LOCUS       NM_002107               1070 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens H3.3 histone A (H3-3A), transcript variant 1, mRNA.
ACCESSION   NM_002107
VERSION     NM_002107.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Voon,H.P.J., Hii,L., Garvie,A., Udugama,M., Krug,B., Russo,C.,
            Chueh,A.C., Daly,R.J., Morey,A., Bell,T.D.M., Turner,S.J.,
            Rosenbluh,J., Daniel,P., Firestein,R., Mann,J.R., Collas,P.,
            Jabado,N. and Wong,L.H.
  TITLE     Pediatric glioma histone H3.3 K27M/G34R mutations drive
            abnormalities in PML nuclear bodies
  JOURNAL   Genome Biol 24 (1), 284 (2023)
   PUBMED   38066546
  REMARK    GeneRIF: Pediatric glioma histone H3.3 K27M/G34R mutations drive
            abnormalities in PML nuclear bodies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Karthik,N., Lee,J.J.H., Soon,J.L.J., Chiu,H.Y., Loh,A.H.P.,
            Ong,D.S.T., Tam,W.L. and Taneja,R.
  TITLE     Histone variant H3.3 promotes metastasis in alveolar
            rhabdomyosarcoma
  JOURNAL   J Pathol 259 (3), 342-356 (2023)
   PUBMED   36573560
  REMARK    GeneRIF: Histone variant H3.3 promotes metastasis in alveolar
            rhabdomyosarcoma.
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Zhao,Y., Chen,Y., Wang,L., Gao,Y. and Xu,J.
  TITLE     The clinicopathological features and prognosis of multifocal
            high-grade gliomas in adults with H3F3A mutation
  JOURNAL   Neurosciences (Riyadh) 28 (1), 42-47 (2023)
   PUBMED   36617452
  REMARK    GeneRIF: The clinicopathological features and prognosis of
            multifocal high-grade gliomas in adults with H3F3A mutation.
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Albig,W., Bramlage,B., Gruber,K., Klobeck,H.G., Kunz,J. and
            Doenecke,D.
  TITLE     The human replacement histone H3.3B gene (H3F3B)
  JOURNAL   Genomics 30 (2), 264-272 (1995)
   PUBMED   8586426
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Bryant,L. and Bhoj,E.
  TITLE     Bryant-Li-Bhoj Neurodevelopmental Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37782742
REFERENCE   8  (bases 1 to 1070)
  AUTHORS   Wells,D., Hoffman,D. and Kedes,L.
  TITLE     Unusual structure, evolutionary conservation of non-coding
            sequences and numerous pseudogenes characterize the human H3.3
            histone multigene family
  JOURNAL   Nucleic Acids Res 15 (7), 2871-2889 (1987)
   PUBMED   3031613
REFERENCE   9  (bases 1 to 1070)
  AUTHORS   Wells,D. and Kedes,L.
  TITLE     Structure of a human histone cDNA: evidence that basally expressed
            histone genes have intervening sequences and encode
            polyadenylylated mRNAs
  JOURNAL   Proc Natl Acad Sci U S A 82 (9), 2834-2838 (1985)
   PUBMED   2859593
REFERENCE   10 (bases 1 to 1070)
  AUTHORS   Ohe,Y. and Iwai,K.
  TITLE     Human spleen histone H3. Isolation and amino acid sequence
  JOURNAL   J Biochem 90 (4), 1205-1211 (1981)
   PUBMED   7309716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512343.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 3, 2019 this sequence version replaced NM_002107.6.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene contains introns and its mRNA is
            polyadenylated, unlike most histone genes. The protein encoded is a
            replication-independent member of the histone H3 family. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD048246.1, BM785212.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000366815.10/
                                               ENSP00000355780.3
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression,
                                               longest protein
            replication-independent histone :: PMID: 8586426
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AL512343.21        37970-38065
            97-247              AL512343.21        39583-39733
            248-401             AL512343.21        40910-41063
            402-1070            AL512343.21        46605-47273
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..1070
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="H3.3 histone A"
                     /db_xref="GeneID:3020"
                     /db_xref="HGNC:HGNC:4764"
                     /db_xref="MIM:601128"
     exon            1..96
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /inference="alignment:Splign:2.1.0"
     exon            97..247
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..530
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="H3 histone, family 3A; H3 histone family member 3A"
                     /codon_start=1
                     /product="histone H3.3"
                     /protein_id="NP_002098.1"
                     /db_xref="CCDS:CCDS1550.1"
                     /db_xref="GeneID:3020"
                     /db_xref="HGNC:HGNC:4764"
                     /db_xref="MIM:601128"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     exon            248..401
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /inference="alignment:Splign:2.1.0"
     exon            402..1070
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1033..1038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="hexamer: ATTAAA"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="hexamer: ATTAAA"
     polyA_site      1058
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="major polyA site"
     polyA_site      1070
                     /gene="H3-3A"
                     /gene_synonym="BRYLIB1; H3-3B; H3.3A; H3F3; H3F3A"
                     /note="major polyA site"
ORIGIN      
        1 ctttcaattg tgttcgcagc cgccgccgcg ccgccgtcgc tctccaacgc cagcgccgcc
       61 tctcgctcgc cgagctccag ccgaaggaga aggggggtaa gtaaggaggt ctctgtacca
      121 tggctcgtac aaagcagact gcccgcaaat cgaccggtgg taaagcaccc aggaagcaac
      181 tggctacaaa agccgctcgc aagagtgcgc cctctactgg aggggtgaag aaacctcatc
      241 gttacaggcc tggtactgtg gcgctccgtg aaattagacg ttatcagaag tccactgaac
      301 ttctgattcg caaacttccc ttccagcgtc tggtgcgaga aattgctcag gactttaaaa
      361 cagatctgcg cttccagagc gcagctatcg gtgctttgca ggaggcaagt gaggcctatc
      421 tggttggcct ttttgaagac accaacctgt gtgctatcca tgccaaacgt gtaacaatta
      481 tgccaaaaga catccagcta gcacgccgca tacgtggaga acgtgcttaa gaatccacta
      541 tgatgggaaa catttcattc tcaaaaaaaa aaaaaaaaat ttctcttctt cctgttattg
      601 gtagttctga acgttagata ttttttttcc atggggtcaa aaggtaccta agtatatgat
      661 tgcgagtgga aaaatagggg acagaaatca ggtattggca gtttttccat tttcatttgt
      721 gtgtgaattt ttaatataaa tgcggagacg taaagcatta atgcaagtta aaatgtttca
      781 gtgaacaagt ttcagcggtt caactttata ataattataa ataaacctgt taaatttttc
      841 tggacaatgc cagcatttgg atttttttaa aacaagtaaa tttcttattg atggcaacta
      901 aatggtgttt gtagcatttt tatcatacag tagattccat ccattcacta tacttttcta
      961 actgagttgt cctacatgca agtacatgtt tttaatgttg tctgtcttct gtgctgttcc
     1021 tgtaagtttg ctattaaaat acattaaact atacctgctt ttggtcttta
//
