LOCUS       NM_005324               2705 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens H3.3 histone B (H3-3B), mRNA.
ACCESSION   NM_005324
VERSION     NM_005324.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Voon,H.P.J., Hii,L., Garvie,A., Udugama,M., Krug,B., Russo,C.,
            Chueh,A.C., Daly,R.J., Morey,A., Bell,T.D.M., Turner,S.J.,
            Rosenbluh,J., Daniel,P., Firestein,R., Mann,J.R., Collas,P.,
            Jabado,N. and Wong,L.H.
  TITLE     Pediatric glioma histone H3.3 K27M/G34R mutations drive
            abnormalities in PML nuclear bodies
  JOURNAL   Genome Biol 24 (1), 284 (2023)
   PUBMED   38066546
  REMARK    GeneRIF: Pediatric glioma histone H3.3 K27M/G34R mutations drive
            abnormalities in PML nuclear bodies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   Aldera,A.P. and Govender,D.
  TITLE     Gene of the month: H3F3A and H3F3B
  JOURNAL   J Clin Pathol 75 (1), 1-4 (2022)
   PUBMED   34782425
  REMARK    GeneRIF: Gene of the month: H3F3A and H3F3B.
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Okur,V., Chen,Z., Vossaert,L., Peacock,S., Rosenfeld,J., Zhao,L.,
            Du,H., Calamaro,E., Gerard,A., Zhao,S., Kelsay,J., Lahr,A.,
            Mighton,C., Porter,H.M., Siemon,A., Silver,J., Svihovec,S.,
            Fong,C.T., Grant,C.L., Lerner-Ellis,J., Manickam,K.,
            Madan-Khetarpal,S., McCandless,S.E., Morel,C.F., Schaefer,G.B.,
            Berry-Kravis,E.M., Gates,R., Gomez-Ospina,N., Qiu,G., Zhang,T.J.,
            Wu,Z., Meng,L., Liu,P., Scott,D.A., Lupski,J.R., Eng,C.M., Wu,N.
            and Yuan,B.
  TITLE     De novo variants in H3-3A and H3-3B are associated with
            neurodevelopmental delay, dysmorphic features, and structural brain
            abnormalities
  JOURNAL   NPJ Genom Med 6 (1), 104 (2021)
   PUBMED   34876591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Witt,O., Albig,W. and Doenecke,D.
  TITLE     Transcriptional regulation of the human replacement histone gene
            H3.3B
  JOURNAL   FEBS Lett 408 (3), 255-260 (1997)
   PUBMED   9188772
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Albig,W., Bramlage,B., Gruber,K., Klobeck,H.G., Kunz,J. and
            Doenecke,D.
  TITLE     The human replacement histone H3.3B gene (H3F3B)
  JOURNAL   Genomics 30 (2), 264-272 (1995)
   PUBMED   8586426
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   Akhmanova,A.S., Bindels,P.C., Xu,J., Miedema,K., Kremer,H. and
            Hennig,W.
  TITLE     Structure and expression of histone H3.3 genes in Drosophila
            melanogaster and Drosophila hydei
  JOURNAL   Genome 38 (3), 586-600 (1995)
   PUBMED   7557364
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Bryant,L. and Bhoj,E.
  TITLE     Bryant-Li-Bhoj Neurodevelopmental Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37782742
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   Fretzin,S., Allan,B.D., van Daal,A. and Elgin,S.C.
  TITLE     A Drosophila melanogaster H3.3 cDNA encodes a histone variant
            identical with the vertebrate H3.3
  JOURNAL   Gene 107 (2), 341-342 (1991)
   PUBMED   1748304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087289.9.
            
            On Nov 23, 2018 this sequence version replaced NM_005324.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene contains introns and its mRNA is
            polyadenylated, unlike most histone genes. The protein encoded by
            this gene is a replication-independent histone that is a member of
            the histone H3 family. Pseudogenes of this gene have been
            identified on the X chromosome, and on chromosomes 5, 13 and 17.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537379.1, AK130772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000254810.8/
                                               ENSP00000254810.3
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression,
                                               longest protein
            replication-independent histone :: PMID: 8586426
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC087289.9         173608-173730
            124-261             AC087289.9         174203-174340
            262-415             AC087289.9         174424-174577
            416-2705            AC087289.9         174664-176953
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2705
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="H3.3 histone B"
                     /db_xref="GeneID:3021"
                     /db_xref="HGNC:HGNC:4765"
                     /db_xref="MIM:601058"
     exon            1..123
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /inference="alignment:Splign:2.1.0"
