LOCUS       NM_003524                462 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 9 (H2BC9), mRNA.
ACCESSION   NM_003524
VERSION     NM_003524.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Zhang,W., Chen,X., Wang,Z., Wang,Q., Feng,J., Wang,D., Wang,Z.,
            Tang,J., Qing,S. and Zhang,Y.
  TITLE     Identification of HIST1H2BH as the hub gene associated with
            multiple myeloma using integrated bioinformatics analysis
  JOURNAL   Hematology 29 (1), 2335421 (2024)
   PUBMED   38568025
  REMARK    GeneRIF: Identification of HIST1H2BH as the hub gene associated
            with multiple myeloma using integrated bioinformatics analysis.
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 462)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 462)
  AUTHORS   Zhang,Y., Mao,D., Roswit,W.T., Jin,X., Patel,A.C., Patel,D.A.,
            Agapov,E., Wang,Z., Tidwell,R.M., Atkinson,J.J., Huang,G.,
            McCarthy,R., Yu,J., Yun,N.E., Paessler,S., Lawson,T.G.,
            Omattage,N.S., Brett,T.J. and Holtzman,M.J.
  TITLE     PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C
            protease to enhance interferon signaling and control viral
            infection
  JOURNAL   Nat Immunol 16 (12), 1215-1227 (2015)
   PUBMED   26479788
REFERENCE   5  (bases 1 to 462)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 462)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 462)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 462)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 462)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 462)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003524.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA374205.1, BC096116.3 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000619466.3/
                                             ENSP00000479169.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AL031777.5         56996-57457
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..462
                     /gene="H2BC9"
                     /gene_synonym="H2B/j; H2BFJ; HIST1H2BH"
                     /note="H2B clustered histone 9"
                     /db_xref="GeneID:8345"
                     /db_xref="HGNC:HGNC:4755"
                     /db_xref="MIM:602806"
     exon            1..462
                     /gene="H2BC9"
                     /gene_synonym="H2B/j; H2BFJ; HIST1H2BH"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..418
                     /gene="H2BC9"
                     /gene_synonym="H2B/j; H2BFJ; HIST1H2BH"
                     /note="H2B histone family, member J; histone 1, H2bh;
                     histone H2B.j; histone cluster 1, H2bh; histone cluster 1
                     H2B family member h"
                     /codon_start=1
                     /product="histone H2B type 1-H"
                     /protein_id="NP_003515.1"
                     /db_xref="CCDS:CCDS4601.1"
                     /db_xref="GeneID:8345"
                     /db_xref="HGNC:HGNC:4755"
                     /db_xref="MIM:602806"
                     /translation="MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 actttggggt gtattcttac tcctttatct tgttgcaatg cctgatccag ctaagtccgc
       61 tcccgccccg aagaagggct ccaagaaggc ggtgaccaag gcgcagaaga aggatggcaa
      121 gaagcgtaaa cgcagccgca aggagagcta ctccgtatac gtttacaagg tgctgaagca
      181 agtccacccc gacaccggca tctcctccaa agccatgggg atcatgaatt cctttgtcaa
      241 cgatatcttc gagcgcatcg ccggcgaggc ttcccgcctg gctcattaca acaagcgttc
      301 gaccatcacc tccagggaga tccagacagc cgtgcgcctg ctgctgcctg gggaactggc
      361 caagcacgcc gtgtccgagg gcactaaggc cgtcaccaag tacaccagct ccaaataaat
      421 ggacgcatgt tcaaacccaa aggctctttt cagagccact ta
//
