LOCUS       NM_003512                519 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens H2A clustered histone 6 (H2AC6), mRNA.
ACCESSION   NM_003512
VERSION     NM_003512.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Seal,R.L., Denny,P., Bruford,E.A., Gribkova,A.K., Landsman,D.,
            Marzluff,W.F., McAndrews,M., Panchenko,A.R., Shaytan,A.K. and
            Talbert,P.B.
  TITLE     A standardized nomenclature for mammalian histone genes
  JOURNAL   Epigenetics Chromatin 15 (1), 34 (2022)
   PUBMED   36180920
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 519)
  AUTHORS   Singh,R., Mortazavi,A., Telu,K.H., Nagarajan,P., Lucas,D.M.,
            Thomas-Ahner,J.M., Clinton,S.K., Byrd,J.C., Freitas,M.A. and
            Parthun,M.R.
  TITLE     Increasing the complexity of chromatin: functionally distinct roles
            for replication-dependent histone H2A isoforms in cell
            proliferation and carcinogenesis
  JOURNAL   Nucleic Acids Res 41 (20), 9284-9295 (2013)
   PUBMED   23956221
REFERENCE   4  (bases 1 to 519)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 519)
  AUTHORS   Bergink,S., Salomons,F.A., Hoogstraten,D., Groothuis,T.A., de
            Waard,H., Wu,J., Yuan,L., Citterio,E., Houtsmuller,A.B.,
            Neefjes,J., Hoeijmakers,J.H., Vermeulen,W. and Dantuma,N.P.
  TITLE     DNA damage triggers nucleotide excision repair-dependent
            monoubiquitylation of histone H2A
  JOURNAL   Genes Dev 20 (10), 1343-1352 (2006)
   PUBMED   16702407
REFERENCE   6  (bases 1 to 519)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 519)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol Cell Biol 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   8  (bases 1 to 519)
  AUTHORS   Albig,W. and Doenecke,D.
  TITLE     The human histone gene cluster at the D6S105 locus
  JOURNAL   Hum Genet 101 (3), 284-294 (1997)
   PUBMED   9439656
REFERENCE   9  (bases 1 to 519)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   10 (bases 1 to 519)
  AUTHORS   Albig,W., Kioschis,P., Poustka,A., Meergans,K. and Doenecke,D.
  TITLE     Human histone gene organization: nonregular arrangement within a
            large cluster
  JOURNAL   Genomics 40 (2), 314-322 (1997)
   PUBMED   9119399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91328.1.
            
            On Dec 3, 2019 this sequence version replaced NM_003512.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. This gene is found in
            the large histone gene cluster on chromosome 6. [provided by
            RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DA458476.1, BP330501.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match            :: ENST00000377791.4/
                                             ENSP00000367022.2
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               U91328.1           16369-16887         c
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..519
                     /gene="H2AC6"
                     /gene_synonym="dJ221C16.4; H2A/l; H2AFL; HIST1H2AC"
                     /note="H2A clustered histone 6"
                     /db_xref="GeneID:8334"
                     /db_xref="HGNC:HGNC:4733"
                     /db_xref="MIM:602794"
     exon            1..519
                     /gene="H2AC6"
                     /gene_synonym="dJ221C16.4; H2A/l; H2AFL; HIST1H2AC"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..454
                     /gene="H2AC6"
                     /gene_synonym="dJ221C16.4; H2A/l; H2AFL; HIST1H2AC"
                     /note="histone H2AC; histone cluster 1, H2ac; H2A histone
                     family, member L; histone 1, H2ac; histone H2A/l; histone
                     cluster 1 H2A family member c"
                     /codon_start=1
                     /product="histone H2A type 1-C"
                     /protein_id="NP_003503.1"
                     /db_xref="CCDS:CCDS4585.1"
                     /db_xref="GeneID:8334"
                     /db_xref="HGNC:HGNC:4733"
                     /db_xref="MIM:602794"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 gattttgttt gttttctcgt gagcttaggc cgctggtttt ggtgattttt gtctgattgc
       61 aatgtctgga cgtggtaagc aaggaggcaa agctcgcgcc aaagcgaaat cccgctcttc
      121 tcgcgctggt ctccagttcc cggtgggccg agtgcaccgc ctgctccgta aaggcaacta
      181 cgcagagcgg gttggggcag gcgcgccggt gtacctggcg gcggtgttag agtacctgac
      241 cgccgagatc ctggagctgg ccggcaacgc ggctcgcgac aacaagaaga ctcgcatcat
      301 cccgcgccac ttgcagctgg ccatccgcaa cgacgaggag ctcaacaaac tgctaggccg
      361 ggtgaccatt gctcagggcg gcgtccttcc taacatccag gccgtgcttc tgcctaagaa
      421 gaccgagagt caccacaagg ccaagggcaa gtgatttgac aggtatctga gctcccggaa
      481 acgctatcaa acccaaaggc tcttttcaga gccccccta
//
