LOCUS       NM_177925                620 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens H2A.J histone (H2AJ), transcript variant 1, mRNA.
ACCESSION   NM_177925
VERSION     NM_177925.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Freyter,B.M., Abd Al-Razaq,M.A., Hecht,M., Rube,C. and Rube,C.E.
  TITLE     Studies on Human Cultured Fibroblasts and Cutaneous Squamous Cell
            Carcinomas Suggest That Overexpression of Histone Variant H2A.J
            Promotes Radioresistance and Oncogenic Transformation
  JOURNAL   Genes (Basel) 15 (7), 851 (2024)
   PUBMED   39062630
  REMARK    GeneRIF: Studies on Human Cultured Fibroblasts and Cutaneous
            Squamous Cell Carcinomas Suggest That Overexpression of Histone
            Variant H2A.J Promotes Radioresistance and Oncogenic
            Transformation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Redon,C.E., Schmal,Z., Tewary,G., Mangelinck,A., Courbeyrette,R.,
            Thuret,J.Y., Aladjem,M.I., Bonner,W.M., Rube,C.E. and Mann,C.
  TITLE     Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
  JOURNAL   Genes (Basel) 12 (11), 1665 (2021)
   PUBMED   34828271
  REMARK    GeneRIF: Histone Variant H2A.J Is Enriched in Luminal Epithelial
            Gland Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Isermann,A., Mann,C. and Rube,C.E.
  TITLE     Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the
            Secretory Phenotype in Radiation-Induced Senescence
  JOURNAL   Int J Mol Sci 21 (23), 9130 (2020)
   PUBMED   33266246
  REMARK    GeneRIF: Histone Variant H2A.J Marks Persistent DNA Damage and
            Triggers the Secretory Phenotype in Radiation-Induced Senescence.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Wiesner,J. and Vilcinskas,A.
  TITLE     Antimicrobial peptides: the ancient arm of the human immune system
  JOURNAL   Virulence 1 (5), 440-464 (2010)
   PUBMED   21178486
  REMARK    GeneRIF: The antimicrobial protein buforin I results from
            proteolytic cleavage of the histone protein H2A in the stomach.
            Review article
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Yao,J., Weremowicz,S., Feng,B., Gentleman,R.C., Marks,J.R.,
            Gelman,R., Brennan,C. and Polyak,K.
  TITLE     Combined cDNA array comparative genomic hybridization and serial
            analysis of gene expression analysis of breast tumor progression
  JOURNAL   Cancer Res 66 (8), 4065-4078 (2006)
   PUBMED   16618726
REFERENCE   9  (bases 1 to 620)
  AUTHORS   de Wit,N.J., Rijntjes,J., Diepstra,J.H., van Kuppevelt,T.H.,
            Weidle,U.H., Ruiter,D.J. and van Muijen,G.N.
  TITLE     Analysis of differential gene expression in human melanocytic
            tumour lesions by custom made oligonucleotide arrays
  JOURNAL   Br J Cancer 92 (12), 2249-2261 (2005)
   PUBMED   15900300
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
  REMARK    GeneRIF: In this paper, the authors identified and cloned the H2AFJ
            gene on chr 12 and used it as a control for studying two macroH2A
            genes.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010168.6.
            
            On Jan 26, 2021 this sequence version replaced NM_177925.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is located on chromosome 12 and encodes a
            replication-independent histone that is a variant H2A histone. The
            protein is divergent at the C-terminus compared to the consensus
            H2A histone family member. This gene also encodes an antimicrobial
            peptide with antibacterial and antifungal activity.[provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BG721557.1, EB387325.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000544848.3/
                                                  ENSP00000438553.1
            Protein has antimicrobial activity :: PMID: 21178486
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            replication-independent histone    :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               AC010168.6         16150-16769         c
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..620
                     /gene="H2AJ"
                     /gene_synonym="H2AFJ"
                     /note="H2A.J histone"
                     /db_xref="GeneID:55766"
                     /db_xref="HGNC:HGNC:14456"
     exon            1..620
                     /gene="H2AJ"
                     /gene_synonym="H2AFJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..456
                     /gene="H2AJ"
                     /gene_synonym="H2AFJ"
                     /note="H2a/j; buforin I; H2A histone family member J"
                     /codon_start=1
                     /product="histone H2A.J"
                     /protein_id="NP_808760.1"
                     /db_xref="CCDS:CCDS31752.1"
                     /db_xref="GeneID:55766"
                     /db_xref="HGNC:HGNC:14456"
                     /translation="MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESQKTKSK"
     regulatory      601..606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2AJ"
                     /gene_synonym="H2AFJ"
                     /note="hexamer: AATAAA"
     polyA_site      620
                     /gene="H2AJ"
                     /gene_synonym="H2AFJ"
                     /note="major polyA site"
ORIGIN      
        1 gcattccggt accggacgcc gagagcggtt tgtctccgtc tctggagttg taggcgagag
       61 gtgatcatgt ccggtcgcgg gaaacagggc ggcaaagtgc gagcaaaggc caaatcccgc
      121 tcctcccgcg cgggcctgca gttcccggtg ggccgagtgc acagactgct gcgcaaaggg
      181 aactacgcgg agcgagtggg cgccggggcg ccggtgtacc tggcggcggt gttggagtac
      241 cttacggcgg agatcctgga gctggctggc aacgccgcgc gtgacaacaa gaagaccagg
      301 ataattcccc gccacctgca gctcgccatc cgcaacgacg aggagttaaa caagctgctg
      361 ggcaaagtga ccatcgctca gggcggcgtc ctgcccaaca tccaggccgt gctgctgccc
      421 aagaagacgg agagtcagaa gacgaagagc aaatgaccct gacgccgccc tcagggagct
      481 ggctccccca gcaaaggccc ttttcatggt cgtcccgcaa tgcttttgaa tgtgctggat
      541 gtcatggagg gccggtgaca tctagcgggg aggtgggcgg cgagggtccc ggcgggagcc
      601 aataaagttg gtgaaaatcg
//
