LOCUS       NM_170610                569 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2B clustered histone 1 (H2BC1), mRNA.
ACCESSION   NM_170610
VERSION     NM_170610.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 569)
  AUTHORS   Brighenti,E., Carnicelli,D., Brigotti,M. and Fiume,L.
  TITLE     The inhibition of lactate dehydrogenase A hinders the transcription
            of histone 2B gene independently from the block of aerobic
            glycolysis
  JOURNAL   Biochem Biophys Res Commun 485 (4), 742-745 (2017)
   PUBMED   28257841
  REMARK    GeneRIF: Data indicate that lactate dehydrogenase A (LDHA) is
            involved in the transcription of histone 2B gene.
REFERENCE   2  (bases 1 to 569)
  AUTHORS   Padavattan,S., Thiruselvam,V., Shinagawa,T., Hasegawa,K.,
            Kumasaka,T., Ishii,S. and Kumarevel,T.
  TITLE     Structural analyses of the nucleosome complexes with human
            testis-specific histone variants, hTh2a and hTh2b
  JOURNAL   Biophys Chem 221, 41-48 (2017)
   PUBMED   27992841
REFERENCE   3  (bases 1 to 569)
  AUTHORS   Nardozza,A.P. and Ladurner,A.G.
  TITLE     Nick Your DNA, Mark Your Chromatin
  JOURNAL   Mol Cell 64 (1), 7-9 (2016)
   PUBMED   27716488
  REMARK    GeneRIF: In a process of single-strand DNA repair, PARP3
            mono-ADP-ribosylates nucleosomal histone H2B.
REFERENCE   4  (bases 1 to 569)
  AUTHORS   Huynh,L.M., Shinagawa,T. and Ishii,S.
  TITLE     Two Histone Variants TH2A and TH2B Enhance Human Induced
            Pluripotent Stem Cell Generation
  JOURNAL   Stem Cells Dev 25 (3), 251-258 (2016)
   PUBMED   26649967
REFERENCE   5  (bases 1 to 569)
  AUTHORS   Cang,S., Xu,X., Ma,Y., Liu,D. and Chiao,J.W.
  TITLE     Hypoacetylation, hypomethylation, and dephosphorylation of H2B
            histones and excessive histone deacetylase activity in DU-145
            prostate cancer cells
  JOURNAL   J Hematol Oncol 9, 3 (2016)
   PUBMED   26759222
  REMARK    GeneRIF: Data show that histone H2B of prostate cancer cell line
            DU-145 have hypoacetylation, hypomethylation, and
            dephosphorylation, suggesting there was an excessive histone
            deacetylase activity in the cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 569)
  AUTHORS   Zalensky,A.O., Siino,J.S., Gineitis,A.A., Zalenskaya,I.A.,
            Tomilin,N.V., Yau,P. and Bradbury,E.M.
  TITLE     Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning
            and characterization
  JOURNAL   J Biol Chem 277 (45), 43474-43480 (2002)
   PUBMED   12213818
REFERENCE   7  (bases 1 to 569)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   8  (bases 1 to 569)
  AUTHORS   Deng,L., Wang,D., de la Fuente,C., Wang,L., Li,H., Lee,C.G.,
            Donnelly,R., Wade,J.D., Lambert,P. and Kashanchi,F.
  TITLE     Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
  JOURNAL   Virology 289 (2), 312-326 (2001)
   PUBMED   11689053
REFERENCE   9  (bases 1 to 569)
  AUTHORS   Deng,L., de la Fuente,C., Fu,P., Wang,L., Donnelly,R., Wade,J.D.,
            Lambert,P., Li,H., Lee,C.G. and Kashanchi,F.
  TITLE     Acetylation of HIV-1 Tat by CBP/P300 increases transcription of
            integrated HIV-1 genome and enhances binding to core histones
  JOURNAL   Virology 277 (2), 278-295 (2000)
   PUBMED   11080476
REFERENCE   10 (bases 1 to 569)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512384.9.
            
            On Dec 3, 2019 this sequence version replaced NM_170610.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a testis/sperm-specific
            member of the histone H2B family. Transcripts from this gene
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DB084768.1, AK312055.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000274764.5/
                                             ENSP00000274764.3
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               AL512384.9         33927-34495
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..569
                     /gene="H2BC1"
                     /gene_synonym="bA317E16.3; H2BFU; HIST1H2BA; hTSH2B; STBP;
                     TH2B; TSH2B; TSH2B.1"
                     /note="H2B clustered histone 1"
                     /db_xref="GeneID:255626"
                     /db_xref="HGNC:HGNC:18730"
                     /db_xref="MIM:609904"
     exon            1..569
                     /gene="H2BC1"
                     /gene_synonym="bA317E16.3; H2BFU; HIST1H2BA; hTSH2B; STBP;
                     TH2B; TSH2B; TSH2B.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..516
                     /gene="H2BC1"
                     /gene_synonym="bA317E16.3; H2BFU; HIST1H2BA; hTSH2B; STBP;
                     TH2B; TSH2B; TSH2B.1"
                     /note="H2B histone family, member U, (testis-specific);
                     histone cluster 1 H2B family member a; histone 1, H2ba;
                     histone cluster 1, H2ba; testis-specific histone H2B;
                     histone H2B, testis"
                     /codon_start=1
                     /product="histone H2B type 1-A"
                     /protein_id="NP_733759.1"
                     /db_xref="CCDS:CCDS4563.1"
                     /db_xref="GeneID:255626"
                     /db_xref="HGNC:HGNC:18730"
                     /db_xref="MIM:609904"
                     /translation="MPEVSSKGATISKKGFKKAVVKTQKKEGKKRKRTRKESYSIYIY
                     KVLKQVHPDTGISSKAMSIMNSFVTDIFERIASEASRLAHYSKRSTISSREIQTAVRL
                     LLPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 gtttgtttac ttggcgagac ttggagctga ggtcatttgg agctgtttaa tactgaagag
       61 ctgttgagca ctggaaagtg ctgtgtaacc ctggaaaaga accgtgtaac gctgcagaag
      121 tgtgtggtag ctatgccgga ggtgtcatct aaaggtgcta ccatttccaa gaagggcttt
      181 aagaaagctg tcgttaagac ccagaaaaag gaaggcaaaa agcgcaagag gacccgtaag
      241 gagagttatt ctatttacat ctacaaagtg ctaaagcagg tccatccgga cactggcatc
      301 tcttcgaaag ctatgagcat tatgaattcc ttcgtcactg atatctttga gcgtatagcg
      361 agcgaggcat cacgtttggc tcactacagc aagcgctcca ccatttcttc cagagagatt
      421 cagacagcag tgcgcttgct actgccggga gagctggcta aacatgctgt gtctgagggc
      481 accaaggctg tcactaagta caccagctcc aagtaagcct gctaagtaaa cgtcatttct
      541 aacccaaagg ctcttttcag agccactta
//
