LOCUS       NM_021063                486 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens H2B clustered histone 5 (H2BC5), transcript variant 1,
            mRNA.
ACCESSION   NM_021063
VERSION     NM_021063.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Patankar,A., Gajbhiye,R., Surve,S. and Parte,P.
  TITLE     Epigenetic landscape of testis specific histone H2B variant and its
            influence on sperm function
  JOURNAL   Clin Epigenetics 13 (1), 101 (2021)
   PUBMED   33933143
  REMARK    GeneRIF: Epigenetic landscape of testis specific histone H2B
            variant and its influence on sperm function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Valencia-Sanchez,M.I., De Ioannes,P., Wang,M., Vasilyev,N.,
            Chen,R., Nudler,E., Armache,J.P. and Armache,K.J.
  TITLE     Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120
            Ubiquitination
  JOURNAL   Mol Cell 74 (5), 1010-1019 (2019)
   PUBMED   30981630
  REMARK    GeneRIF: We report cryo-EM structures of human Dot1L bound to (1)
            H2BK120Ub and (2) unmodified nucleosome substrates at 3.5 A and 4.9
            A, respectively. Comparison of both structures, complemented with
            biochemical experiments, provides critical insights into the
            mechanism of Dot1L stimulation by H2BK120Ub.
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 486)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 486)
  AUTHORS   Lorain,S., Quivy,J.P., Monier-Gavelle,F., Scamps,C., Lecluse,Y.,
            Almouzni,G. and Lipinski,M.
  TITLE     Core histones and HIRIP3, a novel histone-binding protein, directly
            interact with WD repeat protein HIRA
  JOURNAL   Mol Cell Biol 18 (9), 5546-5556 (1998)
   PUBMED   9710638
REFERENCE   7  (bases 1 to 486)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   8  (bases 1 to 486)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 486)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 486)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353759.8.
            
            On Dec 3, 2019 this sequence version replaced NM_021063.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Two transcripts that encode the same protein have been
            identified for this gene, which is found in the large histone gene
            cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) contains a palindromic
            termination sequence instead of a polyA signal and tail. Variants 1
            and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB107614.1, BC096122.3 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000377777.6/
                                             ENSP00000367008.4
            RefSeq Select criteria        :: based on manual assertion,
                                             conservation, longest protein
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               AL353759.8         64503-64988
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..486
                     /gene="H2BC5"
                     /gene_synonym="dJ221C16.6; H2B.1B; H2B/a; H2B/b; H2B/g;
                     H2B/h; H2B/k; H2B/l; H2BFA; H2BFB; H2BFG; H2BFH; H2BFK;
                     H2BFL; HIRIP2; HIST1H2BC; HIST1H2BD; HIST1H2BE; HIST1H2BF;
                     HIST1H2BG; HIST1H2BI"
                     /note="H2B clustered histone 5"
                     /db_xref="GeneID:3017"
                     /db_xref="HGNC:HGNC:4747"
                     /db_xref="MIM:602799"
     exon            1..486
                     /gene="H2BC5"
                     /gene_synonym="dJ221C16.6; H2B.1B; H2B/a; H2B/b; H2B/g;
                     H2B/h; H2B/k; H2B/l; H2BFA; H2BFB; H2BFG; H2BFH; H2BFK;
                     H2BFL; HIRIP2; HIST1H2BC; HIST1H2BD; HIST1H2BE; HIST1H2BF;
                     HIST1H2BG; HIST1H2BI"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..429
                     /gene="H2BC5"
                     /gene_synonym="dJ221C16.6; H2B.1B; H2B/a; H2B/b; H2B/g;
                     H2B/h; H2B/k; H2B/l; H2BFA; H2BFB; H2BFG; H2BFH; H2BFK;
                     H2BFL; HIRIP2; HIST1H2BC; HIST1H2BD; HIST1H2BE; HIST1H2BF;
                     HIST1H2BG; HIST1H2BI"
                     /note="H2B histone family, member B; histone 1, H2bd;
                     histone H2B.b; histone H2B.1 B; HIRA-interacting protein
                     2; histone cluster 1, H2bd; Histone H2B type 1-C/E/F/G/I;
                     Histone H2B.1 A; Histone H2B.a; Histone H2B.g; Histone
                     H2B.h; Histone H2B.k; Histone H2B.l; histone cluster 1 H2B
                     family member d"
                     /codon_start=1
                     /product="histone H2B type 1-D"
                     /protein_id="NP_066407.1"
                     /db_xref="CCDS:CCDS4587.1"
                     /db_xref="GeneID:3017"
                     /db_xref="HGNC:HGNC:4747"
                     /db_xref="MIM:602799"
                     /translation="MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     polyA_site      486
                     /gene="H2BC5"
                     /gene_synonym="dJ221C16.6; H2B.1B; H2B/a; H2B/b; H2B/g;
                     H2B/h; H2B/k; H2B/l; H2BFA; H2BFB; H2BFG; H2BFH; H2BFK;
                     H2BFL; HIRIP2; HIST1H2BC; HIST1H2BD; HIST1H2BE; HIST1H2BF;
                     HIST1H2BG; HIST1H2BI"
                     /note="major polyA site"
ORIGIN      
        1 attattttct caggtgtttg caacagtgtt ctaactatta acgctacgat gcctgaacct
       61 accaagtctg ctcctgcccc aaagaagggc tccaagaagg cggtgactaa ggctcagaag
      121 aaggacggga agaagcgcaa gcgcagccgc aaggagagct attcagtgta tgtgtacaag
      181 gtgctgaagc aggtccatcc cgacaccggc atctcttcca aggcaatggg gatcatgaat
      241 tccttcgtca acgacatctt cgagcgcatc gcaggcgagg cttcccgcct ggcgcattac
      301 aacaagcgct cgaccatcac ctccagggag atccagacgg ccgtgcgcct gctgcttccg
      361 ggggagctgg ccaagcacgc cgtgtcggag ggcaccaagg ccgtcaccaa gtacaccagt
      421 tccaagtaac tttgccaagt aagcatcttt acacctaatc ccaaaggctc ttttaagagc
      481 cacgca
//
