LOCUS       NM_175055                456 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 26 (H2BC26), mRNA.
ACCESSION   NM_175055
VERSION     NM_175055.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Moyal,L., Lerenthal,Y., Gana-Weisz,M., Mass,G., So,S., Wang,S.Y.,
            Eppink,B., Chung,Y.M., Shalev,G., Shema,E., Shkedy,D.,
            Smorodinsky,N.I., van Vliet,N., Kuster,B., Mann,M., Ciechanover,A.,
            Dahm-Daphi,J., Kanaar,R., Hu,M.C., Chen,D.J., Oren,M. and Shiloh,Y.
  TITLE     Requirement of ATM-dependent monoubiquitylation of histone H2B for
            timely repair of DNA double-strand breaks
  JOURNAL   Mol Cell 41 (5), 529-542 (2011)
   PUBMED   21362549
  REMARK    GeneRIF: ATM-dependent monoubiquitylation of histone H2B is
            required for timely repair of DNA double-strand breaks
REFERENCE   3  (bases 1 to 456)
  AUTHORS   Kobiyama,K., Takeshita,F., Jounai,N., Sakaue-Sawano,A.,
            Miyawaki,A., Ishii,K.J., Kawai,T., Sasaki,S., Hirano,H., Ishii,N.,
            Okuda,K. and Suzuki,K.
  TITLE     Extrachromosomal histone H2B mediates innate antiviral immune
            responses induced by intracellular double-stranded DNA
  JOURNAL   J Virol 84 (2), 822-832 (2010)
   PUBMED   19906922
  REMARK    GeneRIF: The present findings provide evidence indicating that the
            extrachromosomal histone H2B is engaged in the signaling pathway
            initiated by dsDNA to trigger antiviral innate immune responses.
REFERENCE   4  (bases 1 to 456)
  AUTHORS   Sarkari,F., Sanchez-Alcaraz,T., Wang,S., Holowaty,M.N., Sheng,Y.
            and Frappier,L.
  TITLE     EBNA1-mediated recruitment of a histone H2B deubiquitylating
            complex to the Epstein-Barr virus latent origin of DNA replication
  JOURNAL   PLoS Pathog 5 (10), e1000624 (2009)
   PUBMED   19834552
  REMARK    GeneRIF: USP7 can stimulate EBNA1-DNA interactions and EBNA1 can
            alter histone modification at oriP through recruitment of USP7.
REFERENCE   5  (bases 1 to 456)
  AUTHORS   Zini,A., Zhang,X. and San Gabriel,M.
  TITLE     Sperm nuclear histone H2B: correlation with sperm DNA denaturation
            and DNA stainability
  JOURNAL   Asian J Androl 10 (6), 865-871 (2008)
   PUBMED   18958350
  REMARK    GeneRIF: infertile men have a higher proportion of spermatozoa with
            diffuse histone H2B
REFERENCE   6  (bases 1 to 456)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 456)
  AUTHORS   Deng,L., Wang,D., de la Fuente,C., Wang,L., Li,H., Lee,C.G.,
            Donnelly,R., Wade,J.D., Lambert,P. and Kashanchi,F.
  TITLE     Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
  JOURNAL   Virology 289 (2), 312-326 (2001)
   PUBMED   11689053
REFERENCE   8  (bases 1 to 456)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   9  (bases 1 to 456)
  AUTHORS   Thomson,S., Clayton,A.L., Hazzalin,C.A., Rose,S., Barratt,M.J. and
            Mahadevan,L.C.
  TITLE     The nucleosomal response associated with immediate-early gene
            induction is mediated via alternative MAP kinase cascades: MSK1 as
            a potential histone H3/HMG-14 kinase
  JOURNAL   EMBO J 18 (17), 4779-4793 (1999)
   PUBMED   10469656
REFERENCE   10 (bases 1 to 456)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139288.15.
            
            On Dec 3, 2019 this sequence version replaced NM_175055.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene contain a palindromic
            termination element. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA770614.1, DA789979.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000693095.1/
                                             ENSP00000509901.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AL139288.15        99807-100262        c
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..456
                     /gene="H2BC26"
                     /gene_synonym="H2Bb; H2BU1; HIST3H2BB"
                     /note="H2B clustered histone 26"
                     /db_xref="GeneID:128312"
                     /db_xref="HGNC:HGNC:20514"
                     /db_xref="MIM:615046"
     exon            1..456
                     /gene="H2BC26"
                     /gene_synonym="H2Bb; H2BU1; HIST3H2BB"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..408
                     /gene="H2BC26"
                     /gene_synonym="H2Bb; H2BU1; HIST3H2BB"
                     /note="histone 3, H2bb; histone cluster 3 H2B family
                     member b; histone cluster 3, H2bb; H2B type 12; H2B.U
                     histone 1"
                     /codon_start=1
                     /product="histone H2B type 3-B"
                     /protein_id="NP_778225.1"
                     /db_xref="CCDS:CCDS1574.1"
                     /db_xref="GeneID:128312"
                     /db_xref="HGNC:HGNC:20514"
                     /db_xref="MIM:615046"
                     /translation="MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 gtttctgttt ggagagactc agccatcatg ccagacccgt ccaaatcggc tcctgcgccc
       61 aagaagggtt ctaaaaaggc tgtcaccaag gcacagaaga aggacggcaa gaagcgcaag
      121 cgcggccgca aggagagcta ttctatctac gtgtacaagg tgctgaagca ggtgcacccc
      181 gacaccggca tctcgtccaa ggccatgggc atcatgaact ccttcgtcaa tgacatcttc
      241 gagcgcatcg ccagcgaggc ctcccgcctg gcacactaca acaagcgctc caccatcacg
      301 tcccgcgaag tgcagacggc cgttcgcctg ctgctgcccg gcgagctggc caagcacgcc
      361 gtgtccgagg gcaccaaggc tgtcaccaag tacaccagct ccaagtgagg cgttcctcgg
      421 cgtcctgaac ccaaaggctc ttttcagagc caccca
//
