LOCUS       NM_003519                451 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 13 (H2BC13), mRNA.
ACCESSION   NM_003519
VERSION     NM_003519.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
            Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
  TITLE     Proteomic analysis identifies dysfunction in cellular transport,
            energy, and protein metabolism in different brain regions of
            atypical frontotemporal lobar degeneration
  JOURNAL   J Proteome Res 11 (4), 2533-2543 (2012)
   PUBMED   22360420
  REMARK    GeneRIF: A protein encoded by this locus was found to be
            differentially expressed in postmortem brains from patients with
            atypical frontotemporal lobar degeneration.
REFERENCE   3  (bases 1 to 451)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 451)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 451)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 451)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 451)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   8  (bases 1 to 451)
  AUTHORS   Albig,W., Trappe,R., Kardalinou,E., Eick,S. and Doenecke,D.
  TITLE     The human H2A and H2B histone gene complement
  JOURNAL   Biol Chem 380 (1), 7-18 (1999)
   PUBMED   10064132
REFERENCE   9  (bases 1 to 451)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   10 (bases 1 to 451)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL009179.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003519.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the small histone gene cluster on chromosome 6p22-p21.3. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB258565.1, AK312114.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000377401.4/
                                             ENSP00000366618.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AL009179.1         135630-136080       c
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..451
                     /gene="H2BC13"
                     /gene_synonym="dJ97D16.4; H2B/c; H2BFC; HIST1H2BL"
                     /note="H2B clustered histone 13"
                     /db_xref="GeneID:8340"
                     /db_xref="HGNC:HGNC:4748"
                     /db_xref="MIM:602800"
     exon            1..451
                     /gene="H2BC13"
                     /gene_synonym="dJ97D16.4; H2B/c; H2BFC; HIST1H2BL"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..404
                     /gene="H2BC13"
                     /gene_synonym="dJ97D16.4; H2B/c; H2BFC; HIST1H2BL"
                     /note="H2B histone family, member C; histone 1, H2bl;
                     histone H2B.c; histone cluster 1, H2bl; histone cluster 1
                     H2B family member l"
                     /codon_start=1
                     /product="histone H2B type 1-L"
                     /protein_id="NP_003510.1"
                     /db_xref="CCDS:CCDS4625.1"
                     /db_xref="GeneID:8340"
                     /db_xref="HGNC:HGNC:4748"
                     /db_xref="MIM:602800"
                     /translation="MPELAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     polyA_site      451
                     /gene="H2BC13"
                     /gene_synonym="dJ97D16.4; H2B/c; H2BFC; HIST1H2BL"
                     /note="major polyA site"
ORIGIN      
        1 ggttttgcca ctattgtttc attatgcccg agctggccaa gtctgctccc gccccgaaga
       61 agggctccaa gaaggcggtg accaaggccc agaagaagga tggcaagaag cgcaagcgca
      121 gccgcaagga gagctactcc gtgtacgtgt acaaggtgct gaagcaggtc caccccgaca
      181 ccggcatctc ttctaaggcc atgggaatca tgaactcctt cgtcaacgac atcttcgagc
      241 gcatcgcaag cgaggcttcc cgcctggcgc actacaacaa gcgctcgacc atcacctcca
      301 gggagatcca gaccgccgtg cgcctgctgc ttccggggga gctggccaag cacgcggtgt
      361 cggagggcac caaggccgtc accaagtaca ccagctccaa gtaaattctc aagctcttgt
      421 ccaacccaaa ggctcttttc agagccactc a
//
