LOCUS       NM_001024599             492 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 18 (H2BC18), transcript variant
            1, mRNA.
ACCESSION   NM_001024599 XM_496411
VERSION     NM_001024599.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 492)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   6  (bases 1 to 492)
  AUTHORS   Bonenfant,D., Coulot,M., Towbin,H., Schindler,P. and van Oostrum,J.
  TITLE     Characterization of histone H2A and H2B variants and their
            post-translational modifications by mass spectrometry
  JOURNAL   Mol Cell Proteomics 5 (3), 541-552 (2006)
   PUBMED   16319397
REFERENCE   7  (bases 1 to 492)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   8  (bases 1 to 492)
  AUTHORS   Golebiowski,F. and Kasprzak,K.S.
  TITLE     Inhibition of core histones acetylation by carcinogenic nickel(II)
  JOURNAL   Mol Cell Biochem 279 (1-2), 133-139 (2005)
   PUBMED   16283522
REFERENCE   9  (bases 1 to 492)
  AUTHORS   Cheung,W.L., Ajiro,K., Samejima,K., Kloc,M., Cheung,P.,
            Mizzen,C.A., Beeser,A., Etkin,L.D., Chernoff,J., Earnshaw,W.C. and
            Allis,C.D.
  TITLE     Apoptotic phosphorylation of histone H2B is mediated by mammalian
            sterile twenty kinase
  JOURNAL   Cell 113 (4), 507-517 (2003)
   PUBMED   12757711
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239868.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 3, 2019 this sequence version replaced NM_001024599.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene encodes a
            replication-dependent histone that is a member of the histone H2B
            family and is found in a histone cluster on chromosome 1. [provided
            by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) differs in the 3' coding
            region and 3' UTR, compared to variant 2. The encoded isoform (a)
            has a shorter C-terminus compared to isoform b.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK289664.1, DB229053.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000369167.3/
                                             ENSP00000358164.1
            RefSeq Select criteria        :: based on manual assertion,
                                             conservation
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               AC239868.2         96449-96940         c
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..492
                     /gene="H2BC18"
                     /gene_synonym="HIST2H2BF"
                     /note="H2B clustered histone 18"
                     /db_xref="GeneID:440689"
                     /db_xref="HGNC:HGNC:24700"
     exon            1..492
                     /gene="H2BC18"
                     /gene_synonym="HIST2H2BF"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..428
                     /gene="H2BC18"
                     /gene_synonym="HIST2H2BF"
                     /note="isoform a is encoded by transcript variant 1;
                     histone H2B type 2-F; histone cluster 2, H2bf; histone
                     cluster 2 H2B family member f"
                     /codon_start=1
                     /product="histone H2B type 2-F isoform a"
                     /protein_id="NP_001019770.1"
                     /db_xref="CCDS:CCDS30846.1"
                     /db_xref="GeneID:440689"
                     /db_xref="HGNC:HGNC:24700"
                     /translation="MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 agttcggatt acttctttaa gtctcttttc tcttttttcg cgcaaaaatg ccggatccag
       61 cgaaatccgc tcctgctccc aagaagggct ccaaaaaggc tgttacgaaa gtgcagaaga
      121 aggacggcaa gaagcgcaag cgcagccgca aggagagcta ctccgtttac gtgtacaagg
      181 tgctgaagca ggtccacccc gacaccggca tctcgtccaa ggccatgggc atcatgaact
      241 ccttcgtcaa cgacatcttc gagcgcatcg cgggagaggc gtcccgcctg gcgcactaca
      301 acaagcgctc caccatcaca tcccgcgaga tccagacggc cgtgcgcctg ctgctgcccg
      361 gcgagctggc caagcacgcc gtgtccgagg gcaccaaggc ggtcaccaag tacaccagct
      421 cgaagtaaga gtgtgcaagg gacgcaatag atcaaccacc taaccccaaa ggctcttttc
      481 agagccactt ca
//
