LOCUS       NM_002106                866 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens H2A.Z variant histone 1 (H2AZ1), mRNA.
ACCESSION   NM_002106
VERSION     NM_002106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 866)
  AUTHORS   Gao,J., Lu,Q., Zhong,J., Li,Z., Pan,L., Feng,C., Tang,S., Wang,X.,
            Tao,Y., Zhou,X. and Wang,Q.
  TITLE     Identification and validation of an H2AZ1-based index model: a
            novel prognostic tool for hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 16 (3), 2542-2562 (2024)
   PUBMED   38305811
  REMARK    GeneRIF: Identification and validation of an H2AZ1-based index
            model: a novel prognostic tool for hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 866)
  AUTHORS   Liu,T., Wang,H., Chen,Y., Wan,Z., Du,Z., Shen,H., Yu,Y., Ma,S.,
            Xu,Y., Li,Z., Yu,N., Zhang,F., Cao,K., Cai,J., Zhang,W., Gao,F. and
            Yang,Y.
  TITLE     SENP5 promotes homologous recombination-mediated DNA damage repair
            in colorectal cancer cells through H2AZ deSUMOylation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 234 (2023)
   PUBMED   37684630
  REMARK    GeneRIF: SENP5 promotes homologous recombination-mediated DNA
            damage repair in colorectal cancer cells through H2AZ
            deSUMOylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 866)
  AUTHORS   Ye,L., Fan,T., Qin,Y., Qiu,C., Li,L., Dai,M., Zhou,Y., Chen,Y. and
            Jiang,Y.
  TITLE     MicroRNA-455-3p accelerate malignant progression of tumor by
            targeting H2AFZ in colorectal cancer
  JOURNAL   Cell Cycle 22 (7), 777-795 (2023)
   PUBMED   36482739
  REMARK    GeneRIF: MicroRNA-455-3p accelerate malignant progression of tumor
            by targeting H2AFZ in colorectal cancer.
REFERENCE   4  (bases 1 to 866)
  AUTHORS   Avila-Lopez,P.A., Nunez-Martinez,H.N., Peralta-Alvarez,C.A.,
            Martinez-Calvillo,S., Recillas-Targa,F. and Hernandez-Rivas,R.
  TITLE     Interplay Between the Histone Variant H2A.Z and the Epigenome in
            Pancreatic Cancer
  JOURNAL   Arch Med Res 53 (8), 840-858 (2022)
   PUBMED   36470770
  REMARK    GeneRIF: Interplay Between the Histone Variant H2A.Z and the
            Epigenome in Pancreatic Cancer.
REFERENCE   5  (bases 1 to 866)
  AUTHORS   Wang,Q., Qi,Y., Xiong,F., Wang,D., Wang,B. and Chen,Y.
  TITLE     The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the
            nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma
            cells
  JOURNAL   BMC Cancer 22 (1), 1166 (2022)
   PUBMED   36368958
  REMARK    GeneRIF: The H2A.Z-KDM1A complex promotes tumorigenesis by
            localizing in the nucleus to promote SFRP1 promoter methylation in
            cholangiocarcinoma cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 866)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   7  (bases 1 to 866)
  AUTHORS   Hatch,C.L. and Bonner,W.M.
  TITLE     Characterization of the proximal promoter of the human histone
            H2A.Z gene
  JOURNAL   DNA Cell Biol 14 (3), 257-266 (1995)
   PUBMED   7880446
REFERENCE   8  (bases 1 to 866)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 866)
  AUTHORS   Hatch,C.L. and Bonner,W.M.
  TITLE     The human histone H2A.Z gene. Sequence and regulation
  JOURNAL   J Biol Chem 265 (25), 15211-15218 (1990)
   PUBMED   1697587
REFERENCE   10 (bases 1 to 866)
  AUTHORS   Hatch,C.L. and Bonner,W.M.
  TITLE     Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged
            but highly conserved basal histone H2A isoprotein species
  JOURNAL   Nucleic Acids Res 16 (3), 1113-1124 (1988)
   PUBMED   3344202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097460.3.
            
            On Nov 23, 2018 this sequence version replaced NM_002106.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent member of
            the histone H2A family that is distinct from other members of the
            family. Studies in mice have shown that this particular histone is
            required for embryonic development and indicate that lack of
            functional histone H2A leads to embryonic lethality. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018002.1, BG616099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000296417.6/
                                               ENSP00000296417.5
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC097460.3         59825-59932         c
            109-186             AC097460.3         59320-59397         c
            187-300             AC097460.3         58930-59043         c
            301-430             AC097460.3         58468-58597         c
            431-866             AC097460.3         57745-58180         c
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..866
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /note="H2A.Z variant histone 1"
                     /db_xref="GeneID:3015"
                     /db_xref="HGNC:HGNC:4741"
                     /db_xref="MIM:142763"
     exon            1..108
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..492
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /note="H2AZ histone; H2A histone family member Z"
                     /codon_start=1
                     /product="histone H2A.Z"
                     /protein_id="NP_002097.1"
                     /db_xref="CCDS:CCDS3654.1"
                     /db_xref="GeneID:3015"
                     /db_xref="HGNC:HGNC:4741"
                     /db_xref="MIM:142763"
                     /translation="MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSH
                     GRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIK
                     ATIAGGGVIPHIHKSLIGKKGQQKTV"
     exon            109..186
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /inference="alignment:Splign:2.1.0"
     exon            187..300
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /inference="alignment:Splign:2.1.0"
     exon            301..430
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /inference="alignment:Splign:2.1.0"
     exon            431..866
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="H2AZ1"
                     /gene_synonym="H2A.z; H2A.Z-1; H2A/z; H2AFZ; H2AZ"
                     /note="major polyA site"
ORIGIN      
        1 gcagtttgaa tcgcggtgcg acgaaggagt aggtggtggg atctcaccgt gggtccgatt
       61 agccttttct ctgccttgct tgcttgagct tcagcggaat tcgaaatggc tggcggtaag
      121 gctggaaagg actccggaaa ggccaagaca aaggcggttt cccgctcgca gagagccggc
      181 ttgcagttcc cagtgggccg tattcatcga cacctaaaat ctaggacgac cagtcatgga
      241 cgtgtgggcg cgactgccgc tgtgtacagc gcagccatcc tggagtacct caccgcagag
      301 gtacttgaac tggcaggaaa tgcatcaaaa gacttaaagg taaagcgtat tacccctcgt
      361 cacttgcaac ttgctattcg tggagatgaa gaattggatt ctctcatcaa ggctacaatt
      421 gctggtggtg gtgtcattcc acacatccac aaatctctga ttgggaagaa aggacaacag
      481 aagactgtct aaaggatgcc tggattcctt gttatctcag gactctaaat actctaacag
      541 ctgtccagtg ttggtgattc cagtggactg tatctctgtg aaaaacacaa ttttgccttt
      601 ttgtaattct atttgagcaa gttggaagtt taattagctt tccaaccaac caaatttctg
      661 cattcgagtc ttaaccatat ttaagtgtta ctgtggcttc aaagaagcta ttgattctga
      721 agtagtgggt tttgattgag ttgactgttt ttaaaaaact gtttggattt taattgtgat
      781 gcagaagtta tagtaacaaa catttggttt tgtacagaca ttatttccac tctggtggat
      841 aagttcaata aaggtcatat cccaaa
//
