LOCUS       NM_001388464             870 bp    mRNA    linear   PRI 04-JAN-2024
DEFINITION  Homo sapiens H2B.W histone 2 (H2BW2), transcript variant 3, mRNA.
ACCESSION   NM_001388464
VERSION     NM_001388464.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Molaro A and Drinnenberg IA.
  TITLE     Studying the Evolution of Histone Variants Using Phylogeny
  JOURNAL   Methods Mol Biol 1832, 273-291 (2018)
   PUBMED   30073533
REFERENCE   2  (bases 1 to 870)
  AUTHORS   El Kennani S, Adrait A, Shaytan AK, Khochbin S, Bruley C, Panchenko
            AR, Landsman D, Pflieger D and Govin J.
  TITLE     MS_HistoneDB, a manually curated resource for proteomic analysis of
            human and mouse histones
  JOURNAL   Epigenetics Chromatin 10, 2 (2017)
   PUBMED   28096900
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Talbert PB, Ahmad K, Almouzni G, Ausio J, Berger F, Bhalla PL,
            Bonner WM, Cande WZ, Chadwick BP, Chan SW, Cross GA, Cui L,
            Dimitrov SI, Doenecke D, Eirin-Lopez JM, Gorovsky MA, Hake SB,
            Hamkalo BA, Holec S, Jacobsen SE, Kamieniarz K, Khochbin S,
            Ladurner AG, Landsman D, Latham JA, Loppin B, Malik HS, Marzluff
            WF, Pehrson JR, Postberg J, Schneider R, Singh MB, Smith MM,
            Thompson E, Torres-Padilla ME, Tremethick DJ, Turner BM, Waterborg
            JH, Wollmann H, Yelagandula R, Zhu B and Henikoff S.
  TITLE     A unified phylogeny-based nomenclature for histone variants
  JOURNAL   Epigenetics Chromatin 5, 7 (2012)
   PUBMED   22650316
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D,
            Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL,
            Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles
            ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman
            R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P,
            Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E,
            Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA,
            Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A,
            Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM,
            Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N,
            Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford
            EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J,
            Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E,
            Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke
            G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V,
            Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis
            C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H,
            Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ,
            Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL,
            Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert
            J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock
            R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD,
            Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M,
            Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob
            L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S,
            Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A,
            Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L,
            Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD,
            Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall
            J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G,
            Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N,
            Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R,
            Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM,
            Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S,
            Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C,
            Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC,
            Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor
            PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K,
            Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana
            D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A,
            Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G,
            Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL,
            Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D,
            Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ,
            Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M,
            Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T,
            Gibbs RA, Beck S, Rogers J and Bentley DR.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234782.5.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-independent histone
            that is a member of the H2B histone family. [provided by RefSeq,
            Nov 2015].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000675318.3/
                                                ENSP00000502072.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            replication-independent histone  :: PMID: 22650316
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC234782.5         176372-176820
            450-508             AC234782.5         177244-177302
            509-527             AC234782.5         177504-177522
            528-870             AC234782.5         178528-178870
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..870
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /note="H2B.W histone 2"
                     /db_xref="GeneID:286436"
                     /db_xref="HGNC:HGNC:27867"
     exon            1..449
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..486
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /note="histone H2B.s; H2B histone family member M; H2B.M
                     histone"
                     /codon_start=1
                     /product="histone H2B type F-M"
                     /protein_id="NP_001375393.1"
                     /db_xref="CCDS:CCDS55468.2"
                     /db_xref="GeneID:286436"
                     /db_xref="HGNC:HGNC:27867"
                     /translation="MAEASSETTSEEGQSIQEPKEANSTKAQKQKRRGCRGSRRRHAN
                     RRGDSFGDSFTPYFPRVLKQVHQGLSLSQEAVSVMDSMIHDILDRIATEAGQLAHYTK
                     RVTITSRDIQMAVRLLLPGKMGKLAEAQGTNAALRTSLCAIWQQRK"
     exon            450..508
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /inference="alignment:Splign:2.1.0"
     exon            509..527
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /inference="alignment:Splign:2.1.0"
     exon            528..870
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      845..850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="H2BW2"
                     /gene_synonym="H2B/s; H2BFM; H2BM"
                     /note="major polyA site"
ORIGIN      
        1 actctctgtt cttgctatct aatggccgct gcttccgcca tggctgaggc ttcctctgag
       61 acaacctcgg aggaaggcca gagcatccag gagcccaaag aggccaactc cacgaaggcc
      121 cagaagcaga agaggcgagg gtgccgaggc tcccgcaggc gccacgccaa ccgccgtggg
      181 gacagcttcg gggacagctt caccccctat ttcccccggg tgctgaagca ggttcaccag
      241 ggcctcagcc tttcccagga ggccgtgagt gtcatggatt ctatgatcca tgacatattg
      301 gaccgcatcg ccaccgaggc tggtcagctg gcccattaca ccaagcgcgt gaccatcacc
      361 tcccgggaca tccagatggc cgtgcgactg ctgctgccgg ggaagatggg caagctcgcc
      421 gaggcccagg gcacgaatgc cgccctcaga acttcattat gtgcgatatg gcaacagaga
      481 aagtgaatat gctgatacaa gaagcaagaa accttcctta cttccagatt attagaaaaa
      541 tattacagaa atagctgaag agaaatgtta tgaaaatagt tgaagttgtg cttattgcac
      601 gaggagacca agaaaaaccc cacaaaatca gctgcaagta aatccttctg gatggtgcca
      661 ccaaatgttc ctacaagtcc ggaacaaccc ttgccaaacc aaagaccctt gccagaaccc
      721 tgcttcttcc cagagacaga gctgtgtacc tgacaaaaca ccacatctca ctcagtgact
      781 tatttctcat tatgctaatt gttttgctgt aaaatgccaa tgtttctgtg aattaagaca
      841 tacgaataaa tttctgaagt tacccttgca
//
