LOCUS       NM_003525                482 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens H2B clustered histone 10 (H2BC10), mRNA.
ACCESSION   NM_003525
VERSION     NM_003525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Budziszewski,G.R., Zhao,Y., Spangler,C.J., Kedziora,K.M.,
            Williams,M.R., Azzam,D.N., Skrajna,A., Koyama,Y., Cesmat,A.P.,
            Simmons,H.C., Arteaga,E.C., Strauss,J.D., Kireev,D. and
            McGinty,R.K.
  TITLE     Multivalent DNA and nucleosome acidic patch interactions specify
            VRK1 mitotic localization and activity
  JOURNAL   Nucleic Acids Res 50 (8), 4355-4371 (2022)
   PUBMED   35390161
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 482)
  AUTHORS   Wilson,M.D., Benlekbir,S., Fradet-Turcotte,A., Sherker,A.,
            Julien,J.P., McEwan,A., Noordermeer,S.M., Sicheri,F.,
            Rubinstein,J.L. and Durocher,D.
  TITLE     The structural basis of modified nucleosome recognition by 53BP1
  JOURNAL   Nature 536 (7614), 100-103 (2016)
   PUBMED   27462807
REFERENCE   4  (bases 1 to 482)
  AUTHORS   Falk,S.J., Guo,L.Y., Sekulic,N., Smoak,E.M., Mani,T., Logsdon,G.A.,
            Gupta,K., Jansen,L.E., Van Duyne,G.D., Vinogradov,S.A.,
            Lampson,M.A. and Black,B.E.
  TITLE     Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at
            the centromere
  JOURNAL   Science 348 (6235), 699-703 (2015)
   PUBMED   25954010
REFERENCE   5  (bases 1 to 482)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 482)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 482)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   8  (bases 1 to 482)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 482)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
REFERENCE   10 (bases 1 to 482)
  AUTHORS   Ohe,Y., Hayashi,H. and Iwai,K.
  TITLE     Human spleen histone H2B. Isolation and amino acid sequence
  JOURNAL   J Biochem 85 (2), 615-624 (1979)
   PUBMED   422550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031777.5.
            
            On Dec 3, 2019 this sequence version replaced NM_003525.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. The protein has antibacterial and antifungal antimicrobial
            activity. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC101655.1, DA509995.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000377733.4/
                                                  ENSP00000366962.3
            Protein has antimicrobial activity :: PMID: 12860195
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            replication-dependent histone      :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AL031777.5         78313-78794
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..482
                     /gene="H2BC10"
                     /gene_synonym="H2B/k; H2BC4; H2BC6; H2BC7; H2BC8; H2BFK;
                     HIST1H2BI"
                     /note="H2B clustered histone 10"
                     /db_xref="GeneID:8346"
                     /db_xref="HGNC:HGNC:4756"
                     /db_xref="MIM:602807"
     exon            1..482
                     /gene="H2BC10"
                     /gene_synonym="H2B/k; H2BC4; H2BC6; H2BC7; H2BC8; H2BFK;
                     HIST1H2BI"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..426
                     /gene="H2BC10"
                     /gene_synonym="H2B/k; H2BC4; H2BC6; H2BC7; H2BC8; H2BFK;
                     HIST1H2BI"
                     /note="H2B histone family, member K; histone 1, H2bi;
                     histone H2B.k; histone H2B.1 A; histone cluster 1, H2bi;
                     histone cluster 1 H2B family member i"
                     /codon_start=1
                     /product="histone H2B type 1-C/E/F/G/I"
                     /protein_id="NP_003516.1"
                     /db_xref="CCDS:CCDS4603.1"
                     /db_xref="GeneID:8346"
                     /db_xref="HGNC:HGNC:4756"
                     /db_xref="MIM:602807"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 agcattttcc tgtggtcatt tgacggtatc acttcggctg cgaacatgcc tgaaccagct
       61 aagtcagctc ccgccccgaa gaagggctcc aagaaggcgg tgaccaaggc acagaagaag
      121 gatggcaaga agcgcaagcg cagccgcaag gagagctatt ccgtgtacgt gtacaaggtg
      181 ctgaagcagg tccaccccga caccggcatc tcgtccaagg ctatggggat tatgaactcc
      241 ttcgtcaacg acattttcga gcgcattgca ggcgaggctt cccgcctggc gcattataac
      301 aagcgctcga ccatcacttc cagggagatc caaacggctg tgcgcctgct gctacccggg
      361 gagctggcca aacacgcggt gtcggagggc accaaggcgg tcaccaagta caccagctcc
      421 aagtaaacta gttacctggg taaaagcgct aacgacccaa aggctcttct aagagccacc
      481 ca
//
