LOCUS       NM_003527                467 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 17 (H2BC17), mRNA.
ACCESSION   NM_003527
VERSION     NM_003527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 467)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 467)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (bases 1 to 467)
  AUTHORS   Beck,H.C., Nielsen,E.C., Matthiesen,R., Jensen,L.H., Sehested,M.,
            Finn,P., Grauslund,M., Hansen,A.M. and Jensen,O.N.
  TITLE     Quantitative proteomic analysis of post-translational modifications
            of human histones
  JOURNAL   Mol Cell Proteomics 5 (7), 1314-1325 (2006)
   PUBMED   16627869
REFERENCE   5  (bases 1 to 467)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   6  (bases 1 to 467)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 467)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 467)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 467)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   10 (bases 1 to 467)
  AUTHORS   Dobner,T., Wolf,I., Mai,B. and Lipp,M.
  TITLE     A novel divergently transcribed human histone H2A/H2B gene pair
  JOURNAL   DNA Seq 1 (6), 409-413 (1991)
   PUBMED   1768865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98744.2.
            
            On Oct 22, 2001 this sequence version replaced NM_003527.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BX647290.1, BC106720.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000616182.2/
                                             ENSP00000477527.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               Z98744.2           57166-57632
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..467
                     /gene="H2BC17"
                     /gene_synonym="dJ193B12.2; H2B.2; H2B/n; H2BFN; HIST1H2BO"
                     /note="H2B clustered histone 17"
                     /db_xref="GeneID:8348"
                     /db_xref="HGNC:HGNC:4758"
                     /db_xref="MIM:602808"
     exon            1..467
                     /gene="H2BC17"
                     /gene_synonym="dJ193B12.2; H2B.2; H2B/n; H2BFN; HIST1H2BO"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..419
                     /gene="H2BC17"
                     /gene_synonym="dJ193B12.2; H2B.2; H2B/n; H2BFN; HIST1H2BO"
                     /note="H2B histone family, member N; histone 1, H2bo;
                     histone H2B.2; histone H2B.n; histone cluster 1, H2bo;
                     histone cluster 1 H2B family member o"
                     /codon_start=1
                     /product="histone H2B type 1-O"
                     /protein_id="NP_003518.2"
                     /db_xref="CCDS:CCDS4640.1"
                     /db_xref="GeneID:8348"
                     /db_xref="HGNC:HGNC:4758"
                     /db_xref="MIM:602808"
                     /translation="MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     polyA_site      466
                     /gene="H2BC17"
                     /gene_synonym="dJ193B12.2; H2B.2; H2B/n; H2BFN; HIST1H2BO"
                     /note="major polyA site"
ORIGIN      
        1 attcttgtta tttgagtgct ctttcactct cctccgccat gcccgacccg gctaaatctg
       61 ctcctgcccc caaaaagggc tccaagaaag ccgtaaccaa ggcccagaaa aaggacggca
      121 agaagcgcaa gcgcagccgc aaagagagtt actctatcta cgtgtacaag gtgctgaagc
      181 aagtccaccc cgacaccggc atctcatcga aggccatggg catcatgaac tccttcgtca
      241 atgacatctt tgagcgcatc gctggcgagg cttcccgcct ggcgcattac aacaagcgct
      301 cgaccatcac ctccagggag atccagacgg ccgtgcgcct gctgctgccc ggggagctgg
      361 ccaagcacgc cgtgtccgag ggcacaaagg ccgtcaccaa gtacaccagc tccaagtgag
      421 ctctcgcagc tgccagcaat ccaaaggctc ttttcagagc cactcac
//
