LOCUS       NM_001369125             573 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B.K variant histone 1 (H2BK1), mRNA.
ACCESSION   NM_001369125
VERSION     NM_001369125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   Raman,P., Rominger,M.C., Young,J.M., Molaro,A., Tsukiyama,T. and
            Malik,H.S.
  TITLE     Novel Classes and Evolutionary Turnover of Histone H2B Variants in
            the Mammalian Germline
  JOURNAL   Mol Biol Evol 39 (2) (2022)
   PUBMED   35099534
REFERENCE   2  (bases 1 to 573)
  AUTHORS   Mudge,J.M., Jungreis,I., Hunt,T., Gonzalez,J.M., Wright,J.C.,
            Kay,M., Davidson,C., Fitzgerald,S., Seal,R., Tweedie,S., He,L.,
            Waterhouse,R.M., Li,Y., Bruford,E., Choudhary,J.S., Frankish,A. and
            Kellis,M.
  TITLE     Discovery of high-confidence human protein-coding genes and exons
            by whole-genome PhyloCSF helps elucidate 118 GWAS loci
  JOURNAL   Genome Res 29 (12), 2073-2087 (2019)
   PUBMED   31537640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021097.5.
            
            On Nov 17, 2020 this sequence version replaced NM_001369125.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN02400289
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000644661.2/
                                                ENSP00000495192.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC021097.5         30907-31208
            303-573             AC021097.5         33288-33558
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..573
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /note="H2B.K variant histone 1"
                     /db_xref="GeneID:114483833"
                     /db_xref="HGNC:HGNC:53833"
     exon            1..302
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..539
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /note="novel histone H2B-like protein; histone H2B type
                     2-E1; H2B.E variant histone 1"
                     /codon_start=1
                     /product="histone H2B type 2-K1"
                     /protein_id="NP_001356054.2"
                     /db_xref="CCDS:CCDS94232.1"
                     /db_xref="GeneID:114483833"
                     /db_xref="HGNC:HGNC:53833"
                     /translation="MSAEYGQRQQPGGRGGRSSGNKKSKKRCRRKESYSMYIYKVLKQ
                     VHPDIGISAKAMSIMNSFVNDVFEQLACEAARLAQYSGRTTLTSREVQTAVRLLLPGE
                     LAKHAVSEGTKAVTKYTSSK"
     exon            303..573
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      556..561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /note="hexamer: AATAAA"
     polyA_site      573
                     /gene="H2BK1"
                     /gene_synonym="H2BE1"
                     /note="major polyA site"
ORIGIN      
        1 aaggttagcc cagagcatgt tcaggattgg gattgagtca cgccccttac ctcccacctg
       61 cccccccccc ccctcccagg tgcatgtccc cagccacacc tggtggggca gctgacttga
      121 taaaaagtag ctccaagggg gtgggtgagg gctattcgag aagcaggagg atgagcgctg
      181 agtatggaca gcggcagcag cccgggggcc gtgggggtcg cagttctggg aacaaaaagt
      241 ccaaaaagcg ctgtcggcgc aaggagtcct actccatgta tatctacaag gtgctgaagc
      301 aggtgcaccc tgacattggc atctctgcca aggccatgag catcatgaac tcgtttgtaa
      361 acgacgtgtt tgagcagctg gcgtgtgagg ctgcccggct ggcccagtac tcgggccgga
      421 ccaccctgac atcccgagaa gtccagacgg ctgtgcgtct gctgctgcct ggggagctgg
      481 ccaagcacgc tgtgtctgag ggcaccaagg ctgtcaccaa gtacaccagc tccaagtgac
      541 ccagggcctg acaaaaataa agggtgaact gtt
//
