LOCUS       NM_003526                460 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens H2B clustered histone 4 (H2BC4), transcript variant 2,
            mRNA.
ACCESSION   NM_003526
VERSION     NM_003526.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Budziszewski,G.R., Zhao,Y., Spangler,C.J., Kedziora,K.M.,
            Williams,M.R., Azzam,D.N., Skrajna,A., Koyama,Y., Cesmat,A.P.,
            Simmons,H.C., Arteaga,E.C., Strauss,J.D., Kireev,D. and
            McGinty,R.K.
  TITLE     Multivalent DNA and nucleosome acidic patch interactions specify
            VRK1 mitotic localization and activity
  JOURNAL   Nucleic Acids Res 50 (8), 4355-4371 (2022)
   PUBMED   35390161
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 460)
  AUTHORS   Lyons,S.M., Cunningham,C.H., Welch,J.D., Groh,B., Guo,A.Y., Wei,B.,
            Whitfield,M.L., Xiong,Y. and Marzluff,W.F.
  TITLE     A subset of replication-dependent histone mRNAs are expressed as
            polyadenylated RNAs in terminally differentiated tissues
  JOURNAL   Nucleic Acids Res 44 (19), 9190-9205 (2016)
   PUBMED   27402160
REFERENCE   4  (bases 1 to 460)
  AUTHORS   Wilson,M.D., Benlekbir,S., Fradet-Turcotte,A., Sherker,A.,
            Julien,J.P., McEwan,A., Noordermeer,S.M., Sicheri,F.,
            Rubinstein,J.L. and Durocher,D.
  TITLE     The structural basis of modified nucleosome recognition by 53BP1
  JOURNAL   Nature 536 (7614), 100-103 (2016)
   PUBMED   27462807
REFERENCE   5  (bases 1 to 460)
  AUTHORS   Tollin,M., Bergman,P., Svenberg,T., Jornvall,H., Gudmundsson,G.H.
            and Agerberth,B.
  TITLE     Antimicrobial peptides in the first line defence of human colon
            mucosa
  JOURNAL   Peptides 24 (4), 523-530 (2003)
   PUBMED   12860195
  REMARK    GeneRIF: Histone H2B antimicrobial peptides participate in the
            colonic defense against bacteria and fungi.
REFERENCE   6  (bases 1 to 460)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 460)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   8  (bases 1 to 460)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   9  (bases 1 to 460)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 460)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H2B. Isolation and amino acid sequence
  JOURNAL   J Biochem 85 (2), 615-624 (1979)
   PUBMED   422550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003526.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. The protein has antibacterial and antifungal
            antimicrobial activity. The main transcript variant of this gene is
            intronless and encodes a replication-dependent histone that is a
            member of the histone H2B family. This transcript variant lacks a
            polyA tail but instead contains a palindromic termination element.
            This gene is found in the large histone gene cluster on chromosome
            6. [provided by RefSeq, Apr 2020].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA383555.1, DA696398.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000396984.2/
                                                  ENSP00000380180.1
            Protein has antimicrobial activity :: PMID: 12860195
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, longest protein
            replication-dependent histone      :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               U91328.1           17133-17592
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..460
                     /gene="H2BC4"
                     /gene_synonym="dJ221C16.3; H2B.1; H2B/l; H2BC10; H2BC6;
                     H2BC7; H2BC8; H2BFL; HIST1H2BC"
                     /note="H2B clustered histone 4"
                     /db_xref="GeneID:8347"
                     /db_xref="HGNC:HGNC:4757"
                     /db_xref="MIM:602847"
     exon            1..460
                     /gene="H2BC4"
                     /gene_synonym="dJ221C16.3; H2B.1; H2B/l; H2BC10; H2BC6;
                     H2BC7; H2BC8; H2BFL; HIST1H2BC"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..403
                     /gene="H2BC4"
                     /gene_synonym="dJ221C16.3; H2B.1; H2B/l; H2BC10; H2BC6;
                     H2BC7; H2BC8; H2BFL; HIST1H2BC"
                     /note="H2B histone family, member L; histone 1, H2bc;
                     histone cluster 1, H2bc; histone H2B.l; histone H2B.1 A;
                     histone cluster 1 H2B family member c"
                     /codon_start=1
                     /product="histone H2B type 1-C/E/F/G/I"
                     /protein_id="NP_003517.2"
                     /db_xref="CCDS:CCDS4584.1"
                     /db_xref="GeneID:8347"
                     /db_xref="HGNC:HGNC:4757"
                     /db_xref="MIM:602847"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 gacacatttc tggtgtttta agatgcctga gccagccaag tctgctcccg ccccgaagaa
       61 gggctccaag aaggcagtga ccaaagcgca gaagaaagat ggcaagaagc gcaagcgcag
      121 ccgcaaggag agttactctg tgtacgtgta caaggtgctg aaacaggtcc atcccgacac
      181 tggcatctct tccaaggcca tgggcatcat gaattctttc gttaacgaca tatttgagcg
      241 catcgcgggc gaggcttccc gcctggcgca ttacaacaag cgctcgacca tcacctccag
      301 ggagatccag acggccgtgc gcctgctgct tcccggagag ctggccaagc acgccgtgtc
      361 ggagggcacc aaggccgtca ccaagtacac cagctccaag taaacattcc aagtaagcgt
      421 cttaacacct aaccccaaag gctcttttaa gagccaccca
//