     exon            124..261
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..544
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="H3 histone, family 3B (H3.3B); H3 histone family
                     member 3B"
                     /codon_start=1
                     /product="histone H3.3"
                     /protein_id="NP_005315.1"
                     /db_xref="CCDS:CCDS11729.1"
                     /db_xref="GeneID:3021"
                     /db_xref="HGNC:HGNC:4765"
                     /db_xref="MIM:601058"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     exon            262..415
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /inference="alignment:Splign:2.1.0"
     exon            416..2705
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="hexamer: AATAAA"
     polyA_site      889
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="major polyA site"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="hexamer: AATAAA"
     polyA_site      1680
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="major polyA site"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="H3-3B"
                     /gene_synonym="BRYLIB2; H3-3A; H3.3B; H3F3B"
ORIGIN      
        1 gagcgcagag cggtttggtc gttcgttggg cggtgctggt ttttcgctcg tcgactgcgg
       61 ctcttcctcg ggcagcggaa gcggcgcggc ggtcggagaa gtggcctaaa acttcggcgt
      121 tgggtgaaag aaaatggccc gaaccaagca gactgctcgt aagtccaccg gtgggaaagc
      181 cccccgcaaa cagctggcca cgaaagccgc caggaaaagc gctccctcta ccggcggggt
      241 gaagaagcct catcgctaca ggcccgggac cgtggcgctt cgagagattc gtcgttatca
      301 gaagtcgacc gagctgctca tccggaagct gcccttccag aggttggtga gggagatcgc
      361 gcaggatttc aaaaccgacc tgaggtttca gagcgcagcc atcggtgcgc tgcaggaggc
      421 tagcgaagcg tacctggtgg gtctgttcga agataccaac ctgtgtgcca tccacgctaa
      481 gagagtcacc atcatgccca aagacatcca gttggctcgc cggatacggg gagagagagc
      541 ttaagtgaag gcagttttta tggcgttttg tagtaaattc tgtaaaatac tttggtttaa
      601 tttgtgactt tttttgtaag aaattgttta taatatgttg catttgtact taagtcattc
      661 catctttcac tcaggatgaa tgcgaaaagt gactgttcac agacctcagt gatgtgagca
      721 ctgttgctca ggagtgacaa gttgctaata tgcagaaggg atgggtgata cttcttgctt
      781 ctcatgatgc atgtttctgt atgttaatga cttgttgggt agctattaag gtactagagt
      841 tgataaatgt gtacagggtc cttttgcaat aaaactggtt atgacttgat ccaagtgttt
      901 aacaattggg gctgttaagt ctgaccatac atcactgtga tagaatgtgg gctttttcaa
      961 gggtgaagat acaagtctta accacagtgt aacttacagt ttcctttaaa aaaaaaaaaa
     1021 gtaaacctgg cagctataga atacactatg tgcatttata atagctattt tatatattgt
     1081 agtatcaaca tttttaaatt aaatgtttta cattcacaag tggtggggag tcttgtcatt
     1141 aaggtgtgtg taatttagag tccagttggt tttcttctga ctgcacttgt tctcatagta
     1201 gtaaaatgct atgcgcattt ataccttgca taagtcctca ttctaccaca tgttaaccct
     1261 ctagctgata atgcaaacac taactggggg attttattta taagggctct agaaaaaacg
     1321 agttattcac accagcatca tcttaactaa cattctgaac tagttagtgc agcttttcat
     1381 tgtgttgtgt ggttggtctc ataactaggt tgagtttttc tcctctgctg aggaaacagt
     1441 accgaagttc tttttcttgt ggcatttgta ttataaaaac ttggtgtggg ggaggagcac
     1501 aaaactccag cccactgaac ctctgccaat taagatggtg ttgggttagg ttacatctgg
     1561 ttactgtcct gggaaaatca tttttataga gatggccttc caagtggttt taaaatttac
     1621 tgaagttttt aggtcaatta tgtatgttga ctaaatttac aaataaactt gtttatccaa
     1681 ctaagtgtcc aaaacctaaa ttgaatgtac taagttttca catgtcccat tatctaggtc
     1741 cttgtatact aatgttttga acttagatca tttcaggtgt tgtttggtgg ataaaggaac
     1801 cttttattta taaagatact gtagaaagca tgtgaacagc tctctgcttg attaagatgc
     1861 cataatagtg ctgtatttgc agtgtgggct aagacaaagt atattaataa gcttttcagc
     1921 ccccccactc ccgttccgta gtgtagaagc ccacaggtgt agaactcagt cttaaacttc
     1981 agtatgaaac cagtttcctt gtgcgatgat ggccactaaa gcatagtacg tggatgtcag
     2041 tgagacagca tgagagccag cagtcatcaa agcgttccac gtttgaagtt agcaactgct
     2101 taaagttata ccccattaaa attgctttct caaaagtttg ggttagtttc aaatgtgata
     2161 ttttggaggg aaggtaaagt aggtatcttt caggtcgtga taatgagctc ctatgaaagg
     2221 atgcaatata atgacccgct tttctagaaa gttcataatc agctctggaa caagcacact
     2281 tgattcctca ctgtgcttca gaatgagatt aagatcagat gttggaacgt gctatgctgt
     2341 agcgtgtctg gaaacaaagt acacaaacct ggctacggtg atgagttagc ttctgcttac
     2401 tacctgtgac aacccaagtg ggtgacacta gtgaaccttc tccagtctgc aggctggcat
     2461 agaaggctct tagattatat tgggcagctt gcaatctgcc gaagcagtga cttgcatttc
     2521 cacacttggc ttgagcactc aacccagaag gcgaagatag cttttggttg taggcggctt
     2581 cctgtatggg atatccctcg gtaagggtaa aggagcagag gcaaaggaga aaagcagaag
     2641 ttgcagctga tgcaggtatc ctatgccctt gatggatgag actaaaataa aatttttgaa
     2701 gttaa
//
