LOCUS       NM_001312653             495 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 12 (H2BC12), transcript variant
            1, mRNA.
ACCESSION   NM_001312653
VERSION     NM_001312653.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Valencia,A.M., Collings,C.K., Dao,H.T., St Pierre,R., Cheng,Y.C.,
            Huang,J., Sun,Z.Y., Seo,H.S., Mashtalir,N., Comstock,D.E.,
            Bolonduro,O., Vangos,N.E., Yeoh,Z.C., Dornon,M.K., Hermawan,C.,
            Barrett,L., Dhe-Paganon,S., Woolf,C.J., Muir,T.W. and Kadoch,C.
  TITLE     Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch
            Interaction Site That Potentiates mSWI/SNF Complex Chromatin
            Remodeling
  JOURNAL   Cell 179 (6), 1342-1356 (2019)
   PUBMED   31759698
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Wang,J., Wang,S., Yan,C., Deng,Y., Huang,Z. and Shi,P.
  TITLE     Mass spectrometry-based proteomic analysis reveals the interacting
            partners of lipin1
  JOURNAL   IUBMB Life 70 (8), 753-762 (2018)
   PUBMED   30092116
  REMARK    GeneRIF: The physical interaction between lipin1 and eEF1A1 was
            further affirmed in 293T cells transfected with 6-His tagged lipin1
            and hepatocyte SMMC7721 cells by protein immunoprecipitation and
            immunofluorescence microscopy. Lipin1 also interacted with
            HIST1H2BK, which was confirmed in SMMC7721 cells by protein
            immunoprecipitation.
REFERENCE   3  (bases 1 to 495)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 495)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   5  (bases 1 to 495)
  AUTHORS   Howell,S.J., Wilk,D., Yadav,S.P. and Bevins,C.L.
  TITLE     Antimicrobial polypeptides of the human colonic epithelium
  JOURNAL   Peptides 24 (11), 1763-1770 (2003)
   PUBMED   15019208
  REMARK    GeneRIF: Histone H2B antimicrobial peptides exhibit antibacterial
            activity and contribute to the formation of the antimicrobial
            barrier of the colonic epithelium
REFERENCE   6  (bases 1 to 495)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 495)
  AUTHORS   Lorain,S., Quivy,J.P., Monier-Gavelle,F., Scamps,C., Lecluse,Y.,
            Almouzni,G. and Lipinski,M.
  TITLE     Core histones and HIRIP3, a novel histone-binding protein, directly
            interact with WD repeat protein HIRA
  JOURNAL   Mol Cell Biol 18 (9), 5546-5556 (1998)
   PUBMED   9710638
REFERENCE   8  (bases 1 to 495)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   9  (bases 1 to 495)
  AUTHORS   Frohm,M., Gunne,H., Bergman,A.C., Agerberth,B., Bergman,T.,
            Boman,A., Liden,S., Jornvall,H. and Boman,H.G.
  TITLE     Biochemical and antibacterial analysis of human wound and blister
            fluid
  JOURNAL   Eur J Biochem 237 (1), 86-92 (1996)
   PUBMED   8620898
REFERENCE   10 (bases 1 to 495)
  AUTHORS   Dobner,T., Wolf,I., Mai,B. and Lipp,M.
  TITLE     A novel divergently transcribed human histone H2A/H2B gene pair
  JOURNAL   DNA Seq 1 (6), 409-413 (1991)
   PUBMED   1768865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021807.2.
            
            On Dec 3, 2019 this sequence version replaced NM_001312653.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family. The protein encoded is an
            antimicrobial protein with antibacterial and antifungal activity.
            Two transcripts that encode the same protein have been identified
            for this gene, which is found in the histone microcluster on
            chromosome 6p21.33. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) contains a palindromic
            termination sequence instead of a polyA signal and tail. Variants 1
            and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK292062.1, DA964711.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000356950.2/
                                             ENSP00000349430.2
            RefSeq Select criteria        :: based on manual assertion,
                                             conservation, longest protein
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AL021807.2         69666-70160         c
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..495
                     /gene="H2BC12"
                     /gene_synonym="H2B/S; H2BFAiii; H2BFT; H2BK; HIST1H2BK"
                     /note="H2B clustered histone 12"
                     /db_xref="GeneID:85236"
                     /db_xref="HGNC:HGNC:13954"
                     /db_xref="MIM:615045"
     exon            1..495
                     /gene="H2BC12"
                     /gene_synonym="H2B/S; H2BFAiii; H2BFT; H2BK; HIST1H2BK"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..438
                     /gene="H2BC12"
                     /gene_synonym="H2B/S; H2BFAiii; H2BFT; H2BK; HIST1H2BK"
                     /note="H2B histone family, member T; histone family
                     member; histone 1, H2bk; H2B K; HIRA-interacting protein
                     1; histone cluster 1, H2bk; histone cluster 1 H2B family
                     member k"
                     /codon_start=1
                     /product="histone H2B type 1-K"
                     /protein_id="NP_001299582.1"
                     /db_xref="CCDS:CCDS4621.1"
                     /db_xref="GeneID:85236"
                     /db_xref="HGNC:HGNC:13954"
                     /db_xref="MIM:615045"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSAK"
ORIGIN      
        1 attacttccc gttttctcga tctgctgctc gtctcaggct cgtagttcgc cttcaacatg
       61 ccggaaccag cgaagtccgc tcccgcgccc aagaagggct cgaagaaagc cgtgactaag
      121 gcgcagaaga aggacggcaa gaagcgcaag cgcagccgca aggagagcta ctccgtatac
      181 gtgtacaagg tgctgaagca ggtccacccc gacaccggca tctcctctaa ggccatggga
      241 atcatgaact ccttcgtcaa cgacatcttc gaacgcatcg cgggtgaggc ttcccgcctg
      301 gcgcattaca acaagcgctc gaccatcacc tccagggaga tccagacggc cgtgcgcctg
      361 ctgctgcccg gggagttggc caagcacgcc gtgtccgagg gcaccaaggc cgtcaccaag
      421 tacaccagcg ctaagtaaac ttgccaagta agcgtcttaa agcccaaccc caaaggctct
      481 tttaagagcc actta
//
