LOCUS       NM_017445                467 bp    mRNA    linear   PRI 25-OCT-2021
DEFINITION  Homo sapiens H2B clustered histone 12 like (H2BC12L), mRNA.
ACCESSION   NM_017445
VERSION     NM_017445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A and
            Reinberg D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Bonenfant D, Coulot M, Towbin H, Schindler P and van Oostrum J.
  TITLE     Characterization of histone H2A and H2B variants and their
            post-translational modifications by mass spectrometry
  JOURNAL   Mol Cell Proteomics 5 (3), 541-552 (2006)
   PUBMED   16319397
REFERENCE   3  (bases 1 to 467)
  AUTHORS   Zhu B, Zheng Y, Pham AD, Mandal SS, Erdjument-Bromage H, Tempst P
            and Reinberg D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   4  (bases 1 to 467)
  AUTHORS   Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser
            A, Etkin LD, Chernoff J, Earnshaw WC and Allis CD.
  TITLE     Apoptotic phosphorylation of histone H2B is mediated by mammalian
            sterile twenty kinase
  JOURNAL   Cell 113 (4), 507-517 (2003)
   PUBMED   12757711
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001051.1.
            
            On May 17, 2019 this sequence version replaced NM_017445.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AA385278.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599962.2/ ENSP00000481622.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AP001051.1         4075-4541
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..467
                     /gene="H2BC12L"
                     /gene_synonym="H2B/s; H2BFS; H2BS1"
                     /note="H2B clustered histone 12 like"
                     /db_xref="GeneID:54145"
                     /db_xref="HGNC:HGNC:4762"
     exon            1..467
                     /gene="H2BC12L"
                     /gene_synonym="H2B/s; H2BFS; H2BS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..438
                     /gene="H2BC12L"
                     /gene_synonym="H2B/s; H2BFS; H2BS1"
                     /note="histone protein; histone H2B.s; H2B histone family
                     member S; H2B.S histone 1"
                     /codon_start=1
                     /product="histone H2B type F-S"
                     /protein_id="NP_059141.1"
                     /db_xref="GeneID:54145"
                     /db_xref="HGNC:HGNC:4762"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGRKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLPHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSAK"
ORIGIN      
        1 attacttccc gttttcacga tctgctgctc gtctcaggct cgtagttcgc cttcaacatg
       61 ccggagccag cgaagtccgc tcccgcgccc aagaagggct cgaagaaagc cgtgactaag
      121 gcgcagaaga aggacggcag gaagcgcaag cgcagccgca aggagagcta ctccgtatac
      181 gtgtacaagg tgctgaagca ggtccacccc gacaccggca tctcctctaa ggccatggga
      241 atcatgaact ccttcgtcaa cgacatcttc gaacgcatcg caggtgaggc ttcccgcctg
      301 ccgcattaca acaagcgctc gaccatcacc tccagggaga tccagacggc cgtgcgcctg
      361 ctgctgcccg gggagttggc caagcacgcc gtgtccgagg gcaccaaggc cgtcaccaag
      421 tacaccagcg ctaagtaaac ttgccaaatt gatgcctgca gctcctg
//
