LOCUS       NM_012274                536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens H2A.P histone (H2AP), mRNA.
ACCESSION   NM_012274 XM_048235 XM_936364
VERSION     NM_012274.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 536)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 536)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 536)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 536)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 536)
  AUTHORS   Molaro,A., Young,J.M. and Malik,H.S.
  TITLE     Evolutionary origins and diversification of testis-specific short
            histone H2A variants in mammals
  JOURNAL   Genome Res 28 (4), 460-473 (2018)
   PUBMED   29549088
REFERENCE   6  (bases 1 to 536)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   7  (bases 1 to 536)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121578.1, AF049615.1 and AW291697.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_012274.1.
            
            Summary: This gene encodes a protein shown to interact with
            huntingtin, which contains an expanded polyglutamine tract in
            individuals with Huntington's disease (PMID: 9700202). [provided by
            RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF049615.1, BC104429.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341016.5/ ENSP00000339511.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL121578.1         157099-157136
            39-464              AF049615.1         1-426
            465-536             AW291697.1         20-91               c
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..536
                     /gene="H2AP"
                     /gene_synonym="CXorf27; HIP17; HYPM"
                     /note="H2A.P histone"
                     /db_xref="GeneID:25763"
                     /db_xref="HGNC:HGNC:18417"
     exon            1..536
                     /gene="H2AP"
                     /gene_synonym="CXorf27; HIP17; HYPM"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..415
                     /gene="H2AP"
                     /gene_synonym="CXorf27; HIP17; HYPM"
                     /note="huntingtin yeast partner M; huntingtin interacting
                     protein M; histone H2A.P"
                     /codon_start=1
                     /product="huntingtin-interacting protein M"
                     /protein_id="NP_036406.1"
                     /db_xref="CCDS:CCDS43929.1"
                     /db_xref="GeneID:25763"
                     /db_xref="HGNC:HGNC:18417"
                     /translation="MSEKKNCKNSSTNNNQTQDPSRNELQVPRSFVDRVVQDERDVQS
                     QSSSTINTLLTLLDCLADYIMERVGLEASNNGSMRNTSQDREREVDNNREPHSAESDV
                     TRFLFDEMPKSRKND"
     regulatory      515..520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AP"
                     /gene_synonym="CXorf27; HIP17; HYPM"
                     /note="hexamer: ATTAAA"
     polyA_site      536
                     /gene="H2AP"
                     /gene_synonym="CXorf27; HIP17; HYPM"
                     /note="major polyA site"
ORIGIN      
        1 agagacctac ttgagctaga gaatcaagca gagctgatga gagccaaacc cagcaaacat
       61 catgtcagag aaaaagaact gtaagaactc gtctacaaat aacaaccaga ctcaagaccc
      121 ttctagaaat gagctacagg tccctaggag cttcgtggac cgcgttgtgc aagatgaacg
      181 agacgtccaa agccagagtt cctccacaat aaataccctc cttaccttgc tcgattgcct
      241 tgctgactac atcatggagc gggtaggctt ggaggccagc aacaatggca gtatgcgcaa
      301 cacttcacaa gatagggaga gagaagtgga caacaaccgt gagccccaca gcgctgagag
      361 tgatgtgact cgctttttgt ttgatgagat gcccaaatcc aggaagaatg actgaagact
      421 gggtcccaga gccttgaagg gaacctcaca ggcttagcca gggcaaaaat gtgtcacagc
      481 tgaggaatat ctgctgttgt catcaacaag tgctattaaa ggatgtaaat ccatga
//
