LOCUS       NM_021062                487 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 3 (H2BC3), mRNA.
ACCESSION   NM_021062
VERSION     NM_021062.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Valle,B.L., Rodriguez-Torres,S., Kuhn,E., Diaz-Montes,T.,
            Parrilla-Castellar,E., Lawson,F.P., Folawiyo,O., Ili-Gangas,C.,
            Brebi-Mieville,P., Eshleman,J.R., Herman,J., Shih,I.M.,
            Sidransky,D. and Guerrero-Preston,R.
  TITLE     HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision
            Medicine Biomarkers for Diagnosis and Prognosis of High-grade
            Serous Ovarian Cancer
  JOURNAL   Cancer Prev Res (Phila) 13 (9), 783-794 (2020)
   PUBMED   32581010
  REMARK    GeneRIF: HIST1H2BB and MAGI2 Methylation and Somatic Mutations as
            Precision Medicine Biomarkers for Diagnosis and Prognosis of
            High-grade Serous Ovarian Cancer.
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Wojcik,F., Dann,G.P., Beh,L.Y., Debelouchina,G.T., Hofmann,R. and
            Muir,T.W.
  TITLE     Functional crosstalk between histone H2B ubiquitylation and H2A
            modifications and variants
  JOURNAL   Nat Commun 9 (1), 1394 (2018)
   PUBMED   29643390
  REMARK    GeneRIF: Functional crosstalk between histone H2B ubiquitylation
            and H2A modifications and variants has been uncovered.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Segala,G., Bennesch,M.A., Pandey,D.P., Hulo,N. and Picard,D.
  TITLE     Monoubiquitination of Histone H2B Blocks Eviction of Histone
            Variant H2A.Z from Inducible Enhancers
  JOURNAL   Mol Cell 64 (2), 334-346 (2016)
   PUBMED   27692985
  REMARK    GeneRIF: Monoubiquitination of histone H2B blocks eviction of
            histone variant H2A.Z from inducible enhancers.
REFERENCE   5  (bases 1 to 487)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Kardalinou,E., Eick,S., Albig,W. and Doenecke,D.
  TITLE     Association of a human H1 histone gene with an H2A pseudogene and
            genes encoding H2B.1 and H3.1 histones
  JOURNAL   J Cell Biochem 52 (4), 375-383 (1993)
   PUBMED   8227173
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Albig,W., Kardalinou,E., Drabent,B., Zimmer,A. and Doenecke,D.
  TITLE     Isolation and characterization of two human H1 histone genes within
            clusters of core histone genes
  JOURNAL   Genomics 10 (4), 940-948 (1991)
   PUBMED   1916825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_021062.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC096728.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000615966.2/
                                             ENSP00000482674.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               U91328.1           97346-97832
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..487
                     /gene="H2BC3"
                     /gene_synonym="H2B.1; H2B/f; H2BFF; HIST1H2BB"
                     /note="H2B clustered histone 3"
                     /db_xref="GeneID:3018"
                     /db_xref="HGNC:HGNC:4751"
                     /db_xref="MIM:602803"
     exon            1..487
                     /gene="H2BC3"
                     /gene_synonym="H2B.1; H2B/f; H2BFF; HIST1H2BB"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..437
                     /gene="H2BC3"
                     /gene_synonym="H2B.1; H2B/f; H2BFF; HIST1H2BB"
                     /note="H2B histone family, member F; histone 1, H2bb;
                     histone H2B.1; histone H2B.f; histone cluster 1, H2bb;
                     histone cluster 1 H2B family member b"
                     /codon_start=1
                     /product="histone H2B type 1-B"
                     /protein_id="NP_066406.1"
                     /db_xref="CCDS:CCDS4575.1"
                     /db_xref="GeneID:3018"
                     /db_xref="HGNC:HGNC:4751"
                     /db_xref="MIM:602803"
                     /translation="MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 gtactactct gtagtggaga gtgttagtag cttttctatt ctgtttagga atagcaatgc
       61 ctgaaccctc taagtctgct ccagccccta aaaagggttc taagaaggct atcactaagg
      121 cgcagaagaa ggatggtaag aagcgtaagc gcagccgcaa ggagagctat tctatctatg
      181 tgtacaaggt tctgaagcag gtccaccccg acaccggcat ctcatccaag gccatgggga
      241 tcatgaattc cttcgtcaac gacatcttcg agcgcatcgc gggcgaggct tctcgcctgg
      301 ctcactacaa taagcgctcg accatcacct ccagggagat tcagacggct gtgcgcctgc
      361 tgctgcctgg ggagctggct aagcatgctg tgtccgaggg cactaaggca gttaccaagt
      421 acactagctc taaataagtg cttatgtaag cacttccaaa cccaaaggct cttttcagag
      481 ccaccta
//
