H3K9me3 and H3K27me3 histone marks
  JOURNAL   Epigenomics 14 (3), 153-162 (2022)
   PUBMED   35021853
  REMARK    GeneRIF: The unfavorable clinical outcome of COVID-19 in smokers is
            mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks.
            Review article
REFERENCE   3  (bases 1 to 516)
  AUTHORS   Ali,M.A.M., Garcia-Vilas,J.A., Cromwell,C.R., Hubbard,B.P.,
            Hendzel,M.J. and Schulz,R.
  TITLE     Matrix metalloproteinase-2 mediates ribosomal RNA transcription by
            cleaving nucleolar histones
  JOURNAL   FEBS J 288 (23), 6736-6751 (2021)
   PUBMED   34101354
  REMARK    GeneRIF: Matrix metalloproteinase-2 mediates ribosomal RNA
            transcription by cleaving nucleolar histones.
REFERENCE   4  (bases 1 to 516)
  AUTHORS   Basova,L., Lindsey,A., McGovern,A.M., Ellis,R.J. and
            Marcondes,M.C.G.
  TITLE     Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic
            Effects of Methamphetamine and Addiction Pathways in Postmortem
            HIV+ Brain Specimens that Are Not Amenable to Transcriptome
            Analysis
  JOURNAL   Viruses 13 (4), 544 (2021)
   PUBMED   33805201
  REMARK    GeneRIF: Detection of H3K4me3 Identifies NeuroHIV Signatures,
            Genomic Effects of Methamphetamine and Addiction Pathways in
            Postmortem HIV+ Brain Specimens that Are Not Amenable to
            Transcriptome Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 516)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 516)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 516)
  AUTHORS   Mizzen,C.A., Yang,X.J., Kokubo,T., Brownell,J.E., Bannister,A.J.,
            Owen-Hughes,T., Workman,J., Wang,L., Berger,S.L., Kouzarides,T.,
            Nakatani,Y. and Allis,C.D.
  TITLE     The TAF(II)250 subunit of TFIID has histone acetyltransferase
            activity
  JOURNAL   Cell 87 (7), 1261-1270 (1996)
   PUBMED   8980232
REFERENCE   8  (bases 1 to 516)
  AUTHORS   Ishimi,Y., Ichinose,S., Omori,A., Sato,K. and Kimura,H.
  TITLE     Binding of human minichromosome maintenance proteins with histone
            H3
  JOURNAL   J Biol Chem 271 (39), 24115-24122 (1996)
   PUBMED   8798650
REFERENCE   9  (bases 1 to 516)
  AUTHORS   Albig,W., Ebentheuer,J., Klobeck,G., Kunz,J. and Doenecke,D.
  TITLE     A solitary human H3 histone gene on chromosome 1
  JOURNAL   Hum Genet 97 (4), 486-491 (1996)
   PUBMED   8834248
REFERENCE   10 (bases 1 to 516)
  AUTHORS   Bernues,J., Espel,E. and Querol,E.
  TITLE     Identification of the core-histone-binding domains of HMG1 and HMG2
  JOURNAL   Biochim Biophys Acta 866 (4), 242-251 (1986)
   PUBMED   3697355
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139288.15.
            
            On Dec 3, 2019 this sequence version replaced NM_003493.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is located
            separately from the other H3 genes that are in the histone gene
            cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069079.1, DB026731.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000366696.2/
                                             ENSP00000355657.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AL139288.15        133005-133520
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..516
                     /gene="H3-4"
                     /gene_synonym="H3.4; H3/g; H3C16; H3FT; H3t; HIST3H3"
                     /note="H3.4 histone, cluster member"
                     /db_xref="GeneID:8290"
                     /db_xref="HGNC:HGNC:4778"
                     /db_xref="MIM:602820"
     exon            1..516
                     /gene="H3-4"
                     /gene_synonym="H3.4; H3/g; H3C16; H3FT; H3t; HIST3H3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..446
                     /gene="H3-4"
                     /gene_synonym="H3.4; H3/g; H3C16; H3FT; H3t; HIST3H3"
                     /note="H3 histone family, member T; histone 3, H3; H3/t;
                     histone cluster 3 H3; histone H3.4; H3.4 histone; H3
                     clustered histone 16"
                     /codon_start=1
                     /product="histone H3.1t"
                     /protein_id="NP_003484.1"
                     /db_xref="CCDS:CCDS1572.1"
                     /db_xref="GeneID:8290"
                     /db_xref="HGNC:HGNC:4778"
                     /db_xref="MIM:602820"
                     /translation="MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLV
                     GLFEDTNLCVIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 gcagaggaca ccgcggggcc aacagtttcg gattcatggc ccgaaccaag cagactgcgc
       61 gcaagtcaac gggtggcaag gcgccgcgca agcagctggc caccaaggtg gctcgcaaga
      121 gcgcacctgc cactggcggc gtgaagaagc cgcaccgcta ccggcccggc acggtggcgc
      181 ttcgcgagat ccgccgctac cagaagtcca ctgagctgct aatccgcaag ttgcccttcc
      241 agcggctgat gcgcgagatc gctcaggact ttaagaccga cctgcgcttc cagagctcgg
      301 ccgtgatggc gctgcaggag gcgtgcgagt cttacctggt ggggctgttt gaggacacca
      361 acctgtgtgt catccatgcc aaacgggtca ccatcatgcc taaggacatc cagctggcac
      421 gccgtatccg cggggagcgg gcctaggagg gctatctcgc cacctgagag gttgcgcaac
      481 gttcacccca aaggctcttt taagagccac ccacct
//
