LOCUS       NM_003518                489 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens H2B clustered histone 8 (H2BC8), mRNA.
ACCESSION   NM_003518
VERSION     NM_003518.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Budziszewski,G.R., Zhao,Y., Spangler,C.J., Kedziora,K.M.,
            Williams,M.R., Azzam,D.N., Skrajna,A., Koyama,Y., Cesmat,A.P.,
            Simmons,H.C., Arteaga,E.C., Strauss,J.D., Kireev,D. and
            McGinty,R.K.
  TITLE     Multivalent DNA and nucleosome acidic patch interactions specify
            VRK1 mitotic localization and activity
  JOURNAL   Nucleic Acids Res 50 (8), 4355-4371 (2022)
   PUBMED   35390161
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 489)
  AUTHORS   Wilson,M.D., Benlekbir,S., Fradet-Turcotte,A., Sherker,A.,
            Julien,J.P., McEwan,A., Noordermeer,S.M., Sicheri,F.,
            Rubinstein,J.L. and Durocher,D.
  TITLE     The structural basis of modified nucleosome recognition by 53BP1
  JOURNAL   Nature 536 (7614), 100-103 (2016)
   PUBMED   27462807
REFERENCE   4  (bases 1 to 489)
  AUTHORS   Falk,S.J., Guo,L.Y., Sekulic,N., Smoak,E.M., Mani,T., Logsdon,G.A.,
            Gupta,K., Jansen,L.E., Van Duyne,G.D., Vinogradov,S.A.,
            Lampson,M.A. and Black,B.E.
  TITLE     Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at
            the centromere
  JOURNAL   Science 348 (6235), 699-703 (2015)
   PUBMED   25954010
REFERENCE   5  (bases 1 to 489)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 489)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 489)
  AUTHORS   Diaz-Jullien,C., Perez-Estevez,A., Covelo,G. and Freire,M.
  TITLE     Prothymosin alpha binds histones in vitro and shows activity in
            nucleosome assembly assay
  JOURNAL   Biochim Biophys Acta 1296 (2), 219-227 (1996)
   PUBMED   8814229
REFERENCE   8  (bases 1 to 489)
  AUTHORS   Frohm,M., Gunne,H., Bergman,A.C., Agerberth,B., Bergman,T.,
            Boman,A., Liden,S., Jornvall,H. and Boman,H.G.
  TITLE     Biochemical and antibacterial analysis of human wound and blister
            fluid
  JOURNAL   Eur J Biochem 237 (1), 86-92 (1996)
   PUBMED   8620898
REFERENCE   9  (bases 1 to 489)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
REFERENCE   10 (bases 1 to 489)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H2B. Isolation and amino acid sequence
  JOURNAL   J Biochem 85 (2), 615-624 (1979)
   PUBMED   422550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003518.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. The protein has antibacterial and antifungal
            antimicrobial activity. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BP347061.1, DA576768.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000541790.4/
                                                  ENSP00000445633.2
            Protein has antimicrobial activity :: PMID: 12860195
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            replication-dependent histone      :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               AL031777.5         21582-22070         c
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..489
                     /gene="H2BC8"
                     /gene_synonym="dJ221C16.8; H2B.1A; H2B/a; H2BC10; H2BC4;
                     H2BC6; H2BC7; H2BFA; HIST1H2BG"
                     /note="H2B clustered histone 8"
                     /db_xref="GeneID:8339"
                     /db_xref="HGNC:HGNC:4746"
                     /db_xref="MIM:602798"
     exon            1..489
                     /gene="H2BC8"
                     /gene_synonym="dJ221C16.8; H2B.1A; H2B/a; H2BC10; H2BC4;
                     H2BC6; H2BC7; H2BFA; HIST1H2BG"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..426
                     /gene="H2BC8"
                     /gene_synonym="dJ221C16.8; H2B.1A; H2B/a; H2BC10; H2BC4;
                     H2BC6; H2BC7; H2BFA; HIST1H2BG"
                     /note="H2B histone family, member A; histone 1, H2bg;
                     histone H2B.a; histone H2B.1 A; histone cluster 1, H2bg;
                     histone cluster 1 H2B family member g"
                     /codon_start=1
                     /product="histone H2B type 1-C/E/F/G/I"
                     /protein_id="NP_003509.1"
                     /db_xref="CCDS:CCDS4594.1"
                     /db_xref="GeneID:8339"
                     /db_xref="HGNC:HGNC:4746"
                     /db_xref="MIM:602798"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 atttaagtgc gttcattctc actgctgtta ttgttttctg acagcatgcc tgaaccagct
       61 aagtcagctc ctgctccgaa gaagggttcc aagaaggctg tgaccaaggc gcagaagaag
      121 gatggcaaga agcgcaagcg cagtcgtaag gagagctact ccgtgtatgt gtacaaggtg
      181 ctaaaacagg ttcaccccga tactggcatc tcatccaagg ccatgggcat catgaattcc
      241 ttcgttaacg acatcttcga acgcatcgca ggcgaggctt cccgtctggc ccactacaac
      301 aagcgctcga ccattacctc cagggagatc cagaccgccg tgcgtctgct gcttcccgga
      361 gagctggcca agcacgcagt gtccgaaggt accaaggctg tcaccaagta tacaagctcc
      421 aagtaaatgt gtgcttaggt gctttaaaac tcaaaggctc ttttcagagc cactcaagtc
      481 tcacataaa
//
