LOCUS       NM_001002916             915 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens H2B.W histone 1 (H2BW1), mRNA.
ACCESSION   NM_001002916 XM_088735
VERSION     NM_001002916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 915)
  AUTHORS   Amor,H., Juhasz-Boss,I., Bibi,R., Hammadeh,M.E. and Jankowski,P.M.
  TITLE     H2BFWT Variations in Sperm DNA and Its Correlation to Pregnancy
  JOURNAL   Int J Mol Sci 25 (11), 6048 (2024)
   PUBMED   38892236
  REMARK    GeneRIF: H2BFWT Variations in Sperm DNA and Its Correlation to
            Pregnancy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 915)
  AUTHORS   Amor,H., Jankowski,P.M., Dahadhah,F.W., Al Zoubi,M.S. and
            Hammadeh,M.E.
  TITLE     Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2
            genes variants on male infertility
  JOURNAL   Andrologia 54 (11), e14611 (2022)
   PUBMED   36217675
  REMARK    GeneRIF: Impact of tobacco smoking in association with H2BFWT, PRM1
            and PRM2 genes variants on male infertility.
REFERENCE   3  (bases 1 to 915)
  AUTHORS   Amor,H., Zeyad,A. and Hammadeh,M.E.
  TITLE     Tobacco smoking and its impact on the expression level of sperm
            nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2
  JOURNAL   Andrologia 53 (3), e13964 (2021)
   PUBMED   33440036
  REMARK    GeneRIF: Tobacco smoking and its impact on the expression level of
            sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.
REFERENCE   4  (bases 1 to 915)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 915)
  AUTHORS   Teimouri,M., Najaran,H., Hosseinzadeh,A. and Mazoochi,T.
  TITLE     Association between two common transitions of H2BFWT gene and male
            infertility: a case-control, meta, and structural analysis
  JOURNAL   Andrology 6 (2), 306-316 (2018)
   PUBMED   29453813
  REMARK    GeneRIF: the association of -9C>T and 368A>G polymorphisms in
            H2BFWT gene with male infertility risk was assessed through a
            case-control and meta-analysis
REFERENCE   6  (bases 1 to 915)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   7  (bases 1 to 915)
  AUTHORS   Lee,J., Park,H.S., Kim,H.H., Yun,Y.J., Lee,D.R. and Lee,S.
  TITLE     Functional polymorphism in H2BFWT-5'UTR is associated with
            susceptibility to male infertility
  JOURNAL   J Cell Mol Med 13 (8B), 1942-1951 (2009)
   PUBMED   19583817
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 915)
  AUTHORS   Boulard,M., Gautier,T., Mbele,G.O., Gerson,V., Hamiche,A.,
            Angelov,D., Bouvet,P. and Dimitrov,S.
  TITLE     The NH2 tail of the novel histone variant H2BFWT exhibits
            properties distinct from conventional H2B with respect to the
            assembly of mitotic chromosomes
  JOURNAL   Mol Cell Biol 26 (4), 1518-1526 (2006)
   PUBMED   16449661
REFERENCE   9  (bases 1 to 915)
  AUTHORS   Churikov,D., Siino,J., Svetlova,M., Zhang,K., Gineitis,A., Morton
            Bradbury,E. and Zalensky,A.
  TITLE     Novel human testis-specific histone H2B encoded by the interrupted
            gene on the X chromosome
  JOURNAL   Genomics 84 (4), 745-756 (2004)
   PUBMED   15475252
REFERENCE   10 (bases 1 to 915)
  AUTHORS   Churikov,D., Zalenskaya,I.A. and Zalensky,A.O.
  TITLE     Male germline-specific histones in mouse and man
  JOURNAL   Cytogenet Genome Res 105 (2-4), 203-214 (2004)
   PUBMED   15237208
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234782.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 4, 2020 this sequence version replaced NM_001002916.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-independent histone
            that is a member of the H2B histone family that is specifically
            expressed in sperm nuclei. A polymorphism in the 5' UTR of this
            gene is associated with male infertility.[provided by RefSeq, Oct
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038109.2, BI459475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000217926.7/
                                                ENSP00000354723.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            replication-independent histone  :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               AC234782.5         149586-150124       c
            540-598             AC234782.5         149106-149164       c
            599-915             AC234782.5         147563-147879       c
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..915
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /note="H2B.W histone 1"
                     /db_xref="GeneID:158983"
                     /db_xref="HGNC:HGNC:27252"
                     /db_xref="MIM:300507"
     exon            1..539
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..576
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /note="H2B histone family member W, testis specific"
                     /codon_start=1
                     /product="histone H2B type W-T"
                     /protein_id="NP_001002916.4"
                     /db_xref="CCDS:CCDS35362.2"
                     /db_xref="GeneID:158983"
                     /db_xref="HGNC:HGNC:27252"
                     /db_xref="MIM:300507"
                     /translation="MAGPSSETTSEEQLITQEPKEANSTTSQKQSKQRKRGRHGPRRC
                     HSNCRGDSFATYFRRVLKQVHQGLSLSREAVSVMDSLVHDILDRIATEAGHLARSTKR
                     QTITAWETRMAVRLLLPGQMGKLAESEGTKAVLRTSLYAIQQQRK"
     exon            540..598
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /inference="alignment:Splign:2.1.0"
     exon            599..915
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /inference="alignment:Splign:2.1.0"
     regulatory      898..903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /note="hexamer: AATAAA"
     polyA_site      915
                     /gene="H2BW1"
                     /gene_synonym="H2BFWT; TH2B-175"
                     /note="major polyA site"
ORIGIN      
        1 gtgacacttc atccaatcag acgtgaagct ggcccgagac gtggagccat gctgcgtacc
       61 gaagtgcccc ggcttccccg gtccacaacc gccattgtct ggtcgtgcca tctaatggcc
      121 actgcctccg ccatggctgg accttcctct gagacgacct ctgaggaaca gctgatcacc
      181 caggagccca aagaggccaa ctccactacg tcccagaagc agagcaagca gaggaagcga
      241 gggcgccatg ggccccgcag gtgccactcc aactgccgcg gggacagctt cgccacctat
      301 ttccgccggg tgctgaagca ggttcaccag ggcctcagcc tttcccggga ggccgtgagt
      361 gtcatggatt ctttggttca tgacatattg gaccgcatcg ccaccgaggc tggtcacctg
      421 gcccgctcca ccaagcgcca gaccatcact gcctgggaga cccggatggc tgtgcgcctg
      481 ctgctgccgg ggcagatggg caagctcgcc gagtccgaag gcacgaaggc tgtcctcaga
      541 acttcactgt atgccataca gcaacagaga aagtgaatac gctgatacaa gaagcaagaa
      601 tattagaaaa atgtcatgaa aatagttgaa gagaaatgct cactgcacaa ggagaccaag
      661 aaaaaccccc cacgaaatca gccacaacta aatcgctctg gacggtgccg ccaggtgacc
      721 ctacatgtcc ggagcaacac tttgaaaacc aaagacgctt ggcagaaccc tgttcctttc
      781 cagagacaga gctgtgtacc ttgtctaaaa caccgcatct cactcagtga cttatttctc
      841 attatgctaa ttgttttcgc tttaaagcgc cagtctttct gtcaaatggg acatacaaat
      901 aaatttctaa aatta
//
