LOCUS       NM_003520                542 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 15 (H2BC15), mRNA.
ACCESSION   NM_003520
VERSION     NM_003520.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 542)
  AUTHORS   Liao,Y.P., Chen,L.Y., Huang,R.L., Su,P.H., Chan,M.W., Chang,C.C.,
            Yu,M.H., Wang,P.H., Yen,M.S., Nephew,K.P. and Lai,H.C.
  TITLE     Hypomethylation signature of tumor-initiating cells predicts poor
            prognosis of ovarian cancer patients
  JOURNAL   Hum Mol Genet 23 (7), 1894-1906 (2014)
   PUBMED   24256813
  REMARK    GeneRIF: Hypomethylation of ATG4A and HIST1H2BN in ovarian
            tumor-initiating cells predicts a poor prognosis for ovarian cancer
            patients.
REFERENCE   2  (bases 1 to 542)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 542)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 542)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   5  (bases 1 to 542)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   6  (bases 1 to 542)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 542)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 542)
  AUTHORS   Albig,W., Trappe,R., Kardalinou,E., Eick,S. and Doenecke,D.
  TITLE     The human H2A and H2B histone gene complement
  JOURNAL   Biol Chem 380 (1), 7-18 (1999)
   PUBMED   10064132
REFERENCE   9  (bases 1 to 542)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   10 (bases 1 to 542)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98744.2.
            
            On Dec 3, 2019 this sequence version replaced NM_003520.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK130106.1, DB205835.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000612898.2/
                                             ENSP00000483903.1
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               Z98744.2           2310-2851
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..542
                     /gene="H2BC15"
                     /gene_synonym="H2B/d; H2BFD; HIST1H2BN"
                     /note="H2B clustered histone 15"
                     /db_xref="GeneID:8341"
                     /db_xref="HGNC:HGNC:4749"
                     /db_xref="MIM:602801"
     exon            1..542
                     /gene="H2BC15"
                     /gene_synonym="H2B/d; H2BFD; HIST1H2BN"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..474
                     /gene="H2BC15"
                     /gene_synonym="H2B/d; H2BFD; HIST1H2BN"
                     /note="H2B histone family, member D; histone 1, H2bn;
                     histone H2B.d; histone cluster 1, H2bn; histone cluster 1
                     H2B family member n"
                     /codon_start=1
                     /product="histone H2B type 1-N"
                     /protein_id="NP_003511.1"
                     /db_xref="CCDS:CCDS4633.1"
                     /db_xref="GeneID:8341"
                     /db_xref="HGNC:HGNC:4749"
                     /db_xref="MIM:602801"
                     /translation="MPEPSKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 acttgcgtta agaagcagtg aataagcggt aggttgacag agctaccgtc ttcctgtttt
       61 tttcctccaa ttttccggca gttactccca gtcatgcccg agccctcaaa gtccgctcct
      121 gccccgaaga aaggctccaa gaaggcagtg acaaaggccc agaagaagga cggcaagaag
      181 cgcaagcgca gccgcaagga gagctactcc gtgtacgtgt acaaggtgct gaagcaggtc
      241 caccccgaca ccggtatctc gtccaaggcc atgggcatca tgaactcctt cgtcaatgac
      301 atcttcgagc gcatcgccgg cgaggcttcc cgcctggcgc attacaacaa gcgctcgacc
      361 atcacctcca gggagatcca gacggccgtg cgcctgctgc tgccagggga gctggccaag
      421 cacgcggtgt cggagggcac caaggccgtc accaagtaca ccagttccaa gtgagcccgc
      481 ccaccgcgga acgttcggtc agtctcggcc cacaccccaa aggctctttt cagagccact
      541 ca
//
